Two drugs vs. one: new hope for Tough-to-Treat uterine cancer

NCT ID NCT05112601

Recruiting now Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

Summary

This study is for people whose endometrial (uterine) cancer has returned after treatment. It compares two different immunotherapy approaches to see which is better at controlling the cancer. One group gets a single immunotherapy drug (nivolumab), while the other gets a combination of two drugs (nivolumab and ipilimumab). The trial focuses on cancers with a specific genetic feature (dMMR) that may make them more responsive to immunotherapy.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Abbott-Northwestern Hospital
RECRUITING

Minneapolis, Minnesota, 55407, United States

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Arnold Palmer Cancer Center Medical Oncology Norwin
RECRUITING

N. Huntingdon, Pennsylvania, 15642, United States

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Augusta University Medical Center
RECRUITING

Augusta, Georgia, 30912, United States

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Beacon Kalamazoo Cancer Center
RECRUITING

Kalamazoo, Michigan, 49009, United States

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Benefis Sletten Cancer Institute
RECRUITING

Great Falls, Montana, 59405, United States

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Billings Clinic Cancer Center
RECRUITING

Billings, Montana, 59101, United States

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Bozeman Health Deaconess Hospital
RECRUITING

Bozeman, Montana, 59715, United States

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Bronson Battle Creek
RECRUITING

Battle Creek, Michigan, 49017, United States

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Bronson Methodist Hospital
RECRUITING

Kalamazoo, Michigan, 49007, United States

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Cancer and Hematology Centers of Western Michigan - Norton Shores
RECRUITING

Norton Shores, Michigan, 49444, United States

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Carle BroMenn Medical Center
RECRUITING

Normal, Illinois, 61761, United States

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Carle Cancer Center
RECRUITING

Urbana, Illinois, 61801, United States

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Carle Cancer Institute Normal
RECRUITING

Normal, Illinois, 61761, United States

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Carle Physician Group-Effingham
RECRUITING

Effingham, Illinois, 62401, United States

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Carle Physician Group-Mattoon/Charleston
RECRUITING

Mattoon, Illinois, 61938, United States

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Carle at The Riverfront
RECRUITING

Danville, Illinois, 61832, United States

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Case Western Reserve University
RECRUITING

Cleveland, Ohio, 44106, United States

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Cleveland Clinic Cancer Center/Fairview Hospital
RECRUITING

Cleveland, Ohio, 44111, United States

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Cleveland Clinic Foundation
RECRUITING

Cleveland, Ohio, 44195, United States

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Community Hospital of Anaconda
RECRUITING

Anaconda, Montana, 59711, United States

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Community Medical Center
RECRUITING

Missoula, Montana, 59804, United States

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Corewell Health Grand Rapids Hospitals - Butterworth Hospital
RECRUITING

Grand Rapids, Michigan, 49503, United States

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Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
RECRUITING

Saint Joseph, Michigan, 49085, United States

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Corewell Health Lakeland Hospitals - Niles Hospital
RECRUITING

Niles, Michigan, 49120, United States

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Corewell Health Lakeland Hospitals - Saint Joseph Hospital
RECRUITING

Saint Joseph, Michigan, 49085, United States

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Corewell Health Reed City Hospital
RECRUITING

Reed City, Michigan, 49677, United States

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Duke University Medical Center
RECRUITING

Durham, North Carolina, 27710, United States

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Duke Women's Cancer Care Raleigh
RECRUITING

Raleigh, North Carolina, 27607, United States

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Duluth Clinic Ashland
RECRUITING

Ashland, Wisconsin, 54806, United States

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Essentia Health - Deer River Clinic
RECRUITING

Deer River, Minnesota, 56636, United States

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Essentia Health Cancer Center
RECRUITING

Duluth, Minnesota, 55805, United States

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Essentia Health Cancer Center-South University Clinic
RECRUITING

Fargo, North Dakota, 58103, United States

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Essentia Health Hibbing Clinic
RECRUITING

Hibbing, Minnesota, 55746, United States

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Essentia Health Sandstone
RECRUITING

Sandstone, Minnesota, 55072, United States

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Essentia Health Virginia Clinic
RECRUITING

Virginia, Minnesota, 55792, United States

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Fairview Southdale Hospital
RECRUITING

Edina, Minnesota, 55435, United States

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Fred Hutchinson Cancer Center
ACTIVE_NOT_RECRUITING

Seattle, Washington, 98109, United States
Geauga Hospital
RECRUITING

Chardon, Ohio, 44024, United States

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Good Samaritan Hospital - Cincinnati
RECRUITING

Cincinnati, Ohio, 45220, United States

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Henrico Doctor's Hospital
RECRUITING

Richmond, Virginia, 23229, United States

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Hillcrest Hospital Cancer Center
RECRUITING

Mayfield Heights, Ohio, 44124, United States

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IRMC Cancer Center
RECRUITING

Indiana, Pennsylvania, 15701, United States

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IU Health North Hospital
RECRUITING

Carmel, Indiana, 46032, United States

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Indiana University/Melvin and Bren Simon Cancer Center
RECRUITING

Indianapolis, Indiana, 46202, United States

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Intermountain Health West End Clinic
RECRUITING

Billings, Montana, 59106, United States

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Kootenai Clinic Cancer Services - Post Falls
RECRUITING

Post Falls, Idaho, 83854, United States

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Kootenai Clinic Cancer Services - Sandpoint
RECRUITING

Sandpoint, Idaho, 83864, United States

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Kootenai Health - Coeur d'Alene
RECRUITING

Coeur d'Alene, Idaho, 83814, United States

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Logan Health Medical Center
RECRUITING

Kalispell, Montana, 59901, United States

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MU Health - University Hospital/Ellis Fischel Cancer Center
RECRUITING

Columbia, Missouri, 65212, United States

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MaineHealth Maine Medical Center- Scarborough
RECRUITING

Scarborough, Maine, 04074, United States

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Mercy Hospital
RECRUITING

Coon Rapids, Minnesota, 55433, United States

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Miami Valley Hospital South
RECRUITING

Centerville, Ohio, 45459, United States

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Miller-Dwan Hospital
RECRUITING

Duluth, Minnesota, 55805, United States

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Munson Medical Center
RECRUITING

Traverse City, Michigan, 49684, United States

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Nebraska Methodist Hospital
RECRUITING

Omaha, Nebraska, 68114, United States

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Northwest Cancer Center - Hobart
RECRUITING

Hobart, Indiana, 46342, United States

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Northwest Cancer Center - Main Campus
RECRUITING

Crown Point, Indiana, 46307, United States

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Northwest Cancer Center - Valparaiso
RECRUITING

Valparaiso, Indiana, 46383, United States

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Northwest Oncology LLC
RECRUITING

Dyer, Indiana, 46311, United States

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Northwest Wisconsin Cancer Center
RECRUITING

Ashland, Wisconsin, 54806, United States

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Ohio State University Comprehensive Cancer Center
RECRUITING

Columbus, Ohio, 43210, United States

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Oklahoma Cancer Specialists and Research Institute-Tulsa
RECRUITING

Tulsa, Oklahoma, 74146, United States

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Park Nicollet Clinic - Saint Louis Park
RECRUITING

Saint Louis Park, Minnesota, 55416, United States

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Parkland Memorial Hospital
RECRUITING

Dallas, Texas, 75235, United States

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Providence Portland Medical Center
RECRUITING

Portland, Oregon, 97213, United States

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Providence Saint Vincent Medical Center
RECRUITING

Portland, Oregon, 97225, United States

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Regions Hospital
RECRUITING

Saint Paul, Minnesota, 55101, United States

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Roswell Park Cancer Institute
ACTIVE_NOT_RECRUITING

Buffalo, New York, 14263, United States
Saint Alphonsus Cancer Care Center-Boise
SUSPENDED

Boise, Idaho, 83706, United States
Saint Alphonsus Cancer Care Center-Caldwell
SUSPENDED

Caldwell, Idaho, 83605, United States
Saint Alphonsus Cancer Care Center-Nampa
SUSPENDED

Nampa, Idaho, 83687, United States
Saint Alphonsus Cancer Care Center-Ontario
SUSPENDED

Ontario, Oregon, 97914, United States
Saint Catherine Hospital
RECRUITING

Indianapolis, Indiana, 46312, United States

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Saint Francis Regional Medical Center
RECRUITING

Shakopee, Minnesota, 55379, United States

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Saint Luke's Cancer Institute - Boise
RECRUITING

Boise, Idaho, 83712, United States

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Saint Luke's Cancer Institute - Fruitland
RECRUITING

Fruitland, Idaho, 83619, United States

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Saint Luke's Cancer Institute - Meridian
RECRUITING

Meridian, Idaho, 83642, United States

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Saint Luke's Cancer Institute - Nampa
RECRUITING

Nampa, Idaho, 83687, United States

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Saint Mary Medical Center
RECRUITING

Hobart, Indiana, 46342, United States

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Saint Vincent Frontier Cancer Center
RECRUITING

Billings, Montana, 59102, United States

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State University of New York Upstate Medical University
RECRUITING

Syracuse, New York, 13210, United States

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Swedish Cancer Institute-Edmonds
RECRUITING

Edmonds, Washington, 98026, United States

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Swedish Cancer Institute-Issaquah
RECRUITING

Issaquah, Washington, 98029, United States

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Swedish Medical Center-First Hill
RECRUITING

Seattle, Washington, 98122, United States

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The Community Hospital
RECRUITING

Munster, Indiana, 46321, United States

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The James Graham Brown Cancer Center at University of Louisville
RECRUITING

Louisville, Kentucky, 40202, United States

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Trinity Health Grand Rapids Hospital
RECRUITING

Grand Rapids, Michigan, 49503, United States

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Trinity Health Muskegon Hospital
RECRUITING

Muskegon, Michigan, 49444, United States

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UH Seidman Cancer Center at Lake Health Mentor Campus
RECRUITING

Mentor, Ohio, 44060, United States

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UH Seidman Cancer Center at Saint John Medical Center
RECRUITING

Westlake, Ohio, 44145, United States

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UHHS-Chagrin Highlands Medical Center
RECRUITING

Beachwood, Ohio, 44122, United States

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UPMC Cancer Center at UPMC Horizon
RECRUITING

Farrell, Pennsylvania, 16121, United States

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UPMC Cancer Center at UPMC McKeesport
RECRUITING

McKeesport, Pennsylvania, 15132, United States

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UPMC Cancer Center at UPMC Northwest
RECRUITING

Seneca, Pennsylvania, 16346, United States

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UPMC Cancer Center-Natrona Heights
RECRUITING

Natrona Heights, Pennsylvania, 15065, United States

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UPMC Cancer Center-Washington
RECRUITING

Washington, Pennsylvania, 15301, United States

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UPMC Cancer Centers - Arnold Palmer Pavilion
RECRUITING

Greensburg, Pennsylvania, 15601, United States

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UPMC Hillman Cancer Center - Monroeville
RECRUITING

Monroeville, Pennsylvania, 15146, United States

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UPMC Hillman Cancer Center - New Castle
RECRUITING

New Castle, Pennsylvania, 16105, United States

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UPMC Hillman Cancer Center - Part of Frick Hospital
RECRUITING

Mount Pleasant, Pennsylvania, 15666, United States

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UPMC Hillman Cancer Center - Passavant - Cranberry
RECRUITING

Cranberry Township, Pennsylvania, 16066, United States

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UPMC Hillman Cancer Center Erie
RECRUITING

Erie, Pennsylvania, 16505, United States

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UPMC Hillman Cancer Center at Butler Health System
RECRUITING

Butler, Pennsylvania, 16001, United States

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UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
RECRUITING

Mechanicsburg, Pennsylvania, 17050, United States

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UPMC Hillman Cancer Center in Coraopolis
RECRUITING

Moon Township, Pennsylvania, 15108, United States

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UPMC West Mifflin-Cancer Center Jefferson
RECRUITING

West Mifflin, Pennsylvania, 15122, United States

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UPMC-Heritage Valley Health System Beaver
RECRUITING

Beaver, Pennsylvania, 15009, United States

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UPMC-Johnstown/John P. Murtha Regional Cancer Center
RECRUITING

Johnstown, Pennsylvania, 15901, United States

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UPMC-Magee Womens Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States

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UPMC-Mercy Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15219, United States

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UPMC-Passavant Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15237, United States

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UPMC-Saint Clair Hospital Cancer Center
RECRUITING

Pittsburgh, Pennsylvania, 15243, United States

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UPMC-Saint Margaret
RECRUITING

Pittsburgh, Pennsylvania, 15215, United States

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UT Southwestern Clinical Center at Richardson/Plano
RECRUITING

Richardson, Texas, 75080, United States

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UT Southwestern/Simmons Cancer Center-Dallas
RECRUITING

Dallas, Texas, 75390, United States

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UT Southwestern/Simmons Cancer Center-Fort Worth
RECRUITING

Fort Worth, Texas, 76104, United States

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United Hospital
RECRUITING

Saint Paul, Minnesota, 55102, United States

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University Cancer and Blood Center LLC
RECRUITING

Athens, Georgia, 30607, United States

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University Hospitals Parma Medical Center
RECRUITING

Parma, Ohio, 44129, United States

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University of Alabama at Birmingham Cancer Center
RECRUITING

Birmingham, Alabama, 35233, United States

Contact

Contact Email: •••••@•••••
University of Illinois
RECRUITING

Chicago, Illinois, 60612, United States

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University of Iowa/Holden Comprehensive Cancer Center
RECRUITING

Iowa City, Iowa, 52242, United States

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University of Michigan Health - West
RECRUITING

Wyoming, Michigan, 49519, United States

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University of New Mexico Cancer Center
RECRUITING

Albuquerque, New Mexico, 87106, United States

Contact

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University of Oklahoma Health Sciences Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States

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University of Pittsburgh Cancer Institute (UPCI)
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States

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University of Rochester
RECRUITING

Rochester, New York, 14642, United States

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University of Virginia Cancer Center
RECRUITING

Charlottesville, Virginia, 22908, United States

Contact

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UofL Health Medical Center Northeast
RECRUITING

Louisville, Kentucky, 40245, United States

Contact

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VCU Massey Comprehensive Cancer Center
RECRUITING

Richmond, Virginia, 23298, United States

Contact

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Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States

Contact

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West Michigan Cancer Center
RECRUITING

Kalamazoo, Michigan, 49007, United States

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Wilmot Cancer Institute at Webster
RECRUITING

Webster, New York, 14580, United States

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Contact Email: •••••@•••••
Women and Infants Hospital
RECRUITING

Providence, Rhode Island, 02905, United States

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Contact Phone: •••-•••-••••
Women's Cancer Center of Nevada
RECRUITING

Las Vegas, Nevada, 89106, United States

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Contact Phone: •••-•••-••••
Women's Diagnostic Center - Munster
RECRUITING

Munster, Indiana, 46321, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

Explore the condition pages connected to this study.

ENDOMETRIAL ADENOCARCINOMA ENDOMETRIAL CLEAR CELL ADENOCARCINOMA ENDOMETRIAL DEDIFFERENTIATED CARCINOMA ENDOMETRIAL ENDOMETRIOID ADENOCARCINOMA ENDOMETRIAL MIXED CELL ADENOCARCINOMA ENDOMETRIAL MUCINOUS ADENOCARCINOMA ENDOMETRIAL UNDIFFERENTIATED CARCINOMA ENDOMETRIOID ADENOCARCINOMA RECURRENT ENDOMETRIAL CARCINOMA