Experimental drug aims to shield ICU patients from deadly infections

NCT ID NCT06774235

Recruiting now Disease control Sponsor: University Hospital, Limoges Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 trial tests whether a drug called interferon gamma can prevent secondary infections in ICU patients whose immune systems are suppressed. About 326 adults who have been in the ICU for at least a week and show signs of immune weakness will receive either the drug or a placebo. The goal is to see if the drug reduces infection rates and improves recovery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Interferon gamma 1-b
What this could lead to: If it works, this could reduce dangerous secondary infections in ICU patients with weakened immune systems, potentially saving lives and shortening hospital stays.
What could go wrong: This is a phase 3 trial, but the treatment is given for only a short time and may not work for everyone. There is also a risk of side effects from the drug.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

coinfection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SUSTAINED IMMUNOSUPPRESSION

Contacts and locations

Locations

APHM
RECRUITING

Marseille, 13915, France
APHP - Cochin
RECRUITING

Paris, 75015, France
APHP - Laroiboisière
RECRUITING

Paris, 75010, France
APHP - Raymond Poincaré
RECRUITING

Garches, 92380, France
Angers university hospial
RECRUITING

Angers, 49100, France
Aphp - Hegp
RECRUITING

Paris, 75014, France
Argenteuil hospital
RECRUITING

Argenteuil, 95107, France
Brive Hospital
RECRUITING

Brive-la-Gaillarde, 19100, France
CH de Lens
RECRUITING

Lens, 62300, France
Chalon sur saone Hospital
RECRUITING

Chalon-sur-Saône, 71100, France
Dijon University Hospital
RECRUITING

Dijon, 21000, France
Franche-comté north Hospital
RECRUITING

Belfort, 90015, France
Le mans Hospital
RECRUITING

Le Mans, 72000, France
Limoges University Hospital
RECRUITING

Limoges, 87042, France
Lyon Civils Hospices
NOT_YET_RECRUITING

Lyon, 69002, France
Melun Hospital
RECRUITING

Melun, 77000, France
Nancy University Hospital
RECRUITING

Nancy, 54035, France
Nantes University Hospital
RECRUITING

Nantes, 44000, France
Orléans Hospital
RECRUITING

Orléans, 45100, France
Rennes University Hospital
RECRUITING

Rennes, 35000, France
Strasbourg University Hospital
RECRUITING

Strasbourg, 67091, France
Tours University Hospital
RECRUITING

Tours, 37000, France
Versailles Hospital
RECRUITING

Le Chesnay, 78157, France