Immune cell therapy takes on tough blood cancers

NCT ID NCT03331198

Ongoing Disease control Sponsor: Juno Therapeutics, a Subsidiary of Celgene Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 07, 2026 · Updated 3 times

Summary

This study tests a treatment called JCAR017, a type of CAR T-cell therapy, for people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) that has come back or not responded to other treatments. The therapy uses a patient's own immune cells, which are modified in a lab to better attack cancer cells. The trial will test JCAR017 alone or combined with other drugs (ibrutinib or venetoclax) in about 320 adults to see if it is safe and effective.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: JCAR017 (lisocabtagene maraleucel), a CAR T-cell therapy, sometimes combined with ibrutinib or venetoclax
What this could lead to: If successful, this could offer a new treatment option for people with hard-to-treat CLL or SLL, potentially leading to long-term disease control.
What could go wrong: This is an early-phase trial (Phase 1/2), so the treatment may not work for everyone. CAR T-cell therapy can cause serious side effects like cytokine release syndrome or neurological problems.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

B-cell chronic lymphocytic leukemia chronic lymphocytic leukemia/small lymphocytic lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL LYMPHOMA, SMALL LYMPHOCYTIC

Contacts and locations

Locations

Banner MD Anderson Cancer Center

Gilbert, Arizona, 85234, United States
Barbara Ann Karmanos Cancer Institute

Detroit, Michigan, 48201, United States
Baylor University Medical Center

Dallas, Texas, 75246, United States
Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02215, United States
City of Hope

Duarte, California, 91010, United States
Duke University Medical Center

Durham, North Carolina, 27710, United States
Fred Hutchinson Cancer Research Center

Seattle, Washington, 98109, United States
Georgetown University Medical Center

Washington D.C., District of Columbia, 20007, United States
Hackensack University Medical Center

Hackensack, New Jersey, 07601, United States
Huntsman Cancer Institute

Salt Lake City, Utah, 84112, United States
Local Institution - 0001

Basking Ridge, New Jersey, 07920, United States
Local Institution - 0002

Houston, Texas, 77030, United States
Local Institution - 0003

Chicago, Illinois, 60611, United States
Local Institution - 0005

Boston, Massachusetts, 02114, United States
Local Institution - 0006

Birmingham, Alabama, 35294, United States
Local Institution - 0007

Duarte, California, 91010, United States
Local Institution - 0008

Omaha, Nebraska, 68198, United States
Local Institution - 0010

San Francisco, California, 94143, United States
Local Institution - 0015

Boston, Massachusetts, 02215, United States
Local Institution - 0016

Chicago, Illinois, 60637, United States
Local Institution - 0018

Seattle, Washington, 98109, United States
Local Institution - 0019

Atlanta, Georgia, 30342, United States
Local Institution - 0025

La Jolla, California, 92093, United States
Local Institution - 0026

New York, New York, 10032, United States
Local Institution - 0027

New Orleans, Louisiana, 70112, United States
Local Institution - 0028

Salt Lake City, Utah, 84112, United States
Local Institution - 0029

Pittsburgh, Pennsylvania, 15232, United States
Local Institution - 0030

Durham, North Carolina, 27705, United States
Local Institution - 0031

Columbus, Ohio, 43210, United States
Local Institution - 0032

Philadelphia, Pennsylvania, 19107, United States
Local Institution - 0035

New York, New York, 10021, United States
Local Institution - 0038

Hackensack, New Jersey, 07601-2191, United States
Local Institution - 0043

Gilbert, Arizona, 85234, United States
Local Institution - 0054

Rochester, Minnesota, 55905, United States
Local Institution - 0055

Milwaukee, Wisconsin, 53226, United States
Local Institution - 0059

Los Angeles, California, 90095, United States
Local Institution - 0062

Detroit, Michigan, 48201, United States
Local Institution - 0064

Louisville, Kentucky, 40202, United States
Local Institution - 0077

New Brunswick, New Jersey, 08903, United States
Local Institution - 0078

Cleveland, Ohio, 44106, United States
Local Institution - 0079

Dallas, Texas, 75426, United States
Local Institution - 0080

Jacksonville, Florida, 32224, United States
Local Institution - 0082

Oklahoma City, Oklahoma, 73104, United States
Local Institution - 0083

Dallas, Texas, 75390, United States
Local Institution - 0084

Ann Arbor, Michigan, 48109, United States
Local Institution - 0085

Washington D.C., District of Columbia, 20007, United States
Local Institution - 0087

Richmond, Virginia, 23298, United States
Local Institution - 0088

Philadelphia, Pennsylvania, 19104, United States
Local Institution - 0089

Stony Brook, New York, 11794-8160, United States
Local Institution - 0098

Eugene, Oregon, 97401, United States
Local Institution - 0104

Atlanta, Georgia, 30322, United States
Local Institution - 0105

Indianapolis, Indiana, 46237, United States
Local Institution - 0106

Morristown, New Jersey, 07960, United States
Local Institution - 0107

Wichita, Kansas, 67124, United States
Local Institution - 0109

Detroit, Michigan, 48202, United States
Local Institution - 0111

Denver, Colorado, 80218, United States
Local Institution - 0112

Toronto, Ontario, M5G 2C1, Canada
Local Institution - 0114

Edison, New Jersey, 08820, United States
Local Institution - 0117

Chattanooga, Tennessee, 37403, United States
Local Institution - 0118

Winston-Salem, North Carolina, 27157, United States
Local Institution - 0119

Nashville, Tennessee, 37203, United States
Local Institution - 0120

Charlotte, North Carolina, 28204, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Mayo Clinic

Jacksonville, Florida, 32224, United States
Mayo Clinic

Rochester, Minnesota, 55905, United States
Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Northwestern University

Chicago, Illinois, 60611, United States
Rutgers Cancer Institute of New Jersey

New Brunswick, New Jersey, 08903, United States
The Blood and Marrow Transplant Group of Georgia (BMTGA)

Atlanta, Georgia, 30342, United States
The University of Texas MD Anderson Cancer Center

Houston, Texas, 77030, United States
Thomas Jefferson University

Philadelphia, Pennsylvania, 19107, United States
UC San Diego Moores Cancer Center

La Jolla, California, 92093, United States
UPMC Hillman Cancer Center

Pittsburgh, Pennsylvania, 15232, United States
University Hospitals Seidman Cancer Center (Case Western)

Cleveland, Ohio, 44106-5061, United States
University of Alabama at Birmingham

Birmingham, Alabama, 35294, United States
University of California, Los Angeles

Los Angeles, California, 90095, United States
University of California, San Francisco

San Francisco, California, 94143, United States
University of Chicago Medical Center

Chicago, Illinois, 60637, United States
University of Michigan Comprehensive Cancer Center

Ann Arbor, Michigan, 48109-5362, United States
University of Nebraska Medical Center

Omaha, Nebraska, 68198, United States
University of Oklahoma Health Sciences Center (Stephenson Cancer Center)

Oklahoma City, Oklahoma, 73104, United States
University of Pennsylvania Perelman Center for Advanced Medicine

Philadelphia, Pennsylvania, 19104, United States
University of Texas Southwestern Medical Center

Dallas, Texas, 75390, United States
Weill Cornell Medical College

New York, New York, 10065, United States

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