New hope for myelofibrosis patients who fail current treatments
NCT ID NCT04576156
First seen Jun 27, 2026 · Last updated Jul 09, 2026 · Updated 2 times
Summary
This phase 3 trial tests a drug called imetelstat against the best available treatments for people with advanced myelofibrosis whose disease has stopped responding to JAK inhibitors. The study includes 327 participants and aims to see if imetelstat can help them live longer and feel better. The drug is given intravenously every three weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- imetelstat
- What this could lead to
- If successful, imetelstat could offer a new treatment option that extends survival and reduces symptoms for people with advanced myelofibrosis who have stopped responding to current therapies.
- What could go wrong
- This is a late-stage trial, but the drug may still fail to improve survival or cause significant side effects. Results may not apply to all patients with myelofibrosis.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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A.O.di Bologna Policl.S.Orsola
Bologna, Bologna, 40138, Italy
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AOU Careggi
Florence, Firenze, 50134, Italy
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AOU Città della Salute e della Scienza di Torino
Torino, Torino, 10126, Italy
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AOU Federico II
Naples, 80122, Italy
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AOU San Luigi Gonzaga
Orbassano, Torino, 10043, Italy
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ASL Roma 2 - PO "S. Eugenio"
Roma, 00144, Italy
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ASST Grande Ospedale Metropoli
Milan, 20162, Italy
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AUSL di Rimini Ospedale Infermi di Rimini
Rimini, Rimini, 47900, Italy
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AZ Klina
Antwerp, Antwerpen, 2930, Belgium
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All India Institute of Medical Sciences
Bhubaneswar, Odisha, 751019, India
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All India Institute of Medical Sciences, Dept. of Hematology, New Delhi (All India Institute Of Medical Sciences)
New Delhi, National Capital Territory of Delhi, 110029, India
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Ankara University Medical Facu
Ankara, Ankara, 6590, Turkey (Türkiye)
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Arcispedale S Maria Nuova, AO di Reggio Emilia
Reggio Calabria, Reggio Calabria, 42123, Italy
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Arcispedale S.Anna - Ematologi
Cona, Ferrara, 44124, Italy
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Ars Medical Sp. z o.o.
Piła, Greater Poland Voivodeship, 64-920, Poland
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Assuta Ashdod University Hospi
Ashdod, Southern District, 7747629, Israel
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Azienda Ospedaliera Bianchi-Me
Reggio Calabria, Reggio Calabria, 89124, Italy
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Azienda Ospedaliera San Gerard
Monza, 20900, Italy
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BRCR Medical Center Inc
Plantation, Florida, 33326, United States
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Barzilai Medical Center
Ashkelon, Southern District, 78278, Israel
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Bnai Zion Medical Center
Haifa, 31048, Israel
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Budgetary Healthcare Institution of Omsk Region
Omsk, 644013, Russia
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CEPON Centro de Pesquisas Oncologicas SC
Florianópolis, 88034-000, Brazil
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CHRU Brest - Hôpital Morvan
Brest, 29609, France
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CHU - Hôpital Saint Louis - Centre D'Investigations Cliniq
Paris, 75010, France
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CHU Bretonneau
Tours, Indre-et-Loire, 37044, France
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CHU De Nantes - Hematologie
Nantes, Loire-Atlantique, 44000, France
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CHU de Nice - Hopital de l'Archet II - Pharmacie
Nice, Nice Cedex 3, 06202, France
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Carmel MC
Haifa, 3436212, Israel
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Centre Hospitalier Du Mans - Cancérologie Médicale
Le Mans, Sarthe, 72037, France
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Centre Hospitalier Lyon
Pierre-Bénite, Auvergne-Rhône-Alpes, 69495, France
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Centre Hospitalier de Jolimont
Haine-Saint-Paul, Hainaut, 7100, Belgium
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Centro Clinico Fundacao Champalimaud
Lisbon, Lisbon District, 1400-038, Portugal
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Centro Gaucho Integrado de Oncologia, Hematologia, Ensino e Pesquisa LTDA
Porto Alegre, Rio Grande do Sul, 90470340, Brazil
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Centro de oncologia Leonardo da Vinci
Fortaleza, Ceará, 60135285, Brazil
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Centrum Medyczne Pratia Poznan
Skórzewo, Greater Poland Voivodeship, 60-185, Poland
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Chang Gung Medical Foundation
Chiayi City, Chiayi, 613, Taiwan
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China Medical University Hospital - Hematology/Onc
Taichung, 404, Taiwan
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Clinica Ematologica, Univ. Deg
Genova, Genova, 6- 16132, Italy
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Deenanath Mangeshkar Hospital & Research Center
Pune, 411004, India
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Duke University Medical Center
Durham, North Carolina, 27710, United States
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Dél-pesti Centrumkórház Ország
Budapest, H-1097, Hungary
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Ege Universitesi Tip Fakultesi
Izmir, İzmir, 35100, Turkey (Türkiye)
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Epworth Healthcare
Richmond, Victoria, 3121, Australia
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Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Milan, Milano, 20122, Italy
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Fortis Hospital 154/9
Bengaluru, Karnataka, 560076, India
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Fortis Memorial Research Institute
Gurgaon, New Delhi, 122002, India
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Fundacao Doutor Amaral Carvalho / Hospital Amaral Carvalho
São Paulo, São Paulo, 17210-120, Brazil
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GOU VPO Saratov State Medical University n.a. V.I.
Saratov, 410012, Russia
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Gabrail Cancer Center
Canton, Ohio, 44718, United States
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Gazi University Medical Faculty
Ankara, 06560, Turkey (Türkiye)
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Guys and St Thomas' Hospital
London, SE1 9RT, United Kingdom
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H. Quirón Zaragoza
Zaragoza, Zaragoza, 50012, Spain
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H. San Pedro de Alcántara
Cáceres, Cáceres, 10003, Spain
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H.G.U. Alicante
Alicante, Alicante, 03010, Spain
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H.U. La Paz
Madrid, Madrid, 28046, Spain
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H.U.V. de la Victoria
Málaga, Málaga, 29010, Spain
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Hadassah Medical Organization
Jerusalem, Jerusalem, 9112001, Israel
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Hopital Bicetre
Paris, Le Kremlin-Bicêtre, 94270, France
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Hospital A.C.Camargo Cancer Center - Clinical Oncology
São Paulo, Brazil
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Hospital Aleman
Ciudad de Buenos Aires, Buenos Aires, C118AAT, Argentina
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Hospital Ampang
Ampang, Selangor, 68000, Malaysia
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Hospital Erasto Gaertner
Curitiba, Paraná, 81520-060, Brazil
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Hospital Israelita Albert Einstein
São Paulo, São Paulo, 05651-901, Brazil
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Hospital Pablo Tobon Uribe
Antioquia, Colombia
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Hospital Pulau Pinang
Pulau Pinang, Georgetown, 10990, Malaysia
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Hospital Raja Perempuan Zainab II
Kota Bharu, Kelantan, 15586, Malaysia
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Hospital Sultanah Aminah Johor Bahru
Johor Bahru, Johor, 80000, Malaysia
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Hospital U. 12 Octubre
Madrid, Madrid, 28041, Spain
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Hospital Universitario Virgen
Granada, Granada, 18014, Spain
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Hospital Universitario de Gran
Las Palmas de Gran Canaria, Canary Islands, 35019, Spain
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Hospital das Clínicas UFG
Goiânia, Goiás, 74605, Brazil
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Hospital de Clinicas de Porto Alegre - UFRGS
Porto Alegre, Rio Grande do Sul, 90035-903, Brazil
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Icahn School of Medicine at Mount Sinai
New York, New York, 10029, United States
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Inje University Busan Paik Hos
Busan, Busan Gwang'Yeogsi [Pusan-Kwangyokshi], 47392, South Korea
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Inje University Haeundae Paik Hospital
Busan, Busan Gwang'Yeogsi [Pusan-Kwangyokshi], 48108, South Korea
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Institut Català d'Oncologia-Ho
Badalona, Barcelona, 08916, Spain
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Irccs Irst
Meldola, 47014, Italy
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Istanbul üniversitesi cerrahpaşa
Istanbul, Istanbul, 34098, Turkey (Türkiye)
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J.S.C."K.Eristavi National Cen
Tbilisi, K'alak'i T'bilisi, 0159, Georgia
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Kaplan Medical Center
Rehovot, Central District, 7610001, Israel
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Kepler Universitätsklinikum Gm
Linz, Upper Austria, 4021, Austria
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Klinikum Wels-Grieskirchen GmbH
Wels, Upper Austria, 4600, Austria
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Krankenhaus Hietzing mit Neurologischem Zentrum Rosenhügel
Wein, Burgenland, 1130, Austria
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Krankenhaus der Elisabethinen
Linz, Upper Austria, 4020, Austria
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LTD Israeli-Georgian Medical R
Tbilisi, 0112, Georgia
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Ltd "Medinvest - Institute of Hematology and Trans
Tbilisi, K'alak'i T'bilisi, 186, Georgia
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M.Zodelava Hematology Center L
Tbilisi, 0112, Georgia
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MONIKI - Oncology
Moscow, Moscow Oblast, 129110, Russia
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MUZ City Clinical Hospital # 2
Novosibirsk, Novosibirsk Oblast, 630091, Russia
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Marmara university pendik training and research hospital
Istanbul, Istanbul, 34899, Turkey (Türkiye)
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Martin-Luther-Universität Halle-Wittenberg
Halle, Saxony-Anhalt, 6120, Germany
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Medical Park Mersin Hastanesi
Mersin, Mersin, Turkey (Türkiye)
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Medipol Bagcilar Mega Hospital
Istanbul, Istanbul, 34214, Turkey (Türkiye)
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Multi Profile Clinic Consilium
Tbilisi, 0179, Georgia
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National University Cancer Institute (NCIS)
Singapore, Central Singapore, 119074, Singapore
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Nilratan Sircar Medical College
Kolkata, West Bengal, 700014, India
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Nirmal Hospital - Hematology
Surat, Gujarat, 395002, India
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Northwest Medical Specialties PLLC
Seattle, Washington, 98405, United States
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Norton Cancer Institute
Louisville, Kentucky, 40207, United States
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Odense University Hospital - Hematology
Odense, DK-5000 C, Denmark
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Oncologos del Occidente S.A
Pereira, Risaralda Department, 660000, Colombia
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Ospedale Civile S.Maria delle Croci, AUSL Ravenna
Ravenna, Ravenna, 48121, Italy
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Ospedale S.Bortolo, AULSS n.6
Vicenza, Vicenza, 36100, Italy
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Ospedale di Circolo, PO Varese
Varese, Varese, 21100, Italy
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Oxford University Hospitals
Oxford, OX3 9DS, United Kingdom
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PO Civile SS.Antonio e Biagio
Alessandria, Alessandria, 15121, Italy
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Policlinico Universitario Agostino Gemelli
Roma, Roma, 00168, Italy
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Prairie Lakes Health Care System, Inc.
Watertown, South Dakota, 57201, United States
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Pratia Onkologia Katowice
Katowice, Silesian Voivodeship, 40-519, Poland
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Presidio Ospedaliero Garibaldi
Catania, 95122, Italy
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Royal Brisbane and Women's Hospital
Herston, Queensland, 4011, Australia
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Royal Hobart Hospital
Hobart, Tasmania, 7000, Australia
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Royal North Shore Hospital
St Leonards, New South Wales, 2065, Australia
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Sahyadri Specialty Hospital
Pune, India
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Sakarya Research and Training Hospital - Medical Oncology
Adapazarı, 54100, Turkey (Türkiye)
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Sanatorio Allende
Córdoba, X5000JHQ, Argentina
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Sanatorio de la Mujer
Rosario, Santa Fe Province, S2000ORE, Argentina
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Sarawak General Hospital
Kuching, Sarawak, 93586, Malaysia
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Seoul National University Hospital - Department of Internal
Seoul, Seoul Teugbyeolsi [Seoul-T'Ukp, 03080, South Korea
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Severance Hospital, Yonsei Uni
Seoul, 3722, South Korea
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Shamir Medical Center (Assaf Harofeh)
Ẕerifin, Central District, 7030000, Israel
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Singapore General Hospital
Singapore, Central Singapore, 169608, Singapore
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Sir Ganga Ram Hospital
New Delhi, National Capital Territory of Delhi, 110060, India
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Smilow Cancer Center at YNHH
New Haven, Connecticut, 06511, United States
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Soroka Medical Center - Hematology Institute
Beersheba, 84101, Israel
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Specialized Hospital for Active Therapy of Hematological dis
Sofia, Sofia, 1756, Bulgaria
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St Bartholomew's Hospital
London, EC1A 7BE, United Kingdom
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St. John's Medical College Hospital
Bangalore, Karnataka, 560 034, India
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Szabolcs-Szatmár-Bereg Megyei Önkormányzat Jósa András
Nyíregyháza, 4400, Hungary
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The Catholic University of Korea
Seongdong, 6591, South Korea
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The University of Texas MD
Houston, Texas, 77030-4000, United States
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UCLA David Geffen School of Medicine
Los Angeles, California, 90096, United States
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UMBAL Sveti Georgi
Plovdiv, Plovdiv, 4002, Bulgaria
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UZ Antwerpen
Edegem, Antwerpen, 2650, Belgium
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Universitair Ziekenhuis Brussel - Myeloom Centrum Brussel (MCB)
Jette, Belgium
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Universitair Ziekenhuis Gent
Ghent, Oost-Vlaanderen, 9000, Belgium
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University of California-San Diego/Moores UCSD Cancer Center
La Jolla, California, 92093-1503, United States
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University of South Florida
Tampa, Florida, 33612, United States
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Universitätsklinikum Carl Gust
Dresden, Free and Hanseatic City of Hamburg, 1307, Germany
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Universitätsklinikum Leipzig AöR
Leipzig, Saxony, 04103, Germany
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Universitätsklinikum Mannheim - University of Heidelberg
Mannheim, Baden-Wurttemberg, 68167, Germany
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Universitätsklinikum Tübingen
Tübingen, Baden-Wurttemberg, 72076, Germany
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Wojewodzki Szpital Specjalistyczny
Biała Podlaska, 21-500, Poland
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