New combo aims to wipe out aggressive breast cancer before surgery

NCT ID NCT07245797

First seen Jan 04, 2026 · Last updated May 14, 2026 · Updated 26 times

Summary

This study tests whether adding the drug inavolisib to standard targeted therapy and chemotherapy can eliminate more breast cancer before surgery in people with a specific genetic mutation (PIK3CA) and HER2-positive early breast cancer. About 164 participants will receive either the standard treatment or the standard plus inavolisib for 6 cycles, then have surgery to check if the cancer is gone. The goal is to see if the new combination improves the chance of having no cancer left at surgery.

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