One-Shot gene therapy could replace frequent eye injections for wet AMD

NCT ID NCT07482176

Recruiting now Disease control Sponsor: Adverum Biotechnologies, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 16, 2026 · Updated 2 times

Summary

This phase 3 study tests a single injection of Ixo-vec gene therapy against standard aflibercept injections in 284 people with wet AMD. The goal is to see if Ixo-vec can maintain or improve vision while reducing the need for repeated eye injections. Participants must be at least 50 years old with active disease in the study eye.

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Conditions

The condition(s) this trial relates to.

blindness (disorder) eye disorder wet macular degeneration

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NEOVASCULAR AGE-RELATED MACULAR DEGENERATION (NAMD) WET AMD

Contacts and locations

Locations

Adverum Clinical Site 100
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Beverly Hills, California, 90211, United States
Adverum Clinical Site 101
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Nashville, Tennessee, 37203, United States
Adverum Clinical Site 107
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Conroe, Texas, 77384, United States
Adverum Clinical Site 109
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Bakersfield, California, 93309, United States
Adverum Clinical Site 110
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Philadelphia, Pennsylvania, 19107, United States
Adverum Clinical Site 116
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Denver, Colorado, 80207, United States
Adverum Clinical Site 120
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St. Petersburg, Florida, 33711, United States
Adverum Clinical Site 124
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Deerfield Beach, Florida, 33064, United States
Adverum Clinical Site 126
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Phoenix, Arizona, 85014, United States
Adverum Clinical Site 127
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Austin, Texas, 78705, United States
Adverum Clinical Site 130
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Poway, California, 92064, United States
Adverum Clinical Site 140
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Sacramento, California, 95825, United States
Adverum Clinical Site 145
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Arlington, Texas, 76012, United States
Adverum Clinical Site 148
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Tampa, Florida, 33609, United States
Adverum Clinical Site 162
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McAllen, Texas, 78503, United States
Adverum Clinical Site 165
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Waterford, Connecticut, 06385, United States
Adverum Clinical Site 168
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Miami Springs, Florida, 33166, United States
Adverum Clinical Site 169
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Fullerton, California, 92835, United States
Adverum Clinical Site 171
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Teaneck, New Jersey, 07666, United States
Adverum Clinical Site 172
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Encino, California, 91436, United States
Adverum Clinical Site 175
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Santa Barbara, California, 93103, United States
Adverum Clinical Site 176
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Fort Lauderdale, Florida, 33308, United States
Adverum Clinical Site 178
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Phoenix, Arizona, 85020, United States
Adverum Clinical Site 179
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Oak Forest, Illinois, 60452, United States
Adverum Clinical Site 181
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Erie, Pennsylvania, 16505, United States
Adverum Clinical Site 182
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Augusta, Georgia, 30909, United States
Adverum Clinical Site 183
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South Miami, Florida, 33143, United States
Adverum Clinical Site 184
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Deerfield Beach, Florida, 33064, United States
Adverum Clinical Site 185
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San Antonio, Texas, 78240, United States
Adverum Clinical Site 189
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Walnut Creek, California, 94598, United States
Adverum Clinical Site 194
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Dallas, Texas, 75231, United States
Adverum Clinical Site 195
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Carmel, Indiana, 46032, United States
Adverum Clinical Site 196
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Asheville, North Carolina, 28803, United States
Adverum Clinical Site 197
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Hagerstown, Maryland, 21740, United States
Adverum Clinical Site 198
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Springdale, Arkansas, 72764, United States
Adverum Clinical Site 199
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Lynchburg, Virginia, 24502, United States
Adverum Clinical Site 200
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Denver, Colorado, 800222, United States
Adverum Clinical Site 201
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Campbell, California, 95008, United States
Adverum Clinical Site 202
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Torrance, California, 90503, United States
Adverum Clinical Site 204
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Hagerstown, Maryland, 21740, United States
Adverum Clinical Site 205
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Carmel, Indiana, 46032, United States
Adverum Clinical Site 206
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Plantation, Florida, 33324, United States
Adverum Clinical Site 207
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Oak Park, Illinois, 60304, United States
Adverum Clinical Site 209
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Wake Forest, North Carolina, 27587, United States
Adverum Clinical Site 211
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Greensboro, North Carolina, 27401, United States
Adverum Clinical Site 212
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Sacramento, California, 95841, United States
Adverum Clinical Site 213
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Orlando, Florida, 32806, United States
Adverum Clinical Site 214
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Lakeland, Florida, 33805, United States
Adverum Clinical Site 215
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Redlands, California, 92374, United States
Adverum Clinical Site 216
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Jackson, Mississippi, 39202, United States
Adverum Clinical Site 219
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Greensboro, North Carolina, 27401, United States
Adverum Clinical Site 220
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Hickory, North Carolina, 28602, United States
Adverum Clinical Site 221
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Fort Myers, Florida, 33912, United States
Adverum Clinical Site 222
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Ladson, South Carolina, 29456, United States
Adverum Clinical Site 223
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Phoenix, Arizona, 85020, United States
Adverum Clinical Site 224
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Huntington Beach, California, 92647, United States
Adverum Clinical Site 225
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Liverpool, New York, 13088, United States
Adverum Clinical Site 228
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Schertz, Texas, 78154, United States
Adverum Clinical Site 229
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Scottsdale, Arizona, 85255, United States
Adverum Clinical Site 231
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The Woodlands, Texas, 77384, United States
Adverum Clinical Site 232
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San Marcos, Texas, 78666, United States
Adverum Clinical Site 234
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Cary, North Carolina, 27511, United States
Adverum Clinical Site 236
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Gainesville, Florida, 32607, United States
Adverum Clinical Site 237
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Tyler, Texas, 75703, United States
Adverum Clinical Site 238
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Winter Haven, Florida, 33880, United States
Adverum Clinical Site 239
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Philadelphia, Pennsylvania, 19102, United States
Adverum Clinical Site 240
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Bloomfield, New Jersey, 07003, United States
Adverum Clinical Site 241
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Bluffton, South Carolina, 29910, United States
Adverum Clinical Site 242
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Sun City, Arizona, 85351, United States
Adverum Clinical Site 243
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Austin, Texas, 78750, United States
Adverum Clinical Site 244
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Rochester, New York, 14620, United States
Adverum Clinical Site 245
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Mesa, Arizona, 85206, United States
Adverum Clinical Site 246
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Chicago, Illinois, 60616, United States
Adverum Clinical Site 247
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Cleveland, Ohio, 44130, United States
Adverum Clinical Site 248
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Beachwood, Ohio, 44122-5846, United States
Adverum Clinical Site 249
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Silverdale, Washington, 98383, United States
Adverum Clinical Site 252
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Portland, Oregon, 97225, United States
Adverum Clinical Site 253
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Carmel, Indiana, 46032, United States
Adverum Clinical Site 254
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Edmond, Oklahoma, 73013, United States

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