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One-Shot gene therapy could replace frequent eye injections for wet AMD

NCT ID NCT07482176

Recruiting now Disease control Sponsor: Adverum Biotechnologies, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 study tests a single injection of Ixo-vec gene therapy against standard aflibercept injections in 284 people with wet AMD. The goal is to see if Ixo-vec can maintain or improve vision while reducing the need for repeated eye injections. Participants must be at least 50 years old with active disease in the study eye.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

blindness (disorder) eye disorder wet macular degeneration

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NEOVASCULAR AGE-RELATED MACULAR DEGENERATION (NAMD) WET AMD

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Adverum Clinical Site 100

    RECRUITING

    Beverly Hills, California, 90211, United States

  • Adverum Clinical Site 107

    RECRUITING

    Conroe, Texas, 77384, United States

  • Adverum Clinical Site 109

    RECRUITING

    Bakersfield, California, 93309, United States

  • Adverum Clinical Site 116

    RECRUITING

    Denver, Colorado, 80207, United States

  • Adverum Clinical Site 124

    RECRUITING

    Deerfield Beach, Florida, 33064, United States

  • Adverum Clinical Site 126

    RECRUITING

    Phoenix, Arizona, 85014, United States

  • Adverum Clinical Site 127

    RECRUITING

    Austin, Texas, 78705, United States

  • Adverum Clinical Site 130

    RECRUITING

    Poway, California, 92064, United States

  • Adverum Clinical Site 140

    RECRUITING

    Sacramento, California, 95825, United States

  • Adverum Clinical Site 145

    RECRUITING

    Arlington, Texas, 76012, United States

  • Adverum Clinical Site 162

    RECRUITING

    McAllen, Texas, 78503, United States

  • Adverum Clinical Site 165

    RECRUITING

    Waterford, Connecticut, 06385, United States

  • Adverum Clinical Site 168

    RECRUITING

    Miami Springs, Florida, 33166, United States

  • Adverum Clinical Site 169

    RECRUITING

    Fullerton, California, 92835, United States

  • Adverum Clinical Site 171

    RECRUITING

    Teaneck, New Jersey, 07666, United States

  • Adverum Clinical Site 172

    RECRUITING

    Encino, California, 91436, United States

  • Adverum Clinical Site 175

    RECRUITING

    Santa Barbara, California, 93103, United States

  • Adverum Clinical Site 176

    RECRUITING

    Fort Lauderdale, Florida, 33308, United States

  • Adverum Clinical Site 178

    RECRUITING

    Phoenix, Arizona, 85020, United States

  • Adverum Clinical Site 181

    RECRUITING

    Erie, Pennsylvania, 16505, United States

  • Adverum Clinical Site 182

    RECRUITING

    Augusta, Georgia, 30909, United States

  • Adverum Clinical Site 183

    RECRUITING

    South Miami, Florida, 33143, United States

  • Adverum Clinical Site 184

    RECRUITING

    Deerfield Beach, Florida, 33064, United States

  • Adverum Clinical Site 189

    RECRUITING

    Walnut Creek, California, 94598, United States

  • Adverum Clinical Site 194

    RECRUITING

    Dallas, Texas, 75231, United States

  • Adverum Clinical Site 195

    RECRUITING

    Carmel, Indiana, 46032, United States

  • Adverum Clinical Site 196

    RECRUITING

    Asheville, North Carolina, 28803, United States

  • Adverum Clinical Site 197

    RECRUITING

    Hagerstown, Maryland, 21740, United States

  • Adverum Clinical Site 198

    RECRUITING

    Springdale, Arkansas, 72764, United States

  • Adverum Clinical Site 199

    RECRUITING

    Lynchburg, Virginia, 24502, United States

  • Adverum Clinical Site 200

    RECRUITING

    Denver, Colorado, 800222, United States

  • Adverum Clinical Site 201

    RECRUITING

    Campbell, California, 95008, United States

  • Adverum Clinical Site 202

    RECRUITING

    Torrance, California, 90503, United States

  • Adverum Clinical Site 204

    RECRUITING

    Hagerstown, Maryland, 21740, United States

  • Adverum Clinical Site 205

    RECRUITING

    Carmel, Indiana, 46032, United States

  • Adverum Clinical Site 207

    RECRUITING

    Oak Park, Illinois, 60304, United States

  • Adverum Clinical Site 209

    RECRUITING

    Wake Forest, North Carolina, 27587, United States

  • Adverum Clinical Site 211

    RECRUITING

    Greensboro, North Carolina, 27401, United States

  • Adverum Clinical Site 212

    RECRUITING

    Sacramento, California, 95841, United States

  • Adverum Clinical Site 213

    RECRUITING

    Orlando, Florida, 32806, United States

  • Adverum Clinical Site 214

    RECRUITING

    Lakeland, Florida, 33805, United States

  • Adverum Clinical Site 215

    RECRUITING

    Redlands, California, 92374, United States

  • Adverum Clinical Site 216

    RECRUITING

    Jackson, Mississippi, 39202, United States

  • Adverum Clinical Site 219

    RECRUITING

    Greensboro, North Carolina, 27401, United States

  • Adverum Clinical Site 220

    RECRUITING

    Hickory, North Carolina, 28602, United States

  • Adverum Clinical Site 221

    RECRUITING

    Fort Myers, Florida, 33912, United States

  • Adverum Clinical Site 222

    RECRUITING

    Ladson, South Carolina, 29456, United States

  • Adverum Clinical Site 223

    RECRUITING

    Phoenix, Arizona, 85020, United States

  • Adverum Clinical Site 224

    RECRUITING

    Huntington Beach, California, 92647, United States

  • Adverum Clinical Site 225

    RECRUITING

    Liverpool, New York, 13088, United States

  • Adverum Clinical Site 228

    RECRUITING

    Schertz, Texas, 78154, United States

  • Adverum Clinical Site 229

    RECRUITING

    Scottsdale, Arizona, 85255, United States

  • Adverum Clinical Site 231

    RECRUITING

    The Woodlands, Texas, 77384, United States

  • Adverum Clinical Site 232

    RECRUITING

    San Marcos, Texas, 78666, United States

  • Adverum Clinical Site 236

    RECRUITING

    Gainesville, Florida, 32607, United States

  • Adverum Clinical Site 237

    RECRUITING

    Tyler, Texas, 75703, United States

  • Adverum Clinical Site 238

    RECRUITING

    Winter Haven, Florida, 33880, United States

  • Adverum Clinical Site 239

    RECRUITING

    Philadelphia, Pennsylvania, 19102, United States

  • Adverum Clinical Site 240

    RECRUITING

    Bloomfield, New Jersey, 07003, United States

  • Adverum Clinical Site 241

    RECRUITING

    Bluffton, South Carolina, 29910, United States

  • Adverum Clinical Site 242

    RECRUITING

    Sun City, Arizona, 85351, United States

  • Adverum Clinical Site 243

    RECRUITING

    Austin, Texas, 78750, United States

  • Adverum Clinical Site 248

    RECRUITING

    Beachwood, Ohio, 44122-5846, United States

  • Adverum Clinical Site 249

    RECRUITING

    Silverdale, Washington, 98383, United States

  • Adverum Clinical Site 252

    RECRUITING

    Portland, Oregon, 97225, United States