Heart failure drug combo: start both at once or one at a time?

NCT ID NCT05989503

First seen Nov 19, 2025 · Last updated May 15, 2026 · Updated 26 times

Summary

This study looked at the safest way to start two common heart failure drugs (ARNi and SGLT2i) in 62 adults with a weak heart pump. Some patients started both drugs at the same time, while others started one drug first and added the second later. The goal was to see which approach caused fewer side effects like low blood pressure, kidney problems, or hospital visits.

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Contacts and locations

Locations

  • Centro Hospitalar Universitário São João

    Porto, 4200-319, Portugal

  • Centro Hospitalar Universitário de Santo António

    Porto, Porto District, 4099-001, Portugal

  • Centro Hospitalar Vila Nova de Gaia/Espinho

    Porto, 4434-502, Portugal

  • Faculty of Medicine (FMUP)

    Porto, 4200-319, Portugal

  • Unidade Local de Saúde de Matosinhos - Hospital Pedro Hispano

    Porto, Portugal

Conditions

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