New drug combo aims to boost chemoradiation for head and neck cancer

NCT ID NCT05172245

First seen Nov 01, 2025

Summary

This early-phase study tests whether adding the experimental drug ipatasertib to standard chemotherapy and radiation is safe and effective for people with advanced head and neck cancer. Ipatasertib may help stop cancer cell growth. About 46 participants will receive the combination to find the best dose and check for side effects.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Atrium Health Cabarrus/LCI-Concord

    ACTIVE_NOT_RECRUITING

    Concord, North Carolina, 28025, United States

  • Carolinas Medical Center/Levine Cancer Institute

    ACTIVE_NOT_RECRUITING

    Charlotte, North Carolina, 28203, United States

  • Moffitt Cancer Center

    RECRUITING

    Tampa, Florida, 33612, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Montefiore Medical Center - Moses Campus

    RECRUITING

    The Bronx, New York, 10467, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Montefiore Medical Center-Einstein Campus

    RECRUITING

    The Bronx, New York, 10461, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Northwestern University

    RECRUITING

    Chicago, Illinois, 60611, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Rutgers Cancer Institute of New Jersey

    RECRUITING

    New Brunswick, New Jersey, 08903, United States

    Contact

    Contact Phone: •••-•••-••••

  • Rutgers New Jersey Medical School

    RECRUITING

    Newark, New Jersey, 07101, United States

    Contact

    Contact Phone: •••-•••-••••

  • University Health Network-Princess Margaret Hospital

    SUSPENDED

    Toronto, Ontario, M5G 2M9, Canada

  • University of Cincinnati Cancer Center-UC Medical Center

    RECRUITING

    Cincinnati, Ohio, 45219, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • University of Cincinnati Cancer Center-West Chester

    RECRUITING

    West Chester, Ohio, 45069, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • University of Kansas Cancer Center

    RECRUITING

    Kansas City, Kansas, 66160, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University of Kansas Clinical Research Center

    RECRUITING

    Fairway, Kansas, 66205, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University of Kansas Hospital-Westwood Cancer Center

    RECRUITING

    Westwood, Kansas, 66205, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University of Kentucky/Markey Cancer Center

    ACTIVE_NOT_RECRUITING

    Lexington, Kentucky, 40536, United States

  • University of Maryland/Greenebaum Cancer Center

    RECRUITING

    Baltimore, Maryland, 21201, United States

    Contact

    Contact Phone: •••-•••-••••

  • University of Virginia Cancer Center

    SUSPENDED

    Charlottesville, Virginia, 22908, United States

  • VCU Massey Comprehensive Cancer Center

    RECRUITING

    Richmond, Virginia, 23298, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

The condition(s) this trial relates to.

cancer of unknown primary site carcinoma head and neck squamous cell carcinoma hypopharyngeal carcinoma hypopharynx cancer hypopharynx squamous cell carcinoma laryngeal carcinoma laryngeal neoplasm laryngeal squamous cell carcinoma larynx cancer lip and oral cavity carcinoma lip and oral cavity squamous cell carcinoma maxillary sinus squamous cell carcinoma Mouth Neoplasms nasal cavity and paranasal sinus carcinoma nasal cavity squamous cell carcinoma oral cavity squamous cell carcinoma oropharyngeal carcinoma oropharynx cancer oropharynx squamous cell carcinoma paranasal sinus squamous cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.