Radiation boosts CAR-T: new hope for tough lymphoma?
NCT ID NCT06768905
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether giving a single dose of a targeted radiation drug (Iomab-B) before standard CAR-T cell therapy can improve outcomes for people with relapsed or refractory diffuse large B-cell lymphoma. About 30 participants will receive the radiation followed by CAR-T cells. Researchers are checking for safety, side effects, and how well the cancer responds.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University of Texas Southwestern Medical Center
RECRUITINGDallas, Texas, 75390, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Iomab-B (targeted radiation) followed by CAR-T cell therapy
What this could lead to
If it works, this could make CAR-T therapy safer and more effective for people with hard-to-treat lymphoma, potentially leading to longer remissions.
What could go wrong
This is an early-phase trial with only 30 participants, so results may not apply broadly. The combination of radiation and cell therapy carries risks like severe immune reactions and organ damage.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.