Experimental drug duo takes on tough lymphoma

NCT ID NCT06660563

Ongoing Disease control Sponsor: Janssen Research & Development, LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 3 times

Summary

This early-phase trial tests two experimental drugs, JNJ-80948543 and JNJ-75348780, given together to people with relapsed or refractory B-cell non-Hodgkin lymphoma. The study involves 19 participants and aims to find the safest dose and check for side effects. It is not yet known if the combination will shrink tumors or improve outcomes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: JNJ-80948543 and JNJ-75348780 (two experimental drugs that help the immune system attack cancer cells)
What this could lead to: If successful, this could point toward a new combination treatment option for people with hard-to-treat B-cell non-Hodgkin lymphoma.
What could go wrong: This is a very early Phase 1 trial with only 19 participants, so it is primarily testing safety and dosing. The drugs may cause serious side effects or not work well enough to move forward.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

diffuse large B-cell lymphoma high grade B-cell lymphoma lymphoma, non-Hodgkin, familial non-Hodgkin lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LYMPHOMA, NON-HODGKIN

Contacts and locations

Locations

China Medical University Hospital

Taichung, 40447, Taiwan
Concord Hospital

Concord, 2139, Australia
Hosp Univ Vall D Hebron

Barcelona, 08035, Spain
Hosp. Clinic de Barcelona

Barcelona, 08036, Spain
Hosp. Gral. Univ. Gregorio Maranon

Madrid, 28007, Spain
Hosp. Univ. 12 de Octubre

Madrid, 28041, Spain
Inst. Cat. Doncologia-H Duran I Reynals

L'Hospitalet de Llobregat, 08908, Spain
Macquarie University Hospital

North Ryde, 2109, Australia
National Taiwan University Hospital

Taipei, 100, Taiwan
St Vincents Hospital Melbourne

Fitzroy, 3065, Australia
University Hospitals Of Leicester Nhs Trust

Leicester, Le1 5ww, United Kingdom

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