New drug combo aims to boost lung cancer treatment

NCT ID NCT06116786

Recruiting now Disease control Sponsor: Johnson & Johnson Enterprise Innovation Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 07, 2026 · Updated 2 times

Summary

This early-stage trial is testing a new drug called JNJ-86974680, alone or with another drug (cetrelimab) and radiation, in people with advanced non-small cell lung cancer. The main goal is to find a safe and tolerable dose. About 126 participants will be enrolled. The study is currently recruiting.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: JNJ-86974680 (an A2a receptor antagonist) and cetrelimab (an immunotherapy drug)
What this could lead to: If successful, this could help identify a safe dose of a new drug combination that may improve treatment options for advanced lung cancer.
What could go wrong: This is an early Phase 1 trial focused on safety, not effectiveness. The drug may cause side effects or fail to show benefit in later studies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARCINOMA, NON-SMALL-CELL LUNG

Contacts and locations

Locations

Charite Research Organisation GmbH
COMPLETED

Berlin, 12203, Germany
City of Hope 1
RECRUITING

Newnan, Georgia, 30265, United States
Hackensack University Medical Center
RECRUITING

Hackensack, New Jersey, 07601, United States
Herbert Irving Comprehensive Cancer Center Columbia University Medical Center
RECRUITING

New York, New York, 10032, United States
Hosp Univ Vall D Hebron
RECRUITING

Barcelona, 8035, Spain
Hosp. Univ. 12 de Octubre
RECRUITING

Madrid, 28041, Spain
Hosp. Univ. I Politecni La Fe
RECRUITING

Valencia, 46026, Spain
Hosp. Univ. Quiron Dexeus
RECRUITING

Barcelona, 08028, Spain
Next Virginia
RECRUITING

Fairfax, Virginia, 22031, United States
Providence Portland Medical Center
RECRUITING

Portland, Oregon, 97213, United States
Roswell Park Comprehensive Cancer Center
RECRUITING

Buffalo, New York, 14203, United States
Samsung Medical Center
RECRUITING

Seoul, 06351, South Korea
Severance Hospital Yonsei University Health System
RECRUITING

Seoul, 03722, South Korea
Thomas Jefferson University
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
Universitaetsklinikum Giessen und Marburg GmbH
RECRUITING

Giessen, 35392, Germany

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