Early trial for Kids' transplant complication halted after only 2 participants

NCT ID NCT03721965

Terminated Disease control Sponsor: Incyte Corporation Source: ClinicalTrials.gov ↗

Summary

This study aimed to test the safety and effectiveness of a new drug, itacitinib, when given with standard steroids to children who developed a serious complication called acute graft-versus-host disease after a stem cell transplant. The trial was designed for children and teens who had not yet received steroids for this condition. It was terminated early after enrolling only 2 participants, so no conclusions about the treatment's benefit could be made.

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Contacts and locations

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Locations

AOU Citta della Salute e della Scienza di Torino - Ospedale Regina Margherita

Torino, 10126, Italy
Azienda Ospedaliero Unversitatia Policlinico - Vittorio Emanuele - Presido Ospedaliero G. Rodolico

Catania, 95123, Italy
Birmingham Childrens Hospital

Birmingham, B4 6NH, United Kingdom
Bristol Royal Hospital for Children

Bristol, BS2 8BJ, United Kingdom
CHRU Nancy

Vandœuvre-lès-Nancy, 54500, France
CHU Nancy

Vandœuvre-lès-Nancy, 54500, France
CHU de Grenoble

Grenoble, 38043, France
CHU de Grenoble

Grenoble, 38403, France
Central Manchester University Hospital - Royal Manchester Children's Hospital

Manchester, M13 9WL, United Kingdom
Centre Hospitalier Universitaire de Rennes

Rennes, Cedex 2, 35203, France
Children's Hospital Colorado - Center for Cancer and Blood Disorders

Aurora, Colorado, 80045, United States
Children's Hospital of Philadelphia - Center for Childhood Cancer Research

Philadelphia, Pennsylvania, 19104, United States
Childrens Hospital of Orange County

Orange, California, 92868, United States
City of Hope National Medical Center

Duarte, California, 91010, United States
Doernbecher Children's Hospital - Division of Pediatric Hematology

Portland, Oregon, 97239, United States
Duke University Medical Center

Durham, North Carolina, 27710, United States
Fondazione MBBM

Monza, 20900, Italy
Fred Hutchinson Cancer Research Center

Seattle, Washington, 98109-1024, United States
Great Ormond Street Hospital for Children

London, WC1N 3JH, United Kingdom
Hopitaux Universitaires De Strasbourg

Strasbourg, Cedex, 67098, France
Hopitaux Universitaires De Strasbourg

Strasbourg, 67098, France
Hospital Clinico de Santiago de Compostela

Santiago de Compostela, 15706, Spain
Hospital Universitari i Politecnic La Fe

Valencia, 46026, Spain
Hospital Vall D Hebron

Barcelona, 08035, Spain
Leeds Teaching Hospitals NHS Trust

Leeds, LS13EX, United Kingdom
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Nemours/A.I. duPont Hospital for Children

Wilmington, Delaware, 19803, United States
Nicklaus Children's Hospital

Miami, Florida, 33155, United States
Ospedale Pediatrico Bambino Gesu

Roma, 00165, Italy
Policlinico S. Orsola-Malpighi

Bologna, 40138, Italy
Robert Debre Hospital

Paris, 75019, France
Royal Marsden Hospital - Surrey

Surrey Quays, SM2 5PT, United Kingdom
Sarah Cannon Research Institute, LLC

Nashville, Tennessee, 37203, United States
Universitaetsklinikum Aachen, AoeR

Aachen, 52074, Germany
Universitatsklinikum Jena, Klinik fur Kinder und Jugendmedizin

Jena, 07747, Germany
University Hospitals Cleveland Medical Center - Rainbow Babies and Children's Hospital

Cleveland, Ohio, 44106, United States
University of Minnesota Medical Center

Minneapolis, Minnesota, 55454, United States
Vanderbilt University Medical Center

Nashville, Tennessee, 37232-6868, United States

Conditions

Explore the condition pages connected to this study.

ACUTE GRAFT VERSUS HOST DISEASE