New drug combo aims to boost immune attack on tough lung cancer

NCT ID NCT07057791

Recruiting now Disease control Sponsor: PrECOG, LLC. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 6 times

Summary

This study tests a new drug called ivonescimab, given with standard chemotherapy, for people with extensive-stage small cell lung cancer who haven't had treatment yet. Ivonescimab is a special antibody that helps the immune system fight cancer and may also block blood vessels that feed tumors. The goal is to find the best dose of ivonescimab and see how well it works and what side effects occur. About 60 adults will take part.

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Conditions

The condition(s) this trial relates to.

small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EXTENSIVE STAGE LUNG SMALL CELL CANCER

Contacts and locations

Locations

Aspirus Cancer Center Wausau
RECRUITING

Wausau, Wisconsin, 54401, United States
Fox Chase Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19111, United States
Gundersen
RECRUITING

La Crosse, Wisconsin, 54601, United States
Guthrie
RECRUITING

Sayre, Pennsylvania, 18840, United States
Montefiore Medical Center- Montefiore Medical Park
RECRUITING

The Bronx, New York, 10461, United States
Morristown Medical Center
RECRUITING

Morristown, New Jersey, 07960, United States
Ohio State Univerity
RECRUITING

Columbus, Ohio, 43210, United States
Rutgers Cancer Institute
RECRUITING

New Brunswick, New Jersey, 08901, United States
UPMC Hillman Cancer Center
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
University of Maryland
RECRUITING

Baltimore, Maryland, 21201, United States
University of Miami
RECRUITING

Miami, Florida, 33136, United States
Universtiy of Virginia
RECRUITING

Charlottesville, Virginia, 22908, United States

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