New drug trial targets genetic cause of ALS
NCT ID NCT04768972
Summary
This study is testing an experimental drug called ION363 for people with ALS caused by specific mutations in the FUS gene. The drug is delivered via spinal injection and aims to slow the loss of physical function and improve survival. The trial will involve about 95 participants and includes an initial blinded phase followed by a longer open-label treatment period.
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Contacts and locations
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Locations
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Citta della Salute e della Scienza di Torino - Ospedale le Molinette
Torino, 10126, Italy
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Columbia University Medical Center
New York, New York, 10032, United States
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Hanyang University Seoul Hospital
Seoul, 4763, South Korea
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Hospital Universitari de Bellvitge
Barcelona, 8907, Spain
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Johns Hopkins University
Baltimore, Maryland, 21205, United States
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Kantonsspital St. Gallen
Sankt Gallen, 9007, Switzerland
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King's College Hospital
London, SE5 9RT, United Kingdom
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Linden spólka z ograniczona odpowiedzialnoscia spólka komandytow
Krakow, 30-721, Poland
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
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Montreal Neurological Institute
Montreal, Quebec, H3A 2B4, Canada
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PSEG Centro de Pesquisa Clinica S.A.
São Paulo, 04038-002, Brazil
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Seoul National University Hospital
Seoul, 3080, South Korea
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St. James Hospital
Dublin, D08 A978, Ireland
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Stanford University Medical Center
Palo Alto, California, 94304, United States
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Taipei Veterans General Hospital (VGHTP)
Taipei, 11217, Taiwan
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The Ohio State University Wexner Medical Center
Columbus, Ohio, 43210, United States
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Toho University Omori Medical Center
Tokyo, 143-8541, Japan
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UZ Leuven
Leuven, VL-Brabant, 3000, Belgium
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Universitaetsmedizin Rostock
Rostock, 18147, Germany
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Universitair Medisch Centrum Utrecht
Utrecht, 3584 CX, Netherlands
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University Hospital of Umea
Umeå, SE-901 85, Sweden
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University of California San Diego
La Jolla, California, 92037, United States
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University of Utah
Salt Lake City, Utah, 84132, United States
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Universitätsklinikum Ulm
Ulm, 89081, Germany
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Washington University School of Medicine
St Louis, Missouri, 63110, United States
Conditions
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