Spinal injection combo shows promise for deadly brain lining cancer spread
NCT ID NCT06462222
First seen Oct 31, 2025 · Last updated May 24, 2026 · Updated 32 times
Summary
This study tests a new treatment for people whose cancer has spread to the thin layer covering the brain and spinal cord (leptomeningeal metastasis). The treatment combines an immune-boosting drug (immune checkpoint inhibitor) with a chemotherapy drug (pemetrexed), both injected directly into the spinal fluid. The goal is to find the safest dose and see if it helps control the disease. The study includes 45 adults aged 18-75 with solid tumors and positive spinal fluid tests.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Beijing Chest Hospital, Capital Medical University
Beijing, 101100, China
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Cancer Center, Aerospace Center Hospital, Peking University Aerospace School of Clinical Medicine
Beijing, China
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Huizhou First Hospital Affiliated to Guangdong Medical University
Huizhou, Guangdong, China
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The Affiliated Huizhou Hospital, Guangzhou Medical University
Huizhou, Guangdong, 516000, China
Conditions
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