Immunotherapy duo takes on rare cancers
NCT ID NCT04969887
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This Phase 2 trial is testing whether combining two immunotherapy drugs, ipilimumab and nivolumab, can shrink or control rare cancers that are known to respond to immunotherapy. The study includes 240 people with advanced biliary tract, neuroendocrine, gynecologic, or MSI-H solid tumors (excluding colorectal cancer). Researchers aim to confirm the clinical benefit seen in an earlier study and measure how long patients live without their cancer growing.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ipilimumab and nivolumab (immune checkpoint inhibitors)
What this could lead to
If successful, this could provide an effective treatment option for several rare cancers that currently have limited therapies.
What could go wrong
This is a Phase 2 trial with a moderate number of participants, so results may not confirm benefit. Immune-related side effects from these drugs can be serious.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Auckland City Hospital
Auckland, New Zealand
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Austin Health
Heidelberg, Victoria, 3084, Australia
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Barwon Health
Geelong, Victoria, Australia
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Bendigo Health Services
Bendigo, Victoria, Australia
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Blacktown Hospital
Sydney, New South Wales, 2145, Australia
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Border Medical Oncology Unit
Albury, New South Wales, 2640, Australia
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Cairns and Hinterland Hospital and Health Service
Cairns, Queensland, 4870, Australia
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Calvary Mater Newcastle
Waratah, New South Wales, 2298, Australia
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Fiona Stanley Hospital
Perth, Western Australia, Australia
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Goulburn Valley Health
Shepparton, Victoria, 3630, Australia
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Orange Health Service
Orange, New South Wales, Australia
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Peninsula Health
Frankston, Victoria, Australia
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Peter MacCalllum Cancer Centre
Parkville, Victoria, Australia
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Royal Adelaide Hospital
Adelaide, South Australia, Australia
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Royal Hobart Hospital
Hobart, Tasmania, 7000, Australia
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South West Healthcare
Warrnambool, Victoria, Australia
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Townsville Hospital and Health Service
Douglas, Queensland, 4814, Australia
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Townville Hospital and Health Service
Townsville, Queensland, 4814, Australia