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New hope for Hard-to-Treat lung cancer: targeted pill shows promise

NCT ID NCT05445843

Ongoing Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 02, 2026 · Updated 1 time

Summary

This study tests a new drug called JDQ443 in people with advanced lung cancer that has a specific genetic change (KRAS G12C mutation) and does not respond well to standard treatments. The drug is taken as a pill and aims to shrink or control the cancer. About 95 participants will receive JDQ443 alone as their first treatment for advanced disease.

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Conditions

The condition(s) this trial relates to.

lung neoplasm non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOCALLY ADVANCED OR METASTATIC KRAS G12C-MUTATED NSCLC WITH A PD-L1 EXPRESSION <1% OR A PD-L1 EXPRESSION ≥ 1% AND AN STK11 CO-MUTATION

Contacts and locations

Locations

  • Novartis Investigative Site

    Pilar, Buenos Aires, B1629AHJ, Argentina

  • Novartis Investigative Site

    Córdoba, Córdoba Province, X5016KEH, Argentina

  • Novartis Investigative Site

    Buenos Aires, C1426AGE, Argentina

  • Novartis Investigative Site

    Córdoba, X5000JHQ, Argentina

  • Novartis Investigative Site

    Feldkirch, A 6807, Austria

  • Novartis Investigative Site

    Wels, A-4600, Austria

  • Novartis Investigative Site

    Sint-Niklaas, Oost Vlaanderen, 9100, Belgium

  • Novartis Investigative Site

    Roeselare, West-Vlaanderen, 8800, Belgium

  • Novartis Investigative Site

    Salvador, Estado de Bahia, 41825-010, Brazil

  • Novartis Investigative Site

    Belo Horizonte, 30360 680, Brazil

  • Novartis Investigative Site

    Rio de Janeiro, 22271-110, Brazil

  • Novartis Investigative Site

    Wuhan, Hubei, 430030, China

  • Novartis Investigative Site

    Changsha, Hunan, 410013, China

  • Novartis Investigative Site

    Beijing, 100036, China

  • Novartis Investigative Site

    Marseille, Bouches Du Rhone, 13915, France

  • Novartis Investigative Site

    Bron, 69677, France

  • Novartis Investigative Site

    Montpellier, 34070, France

  • Novartis Investigative Site

    Saint-Herblain, 44805, France

  • Novartis Investigative Site

    Strasbourg, 67091, France

  • Novartis Investigative Site

    Kempten (Allgäu), Bavaria, 87439, Germany

  • Novartis Investigative Site

    Halle, Saxony-Anhalt, 06120, Germany

  • Novartis Investigative Site

    Hamburg, 21075, Germany

  • Novartis Investigative Site

    Oldenburg, 26121, Germany

  • Novartis Investigative Site

    Tübingen, 72076, Germany

  • Novartis Investigative Site

    Athens, 11526, Greece

  • Novartis Investigative Site

    Mátraháza, 3200, Hungary

  • Novartis Investigative Site

    Thellakom Kottayam, Kerala, 686016, India

  • Novartis Investigative Site

    Varanasi, Uttar Pradesh, 221005, India

  • Novartis Investigative Site

    Bari, BA, 70124, Italy

  • Novartis Investigative Site

    Rozzano, MI, 20089, Italy

  • Novartis Investigative Site

    Roma, RM, 00128, Italy

  • Novartis Investigative Site

    Orbassano, TO, 10043, Italy

  • Novartis Investigative Site

    George Town, Pulau Pinang, 10450, Malaysia

  • Novartis Investigative Site

    Kuching, Sarawak, 93586, Malaysia

  • Novartis Investigative Site

    Breda, North Brabant, 4818 CK, Netherlands

  • Novartis Investigative Site

    Leeuwarden, Provincie Friesland, 8934 AD, Netherlands

  • Novartis Investigative Site

    Porto, 4100-180, Portugal

  • Novartis Investigative Site

    Barcelona, 08035, Spain

  • Novartis Investigative Site

    Madrid, 28041, Spain

  • Novartis Investigative Site

    Bangkok, 10700, Thailand

  • Novartis Investigative Site

    Istanbul, Bagcilar, 34214, Turkey (Türkiye)

  • Novartis Investigative Site

    Diyarbakır, Sur, 21280, Turkey (Türkiye)

  • Novartis Investigative Site

    Ankara, Yenimahalle, 06500, Turkey (Türkiye)

  • Novartis Investigative Site

    Torquay, TQ2 7AA, United Kingdom

  • The Brown University Oncology Group

    Providence, Rhode Island, 02903, United States

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