New hope for rare bile duct cancer: targeted pill shows promise in Late-Stage trial
NCT ID NCT05876754
First seen Jun 26, 2026 · Last updated Jul 31, 2026 · Updated 2 times
Summary
This study tests a daily pill called ivosidenib in 220 adults with advanced bile duct cancer that has a specific IDH1 gene mutation and has not responded to prior treatment. The goal is to confirm the drug's safety and effectiveness. Participants take the tablet once daily in 28-day cycles as long as they benefit and tolerate it.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Ivosidenib (oral tablet)
- What this could lead to
- If successful, this could provide a treatment option for people with a specific genetic form of advanced bile duct cancer that has not responded to other therapies.
- What could go wrong
- This is an early-access study, not a final approval trial. Side effects like heart rhythm changes or other adverse events may occur, and the drug may not work for everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for CHOLANGIOCARCINOMA are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
A.O.U. Città della Salute e della Scienza di Torino
Turin, Italy
-
AOU Careggi
Florence, Italy
-
AOUI Verona - Ospedale Borgo Roma
Verona, Italy
-
Amsterdam UMC, location AMC
Amsterdam, Netherlands
-
Asan Medical Center
Seoul, South Korea
-
CHA Bundang Medical Center
Seongnam, South Korea
-
CHU Bordeaux, Hôpital Haut-Lévêque
Pessac, France
-
CHU Montpellier
Montpellier, France
-
CHU de Poitiers
Poitiers, France
-
Centre Hospitalier Universitaire de Nantes CHU de Nantes
Nantes, France
-
Centrul de Oncologie Sfantu Necta
Craiova, Romania
-
Charite Universittsmedizin Berlin
Berlin, Germany
-
Cliniques Univ St Luc - Gastro-Enterology
Woluwe-Saint-Lambert, Belgium
-
Complejo Hospitalario Universitario A Coruña (CHUAC)
A Coruña, Spain
-
Cork University Hospital
Cork, Ireland
-
Erebouni MC
Yerevan, Armenia
-
Fondazione IRCCS Istituto Nazionale dei Tumori
Milan, Italy
-
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Roma, Italy
-
Hokkaido University Hospital
Sapporo, Japan
-
Hopital de la Timone
Marseille, France
-
Hospital General Universitario Gregorio Maranon
Madrid, Spain
-
Hospital General de Elche
Elche, Spain
-
Hospital Universitari Vall d'Hebron/Vall Hebron Institute of Oncology (VHIO)
Barcelona, Spain
-
Hospital Universitario 12 de octubre
Madrid, Spain
-
Hospital Universitario Fundacion Jimenez Diaz
Madrid, Spain
-
Hospital Universitario HM Sanchinarro
Madrid, Spain
-
Hospital Universitario Marqués de Valdecilla
Santander, Spain
-
Hospital Universitario Reina Sofa
Córdoba, Spain
-
Hospital Universitario de Navarra
Pamplona, Spain
-
Humanitas Research Hospital
Rozzano, Italy
-
Hôpital Privé Jean Mermoz
Lyon, France
-
IRCCS Arcispedale Santa Maria Nuova
Reggio Emilia, Italy
-
Imperial College London
London, United Kingdom
-
Institute Mutualiste Montsouris
Paris, France
-
Institutul Clinic Fundeni
Bucharest, Romania
-
Istituto Nazionale Tumori IRCCS Fondazione Pascale
Naples, Italy
-
Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Ospedale Casa Sollievo della Sofferenza (CSS)
San Giovanni Rotondo, Italy
-
Kanagawa Cancer Center
Kanagawa, Japan
-
Karolinska University Hospital
Stockholm, Sweden
-
Kinghorn Cancer Centre
Sydney, Australia
-
Klinik für Gastroenterologie, Hepatologie und Infektiologie Universitätsklinikum Düsseldorf
Düsseldorf, 40225, Germany
-
Klinikum der Universitaet Muenchen-Grosshadern
München, Germany
-
Kumamoto University hospital
Kumamoto, Japan
-
London Regional Cancer Program
London, Canada
-
Medizinische Fakultaet der Universitaet Freiburg
Freiburg im Breisgau, Germany
-
Medizinische Hochschule Hannover
Hanover, Germany
-
Medizinische Universitaet Graz
Graz, Austria
-
Medizinische Universitaet Wien Universitaetsklinik fuer Innere Medizin I
Vienna, Austria
-
Municipal Hospital Ploiesti
Ploieşti, Romania
-
NSHA, QEII Health Sciences Centre
Halifax, Canada
-
National Cancer Center Hospital
Tokyo, Japan
-
National Center of Oncology of Ra M
Yerevan, Armenia
-
Ordensklinikum Linz GmbH
Linz, Austria
-
Osaka International Cancer Institution
Osaka, Japan
-
Ospedale San Raffaele
Milan, Italy
-
Policlinico S. Orsola-Malpighi
Bologna, Italy
-
Princess Margaret Cancer Center
Toronto, Canada
-
Radiotherapy Center Cluj
Otopeni, Romania
-
Regional Institute of Gastroenterology and Hepatology
Cluj-Napoca, Romania
-
Royal brisbane & Women's Hospital
Brisbane, Australia
-
Sahlgrenska University Hospital
Gothenburg, Sweden
-
Samsung Medical Center
Seoul, South Korea
-
Seoul National University
Seoul, South Korea
-
Shikoku Cancer Center
Matsuyama, Japan
-
St John of God Hospital - Bendat Family Comprehensive Cancer Centre (BFCCC)
Subiaco, Australia
-
St Vincent's Hospital
Fitzroy, Australia
-
St. James Hospital
Dublin, Ireland
-
St. Vincent's Private Hospital
Dublin, Ireland
-
Sunnybrook Health Sciences Centre
Toronto, Canada
-
The Beatson Institute West of Scotland Cancer Research
Glasgow, United Kingdom
-
The Christie NHS Foundation Trust
Manchester, United Kingdom
-
The Newcastle Upon Tyne Hospitals
Newcastle upon Tyne, United Kingdom
-
The Queen Elizabeth Hospital
Woodville, Australia
-
Tom Baker Cancer Center
Calgary, Canada
-
UZ Leuven
Leuven, Belgium
-
Universitaetsklinik fuer Innere Medizin III, mit Hämatologie, internistischer Onkologie, Hämostaseologie, Infektiologie, Rheumatologie und Onkologisches Zentrum
Salzburg, Austria
-
Universitaetsklinikum Carl-Gustav-Carus
Dresden, Germany
-
Universitaetsklinikum Frankfurt
Frankfurt, Germany
-
Universitair Ziekenhuis Gent UZ Gent
Ghent, Belgium
-
Universite Libre de Bruxelles ULB -
Brussels, Belgium
-
Universiteit Maastricht UM - Maastricht University Medical Centre MUMC
Limburg, Netherlands
-
University College London Hospital NHS Trust
London, United Kingdom
-
University Hospitals Birmingham (UHB) NHS Foundation Trust - Queen Elizabeth Hospital Birmingham (QEHB)
Birmingham, United Kingdom
-
Yonsei University Health System
Seoul, South Korea
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- A new test could reveal how radiation affects the liver
- Can blood tests reveal how liver and bile duct cancers respond to treatment?
- Can a smart drug home in on Hard-to-Treat GI cancers?
- Can matching drugs to tumor genes beat biliary cancer?
- Can a new drug ST316 shrink Hard-to-Treat tumors?
- Web tool aims to empower rare cancer patients in genomic choices