Bone injection may boost antibiotic power in hip surgery

This study tests whether giving antibiotics directly into the bone (intraosseous) during hip replacement surgery can increase antibiotic levels in blood and tissue compared to standard IV antibiotics alone. About 25 adults having a first-time hip replacement will receive either the bone injection plus IV antibiotics or a placebo injection plus IV antibiotics. Researchers will measure antibiotic concentrations and track any complications for 90 days after surgery.