Double attack on brain metastases: new combo therapy shows promise for lung cancer patients
NCT ID NCT06304441
First seen Nov 01, 2025 · Last updated May 15, 2026 · Updated 30 times
Summary
This study tests whether adding a chemotherapy drug (pemetrexed) directly into the spinal fluid to a standard targeted therapy pill (like osimertinib) works better than the pill alone for people with a specific type of lung cancer that has spread to the lining of the brain or spinal cord. About 100 adults aged 18-75 with EGFR-mutant non-small cell lung cancer and confirmed leptomeningeal metastasis will be enrolled. The goal is to see if the combination improves response and survival while monitoring side effects.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for LEPTOMENINGEAL METASTASIS are added.
By submitting, you agree to our Terms of use
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
The Third People's Hospital of Huizhou (Huizhou Hospital of Guangzhou Medical University)
RECRUITINGHuizhou, Guangdong, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Conditions
Explore the condition pages connected to this study.