Four-Drug cocktail aims to crush myeloma before transplant

NCT ID NCT04483739

Ongoing Disease control Sponsor: European Myeloma Network B.V. Source: ClinicalTrials.gov ↗

First seen Jul 16, 2026 · Last updated Jul 17, 2026 · Updated 1 time

Summary

This phase 3 trial tests whether adding the targeted antibody isatuximab to a standard three-drug regimen (carfilzomib, lenalidomide, dexamethasone) can achieve deeper remissions in people newly diagnosed with multiple myeloma who are eligible for a stem cell transplant. Participants receive either the four-drug combo (Isa-KRd) or the standard three-drug combo (KRd) before and after transplant. The main goal is to see if more patients become minimal residual disease (MRD) negative — meaning no cancer cells are detectable by a sensitive test — after consolidation therapy.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: a combination of isatuximab, carfilzomib, lenalidomide, and dexamethasone (Isa-KRd)
What this could lead to: If successful, this could establish a more effective upfront treatment for multiple myeloma, potentially leading to deeper remissions and longer disease control before and after stem cell transplant.
What could go wrong: This is a phase 3 trial, so results are not yet known. Adding a fourth drug may increase side effects, and the benefit in long-term outcomes like survival is still unproven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

plasma cell myeloma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTIPLE MYELOMA

Contacts and locations

Show contact details

Locations

A.O.U. Città della Salute e della Scienza di Torino-U.O. Ematologia

Torino, Italy
Albert Schweitzerplaats 25

Dordrecht, Netherlands
Alexandra Hospital - Department of Clinical Therapeutics National & Kapodistrian University of Athens School of Medicine

Athens, Greece
Amphia Hospital-Internal Medicine - Hematology

Breda, Netherlands
Amsterdam-Vrije Universiteit Medical Center (VUMC)

Amsterdam, Netherlands
Azienda Ospedaliera Santa Croce E Carle - S.C. Ematologia

Cuneo, Italy
Azienda Ospedaliero Universitaria Ospedali Riuniti Umberto I G M Lancisi G Salesi-SOD Clinica Ematologica

Ancona, Italy
Azienda Ospedaliero-Universitaria Di Bologna IRCCS Istituto Di Ricerca E Di Cura A Carattere Scientifico - U.O. di Ematologia

Bologna, Italy
Azienda Ospedaliero-Universitaria Maggiore Della Carita - SDCU Ematologia

Novara, Italy
Azienda Sanitaria Locale Di Pescara - U.O. Ematologia

Pescara, Italy
Azienda Sanitaria Universitaria Giuliano Isontina-SC U.O.C Ematologia

Trieste, Italy
Azienda Socio Sanitaria Territoriale Degli Spedali Civili Di Brescia - UOC Ematologia

Brescia, Italy
Careggi University Hospital - SOD Ematologia

Florence, Italy
Clinica Universidad De Navarra - Central Clinical Trials Unit

Pamplona, Spain
ErasmusMC, Rotterdam-Department of Hematology

Rotterdam, Netherlands
Fakultni Nemocnice Brno - Internal Hematology and Oncology Clinic

Brno, Czechia
Fakultni Nemocnice Hradec Kralove - 4th Department of Internal Medicine

Nový Hradec Králové, Czechia
Fakultni Nemocnice Ostrava - Department of Haematooncology

Ostrava, Czechia
Fondazione IRCCS Policlinico San Matteo-UOC Ematologia 1

Pavia, Italy
Haga Hospital - Internal Medicine - Hematology

s-Gravenweg, Netherlands
Het Ziekenhuisnetwerk Antwerpen - Department of Hematology

Antwerp, Belgium
Hospital Clinic De Barcelona - Myeloma and Amyloidosis Unit

Barcelona, Spain
Hospital Germans Trias I Pujol - Hematology Service ICO Badalona Clinic

Badalona, Spain
Hospital Universitario 12 De Octubre - Hematology

Madrid, Spain
Hospital Universitario 12 De Octubre -Hematology and Hemotherapy Service

Madrid, Spain
Hospital Universitario De Salamanca-Department of Hematology of the Salamanca University Care Complex

Salamanca, Spain
Hospital Universitario Marques De Valdecilla -Hematology and Hemotherapy Service

Santander, Spain
Klinikum rechts der Isar der TU Muenchen AöR - Innere Medizin III-Haematologie/Onkologie

München, Germany
Meander Medisch Centrum -Internal Medicine - Hematology

Amersfoort, Netherlands
Medical Center - University Of Freiburg - Department Innere Medizin Klinik für Innere Medizin I

Freiburg im Breisgau, Germany
Medisch Centrum Leeuwarden B.V. - Oncologisch Centrum Leeuwarden (OCL) and Internal Medicine - Hematology

Leeuwarden, Netherlands
Noordwest Ziekenhuisgroep Stichting - Internal Medicine - Hematology

Alkmaar, Netherlands
Oslo University Hospital HF - Oslo myelomatosesenter

Oslo, Norway
Sint Antonius Ziekenhuis Stichting-Internal Medicine - Hematology

Nieuwegein, Netherlands
St. Olavs Hospital HF - Department of Hematology

Trondheim, Norway
Theageneio General Hospital - Department of Hematology Oncology

Thessaloniki, Greece
Universitair Medisch Centrum Groningen-Department of Haematology

Groningen, Netherlands
University Hospital Consorziale Policlinico-U.O. di Ematologia con Trapianto

Bari, Italy
University Medical Center Hamburg-Eppendorf - Medizinische Klinik und Polikllinik Onkologie und Knochenmarktransplantation, Haematologie

Hamburg, Germany
Vseobecna Fakultni Nemocnice V Praze - Internal Medicine, Hematology Clinic

Prague, Czechia
Zuyderland Medisch Centrum Stichting - Internal Medicine - Hematology

Geleen, Netherlands

More trials for these conditions

Other studies related to the condition(s) this trial covers.