New hope for Hard-to-Treat breast cancer: targeted combo trial launches

NCT ID NCT07207070

First seen Nov 01, 2025 · Last updated May 01, 2026 · Updated 22 times

Summary

This study tests whether adding a new drug (JS105) to two standard medications (dalpiciclib and fulvestrant) can help people with a certain genetic form of advanced breast cancer live longer without their disease getting worse. About 312 adults with PIK3CA-mutated, HR-positive, HER2-negative breast cancer that has returned or spread will take part. The goal is to see if the three-drug combination works better than the two-drug standard.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Chinese Acadamy of Medical Sciences and Peking Union Medical College

    RECRUITING

    Beijing, Beijing Municipality, 100021, China

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Henan Provincial Cancer Hospital

    RECRUITING

    Zhengzhou, Henan, 450003, China

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

Conditions

Explore the condition pages connected to this study.