New drug combo tested to control dangerous transplant complication

NCT ID NCT03584516

Terminated Disease control Sponsor: Incyte Corporation Source: ClinicalTrials.gov ↗

Summary

This study tested whether adding the experimental drug itacitinib to standard steroid treatment could better control chronic graft-versus-host disease (cGVHD) in people who had stem cell transplants. Researchers enrolled 155 participants with moderate to severe cGVHD who hadn't received much previous treatment. The trial was terminated early, so full results about effectiveness aren't available.

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Contacts and locations

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Locations

A.O.U. Di Modena - Policlinico

Modena, 41124, Italy
A.O.U. Federico Ii

Naples, 80131, Italy
AZ DELTA

Roeselare, 08800, Belgium
Advocate Lutheran General Hospital - Oncology Specislists Sc

Park Ridge, Illinois, 60028, United States
Augusta University - Medical College of Georgia

Augusta, Georgia, 30912, United States
Avera Cancer Institute

Sioux Falls, South Dakota, 57105-2108, United States
Azienda Ospedaliera Bianchi-Melacrino-Morelli Ospedali Riuniti

Reggio Calabria, 89133, Italy
Azienda Ospedaliera Ospedali Riuniti "Villa Sofia - Cervello"

Palermo, 90100, Italy
Azienda Ospedaliera Papa Giovanni Xxiii

Bergamo, 24127, Italy
Azienda Ospedaliero Universitaria Citta Della Salute E Della Scienza

Torino, 10126, Italy
Azienda Ospedaliero-Universitaria Santa Maria Della Misericordia

Udine, 33100, Italy
Azienda Policlinico Vittorio Emanuele

Catania, 95123, Italy
Azienda Socio Sanitaria Territoriale Degli Spedali Civili Di Brescia

Brescia, 25123, Italy
Barts Health Nhs Trust - St Bartholomews Hospital

London, EC1A 7BE, United Kingdom
Bristol Haematology & Oncology Centre

Bristol, BS2 8ED, United Kingdom
CENTRE HOSPITALIER UNIVERSITAIRE DE LIï¿½GE - SART TILMAN

Liège, 04000, Belgium
CLINICA DI EMATOLOGIA, UNIVERSITï¿½ POLITECNICA DELLE MARCHE

Ancona, 60126, Italy
Centre Henri Becquerel

Rouen, 76038, France
Centre Hospitalier D'Angers

Angers, 49000, France
Centre Hospitalier Universitaire de Nantes (Chu de Nantes) - Hotel-Dieu

Nantes, 44000, France
Centro Ricerche Cliniche Di Verona (Crc)

Verona, 37134, Italy
Charite Berlin

Berlin, 12200, Germany
Chru Hopitaux de Tours Hospital Bretonneau

Tours, 37000, France
Chu Amiens Picardie - Hopital Sud

Amiens, 80054, France
Chu de Grenoble - Hopital Albert Michallon

Grenoble, 38700, France
Chu de Nice - Hospital L Archet

Nice, 06800, France
Chu de Rennes - Hospital Pontchaillou

Rennes, 35033, France
City of Hope National Medical Center

Duarte, California, 91010, United States
Clinica Universidad de Navarra (Cun)

Pamplona, 31008, Spain
Comitato Di Bioetica Della Fondazione Irccs Policlinico San Matteo

Pavia, 27100, Italy
Duke University Medical Center

Durham, North Carolina, 27710, United States
Fondazione Irccs Ca Granda Ospedale Maggiore

Milan, 20122, Italy
Fred Hutchinson Cancer Research Center

Seattle, Washington, 98109, United States
General Hospital of Thessaloniki G. Papanikolaou

Thessaloniki, 57010, Greece
Hackensack University Medical Center

Hackensack, New Jersey, 07601-8550, United States
Hadassah Hebrew University Medical Center Ein Karem Hadassah

Jerusalem, 91120, Israel
Henry Ford Health System

Detroit, Michigan, 48202, United States
Hopitaux de Brabois

Vandœuvre-lès-Nancy, 54511, France
Hospital Clinico Universitario de Salamanca

Salamanca, 37007, Spain
Hospital Clinico Universitario de Valencia

Valencia, 46010, Spain
Hospital Clinico de Santiago de Compostela

Santiago de Compostela, 15706, Spain
Hospital General Universitario Gregorio Maranon

Madrid, 28007, Spain
Hospital Maisonneuve Rosemont

Montreal, Quebec, H1T 2M4, Canada
Hospital Regional Universitario de Malaga

Málaga, 29010, Spain
Hospital Universitario Marques de Valdecilla

Santander, 39008, Spain
Hospital Universitario Ramon Y Cajal

Madrid, 28034, Spain
Hospital Universitario Virgen de Las Nieves

Granada, 18014, Spain
Hospital Universitario Y Politcnico de La Fe

Valencia, 46009, Spain
Hospital de La Santa Creu I Sant Pau

Barcelona, 08041, Spain
I.R.C.C.S. Casa Sollievo Della Sofferenza

San Giovanni Rotondo, 71013, Italy
Ico Institut Catala D Oncologia

L'Hospitalet de Llobregat, 08908, Spain
Iii Medizinische Klinik Und Poliklinik Klinikum Rechts Der Isar Technische Universitat Munchen

Munich, 81675, Germany
Illinois Cancer Specialists

Chicago, Illinois, 60714, United States
Imperial College Healthcare Nhs Trust - Hammersmith Hospital

London, W12 0HS, United Kingdom
Indiana University Melvin and Bren Simon Cancer Center

Indianapolis, Indiana, 46202-5201, United States
Institut Catala D Oncologia

Badalona, 08916, Spain
Institut Jules Bordet

Brussels, 01000, Belgium
Institut Paoli-Calmettes

Marseille, 13273, France
Irrcs Instituto Clinico Humanitas

Rozzano, 20089, Italy
Istituto Di Ricovero E Cura A Carattere Scientifico (Irccs) Ospedale San Raffaele

Milan, 20132, Italy
Jefferson University Hospitals

Philadelphia, Pennsylvania, 19107, United States
Karolinska University Hospital Huddinge

Huddinge, 141 86, Sweden
King'S College Hospital (Nhs Foundation)

London, SE5 9RS, United Kingdom
L AZIENDA OSPEDALIERO-UNIVERSITARIA DI BOLOGNA POLICLINICO S. ORSOLA ï¿½ MALPIGHI

Bologna, 40138, Italy
Loyola University Medical Center

Maywood, Illinois, 60153-3328, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Mtz Clinical Research Sp. Zo.O.

Warsaw, 02-106, Poland
Narodowy Instytut Onkologii Im. Marii Sklodowskiej-Curie Panstwowy Instytut Badawczy Oddzial W Gliwi

Gliwice, 44-101, Poland
Nottingham University Hospitals Nhs Trust

Nottingham, NG5 1PB, United Kingdom
Oncology Hematology Care, Inc

Cincinnati, Ohio, 45236, United States
Ordensklinikum Linz Gmbh Elisabethinen

Linz, 04020, Austria
Policlinico Universitario Agostino Gemelli Universita Cattolica Del Sacro Cuore

Roma, 00168, Italy
Rabin Medical Center - Beilinson Hospital

Petach Tiqwa, 49100, Israel
Rambam Medical Center

Haifa, 3109601, Israel
Rush University Medical Center

Chicago, Illinois, 60612, United States
Saint Louis University Cancer Center

St Louis, Missouri, 63110, United States
Saskatchewan Cancer

Saskatoon, Saskatchewan, S7N 4H4, Canada
Selbststandige Abteilung Fur Hamatologie Und Internistische Onkologie

Leipzig, 00341, Germany
Skane University Hospital Lund

Lund, 22185, Sweden
Son Espases University Hospital

Palma, 07120, Spain
Spectrum Health

Grand Rapids, Michigan, 49503, United States
St David'S South Austin Medical Center

Austin, Texas, 78704, United States
St. George'S University Hospitals Nhs Foundation Trust

Tooting, SW17 0QT, United Kingdom
Stony Brook University Medical Center

Stony Brook, New York, 11794, United States
Szpital Kliniczny Przemienienia Panskiego

Poznan, 60-569, Poland
Tel Aviv Sourasky Medical Center

Tel Aviv, 64239, Israel
Texas Oncology - Baylor Sammons Cancer Center

Dallas, Texas, 75246, United States
Texas Oncology - Medical City Dallas

Dallas, Texas, 75230, United States
The Finsen Centre National Hospital

Copenhagen, 02100, Denmark
The Royal Marsden Nhs Foundation Trust - Sutton

Sutton, SM2 5PT, United Kingdom
Tri Star Bone Marrow Transplant

Nashville, Tennessee, 37203, United States
Tufts Medical Center

Boston, Massachusetts, 02111-1552, United States
Tulane University

New Orleans, Louisiana, 70112-2618, United States
Turku University Hospital

Turku, 20521, Finland
UNIVERSITï¿½TSKLINIKUM HALLE (SAALE)

Halle, D06120, Germany
Universita Degli Studi Di Roma La Sapienza - Umberto I Policlinico Di Roma - Centro Di Ematologia

Roma, 00161, Italy
Universitaetsklinikum Erlangen - Medizinische Klinik 5

Erlangen, 91054, Germany
Universitaetsklinikum Jena

Jena, 07740, Germany
Universitaetsklinikum in Tubingen

Tübingen, 72076, Germany
Universitaetsmedizin Rostock

Rostock, 18057, Germany
Universitair Ziekenhuis Antwerpen (Uza)

Edegem, 02650, Belgium
Universitair Ziekenhuis Gent

Ghent, 09000, Belgium
Universitaire Ziekenhuis Leuven - Gasthuisberg

Leuven, 03000, Belgium
Universitatsklinikum Bonn Aoer

Bonn, 00011, Germany
Universitatsklinikum Essen

Essen, 45147, Germany
Universitatsklinikum Koln

Cologne, 50937, Germany
Universitatsklinikum Munster

Münster, 48149, Germany
Universitatsmedizin Der Johannes Gutenberg-Universitat Mainz Iii

Mainz, 55131, Germany
Universitatsspital Zurich

Zurich, 08091, Switzerland
University Clinic Carl Gustav Carus Technical University Dresden

Dresden, 01307, Germany
University Health Network

Toronto, Ontario, M5G 2M9, Canada
University Hospital Mannheim

Mannheim, 68167, Germany
University Hospital of Wales

Cardiff, CF14 4XW, United Kingdom
University Hospital of West Attica - Attikon

Chaïdári, 124 62, Greece
University Hospitals Cleveland Medical Center

Cleveland, Ohio, 44106-1716, United States
University Medical Centre Hamburg-Eppendorf Centre of Oncology

Hamburg, 20246, Germany
University of Alberta

Edmonton, Alberta, T6G 2P4, Canada
University of Arizona Cancer Center - Out Pt.

Tucson, Arizona, 85724, United States
University of Arkansas For Medical Sciences - Winthrop P Rockefeller Cancer Institute

Little Rock, Arkansas, 72205, United States
University of California San Diego Medical Center, Moores Cancer Center

La Jolla, California, 92093, United States
University of Kansas Hospital Authority

Westwood, Kansas, 66160, United States
University of Maryland - Greenebaum Cancer Center

Baltimore, Maryland, 21201, United States
University of Miami Sylvester Comprehensive Cancer Center

Miami, Florida, 33136-1002, United States
University of Michigan

Ann Arbor, Michigan, 48109, United States
University of Minnesota, Masonic Cancer Center

Minneapolis, Minnesota, 55455, United States
University of Pennsylvania Abramson Cancer Center

Philadelphia, Pennsylvania, 19104, United States
University of Pittsburgh

Pittsburgh, Pennsylvania, 15232-1309, United States
University of Rochester, James P. Wilmot Cancer Center

Rochester, New York, 14642-0001, United States
Uniwersyteckie Centrum Kliniczne

Gdansk, 80-592, Poland
Vanderbilt-Ingram Cancer Center

Nashville, Tennessee, 37232, United States
Western Pennsylvania Hospital

Pittsburgh, Pennsylvania, 15224, United States
Winship Cancer Institute of Emory University

Atlanta, Georgia, 30322, United States
Zna Stuivenberg

Antwerp, 02060, Belgium

Conditions

Explore the condition pages connected to this study.

CHRONIC GRAFT VERSUS HOST DISEASE