Bone antibiotics: a new way to stop prosthetic infections?
NCT ID NCT07621094
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at whether giving antibiotics directly into the bone during surgery can prevent infections in people with osseointegration implants (a type of prosthetic that attaches directly to the bone). About 100 adults who already have or are getting these implants will receive vancomycin through a small tube in the bone during their operation. Researchers will track wound healing, infections, and any side effects for one year to see if this approach is safe and effective.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- vancomycin (antibiotic)
- What this could lead to
- If it works, this could offer a better way to prevent and treat infections in people with bone-anchored prosthetics, reducing the need for implant removal.
- What could go wrong
- This is an early-stage study with no comparison group, so it is unclear if the antibiotic delivery method is truly effective. There are also risks of antibiotic side effects like allergic reactions or kidney problems.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Atrium Health Carolinas Medical Center
Charlotte, North Carolina, 28203, United States
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Hospital for Special Surgery
New York, New York, 10021, United States
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UT Health San Antonio
San Antonio, Texas, 78229, United States
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University of Colorado Anschutz Medical Campus
Aurora, Colorado, 80045, United States
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University of Pennsylvania Perelman School of Medicine
Philadelphia, Pennsylvania, 19104, United States