New hope for myelofibrosis patients who fail current treatments

NCT ID NCT04576156

First seen Jun 27, 2026 · Last updated Jul 09, 2026 · Updated 2 times

Summary

This phase 3 trial tests a drug called imetelstat against the best available treatments for people with advanced myelofibrosis whose disease has stopped responding to JAK inhibitors. The study includes 327 participants and aims to see if imetelstat can help them live longer and feel better. The drug is given intravenously every three weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
imetelstat
What this could lead to
If successful, imetelstat could offer a new treatment option that extends survival and reduces symptoms for people with advanced myelofibrosis who have stopped responding to current therapies.
What could go wrong
This is a late-stage trial, but the drug may still fail to improve survival or cause significant side effects. Results may not apply to all patients with myelofibrosis.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • A.O.di Bologna Policl.S.Orsola

    Bologna, Bologna, 40138, Italy

  • AOU Careggi

    Florence, Firenze, 50134, Italy

  • AOU Città della Salute e della Scienza di Torino

    Torino, Torino, 10126, Italy

  • AOU Federico II

    Naples, 80122, Italy

  • AOU San Luigi Gonzaga

    Orbassano, Torino, 10043, Italy

  • ASL Roma 2 - PO "S. Eugenio"

    Roma, 00144, Italy

  • ASST Grande Ospedale Metropoli

    Milan, 20162, Italy

  • AUSL di Rimini Ospedale Infermi di Rimini

    Rimini, Rimini, 47900, Italy

  • AZ Klina

    Antwerp, Antwerpen, 2930, Belgium

  • All India Institute of Medical Sciences

    Bhubaneswar, Odisha, 751019, India

  • All India Institute of Medical Sciences, Dept. of Hematology, New Delhi (All India Institute Of Medical Sciences)

    New Delhi, National Capital Territory of Delhi, 110029, India

  • Ankara University Medical Facu

    Ankara, Ankara, 6590, Turkey (Türkiye)

  • Arcispedale S Maria Nuova, AO di Reggio Emilia

    Reggio Calabria, Reggio Calabria, 42123, Italy

  • Arcispedale S.Anna - Ematologi

    Cona, Ferrara, 44124, Italy

  • Ars Medical Sp. z o.o.

    Piła, Greater Poland Voivodeship, 64-920, Poland

  • Assuta Ashdod University Hospi

    Ashdod, Southern District, 7747629, Israel

  • Azienda Ospedaliera Bianchi-Me

    Reggio Calabria, Reggio Calabria, 89124, Italy

  • Azienda Ospedaliera San Gerard

    Monza, 20900, Italy

  • BRCR Medical Center Inc

    Plantation, Florida, 33326, United States

  • Barzilai Medical Center

    Ashkelon, Southern District, 78278, Israel

  • Bnai Zion Medical Center

    Haifa, 31048, Israel

  • Budgetary Healthcare Institution of Omsk Region

    Omsk, 644013, Russia

  • CEPON Centro de Pesquisas Oncologicas SC

    Florianópolis, 88034-000, Brazil

  • CHRU Brest - Hôpital Morvan

    Brest, 29609, France

  • CHU - Hôpital Saint Louis - Centre D'Investigations Cliniq

    Paris, 75010, France

  • CHU Bretonneau

    Tours, Indre-et-Loire, 37044, France

  • CHU De Nantes - Hematologie

    Nantes, Loire-Atlantique, 44000, France

  • CHU de Nice - Hopital de l'Archet II - Pharmacie

    Nice, Nice Cedex 3, 06202, France

  • Carmel MC

    Haifa, 3436212, Israel

  • Centre Hospitalier Du Mans - Cancérologie Médicale

    Le Mans, Sarthe, 72037, France

  • Centre Hospitalier Lyon

    Pierre-Bénite, Auvergne-Rhône-Alpes, 69495, France

  • Centre Hospitalier de Jolimont

    Haine-Saint-Paul, Hainaut, 7100, Belgium

  • Centro Clinico Fundacao Champalimaud

    Lisbon, Lisbon District, 1400-038, Portugal

  • Centro Gaucho Integrado de Oncologia, Hematologia, Ensino e Pesquisa LTDA

    Porto Alegre, Rio Grande do Sul, 90470340, Brazil

  • Centro de oncologia Leonardo da Vinci

    Fortaleza, Ceará, 60135285, Brazil

  • Centrum Medyczne Pratia Poznan

    Skórzewo, Greater Poland Voivodeship, 60-185, Poland

  • Chang Gung Medical Foundation

    Chiayi City, Chiayi, 613, Taiwan

  • China Medical University Hospital - Hematology/Onc

    Taichung, 404, Taiwan

  • Clinica Ematologica, Univ. Deg

    Genova, Genova, 6- 16132, Italy

  • Deenanath Mangeshkar Hospital & Research Center

    Pune, 411004, India

  • Duke University Medical Center

    Durham, North Carolina, 27710, United States

  • Dél-pesti Centrumkórház Ország

    Budapest, H-1097, Hungary

  • Ege Universitesi Tip Fakultesi

    Izmir, İzmir, 35100, Turkey (Türkiye)

  • Epworth Healthcare

    Richmond, Victoria, 3121, Australia

  • Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico

    Milan, Milano, 20122, Italy

  • Fortis Hospital 154/9

    Bengaluru, Karnataka, 560076, India

  • Fortis Memorial Research Institute

    Gurgaon, New Delhi, 122002, India

  • Fundacao Doutor Amaral Carvalho / Hospital Amaral Carvalho

    São Paulo, São Paulo, 17210-120, Brazil

  • GOU VPO Saratov State Medical University n.a. V.I.

    Saratov, 410012, Russia

  • Gabrail Cancer Center

    Canton, Ohio, 44718, United States

  • Gazi University Medical Faculty

    Ankara, 06560, Turkey (Türkiye)

  • Guys and St Thomas' Hospital

    London, SE1 9RT, United Kingdom

  • H. Quirón Zaragoza

    Zaragoza, Zaragoza, 50012, Spain

  • H. San Pedro de Alcántara

    Cáceres, Cáceres, 10003, Spain

  • H.G.U. Alicante

    Alicante, Alicante, 03010, Spain

  • H.U. La Paz

    Madrid, Madrid, 28046, Spain

  • H.U.V. de la Victoria

    Málaga, Málaga, 29010, Spain

  • Hadassah Medical Organization

    Jerusalem, Jerusalem, 9112001, Israel

  • Hopital Bicetre

    Paris, Le Kremlin-Bicêtre, 94270, France

  • Hospital A.C.Camargo Cancer Center - Clinical Oncology

    São Paulo, Brazil

  • Hospital Aleman

    Ciudad de Buenos Aires, Buenos Aires, C118AAT, Argentina

  • Hospital Ampang

    Ampang, Selangor, 68000, Malaysia

  • Hospital Erasto Gaertner

    Curitiba, Paraná, 81520-060, Brazil

  • Hospital Israelita Albert Einstein

    São Paulo, São Paulo, 05651-901, Brazil

  • Hospital Pablo Tobon Uribe

    Antioquia, Colombia

  • Hospital Pulau Pinang

    Pulau Pinang, Georgetown, 10990, Malaysia

  • Hospital Raja Perempuan Zainab II

    Kota Bharu, Kelantan, 15586, Malaysia

  • Hospital Sultanah Aminah Johor Bahru

    Johor Bahru, Johor, 80000, Malaysia

  • Hospital U. 12 Octubre

    Madrid, Madrid, 28041, Spain

  • Hospital Universitario Virgen

    Granada, Granada, 18014, Spain

  • Hospital Universitario de Gran

    Las Palmas de Gran Canaria, Canary Islands, 35019, Spain

  • Hospital das Clínicas UFG

    Goiânia, Goiás, 74605, Brazil

  • Hospital de Clinicas de Porto Alegre - UFRGS

    Porto Alegre, Rio Grande do Sul, 90035-903, Brazil

  • Icahn School of Medicine at Mount Sinai

    New York, New York, 10029, United States

  • Inje University Busan Paik Hos

    Busan, Busan Gwang'Yeogsi [Pusan-Kwangyokshi], 47392, South Korea

  • Inje University Haeundae Paik Hospital

    Busan, Busan Gwang'Yeogsi [Pusan-Kwangyokshi], 48108, South Korea

  • Institut Català d'Oncologia-Ho

    Badalona, Barcelona, 08916, Spain

  • Irccs Irst

    Meldola, 47014, Italy

  • Istanbul üniversitesi cerrahpaşa

    Istanbul, Istanbul, 34098, Turkey (Türkiye)

  • J.S.C."K.Eristavi National Cen

    Tbilisi, K'alak'i T'bilisi, 0159, Georgia

  • Kaplan Medical Center

    Rehovot, Central District, 7610001, Israel

  • Kepler Universitätsklinikum Gm

    Linz, Upper Austria, 4021, Austria

  • Klinikum Wels-Grieskirchen GmbH

    Wels, Upper Austria, 4600, Austria

  • Krankenhaus Hietzing mit Neurologischem Zentrum Rosenhügel

    Wein, Burgenland, 1130, Austria

  • Krankenhaus der Elisabethinen

    Linz, Upper Austria, 4020, Austria

  • LTD Israeli-Georgian Medical R

    Tbilisi, 0112, Georgia

  • Ltd "Medinvest - Institute of Hematology and Trans

    Tbilisi, K'alak'i T'bilisi, 186, Georgia

  • M.Zodelava Hematology Center L

    Tbilisi, 0112, Georgia

  • MONIKI - Oncology

    Moscow, Moscow Oblast, 129110, Russia

  • MUZ City Clinical Hospital # 2

    Novosibirsk, Novosibirsk Oblast, 630091, Russia

  • Marmara university pendik training and research hospital

    Istanbul, Istanbul, 34899, Turkey (Türkiye)

  • Martin-Luther-Universität Halle-Wittenberg

    Halle, Saxony-Anhalt, 6120, Germany

  • Medical Park Mersin Hastanesi

    Mersin, Mersin, Turkey (Türkiye)

  • Medipol Bagcilar Mega Hospital

    Istanbul, Istanbul, 34214, Turkey (Türkiye)

  • Multi Profile Clinic Consilium

    Tbilisi, 0179, Georgia

  • National University Cancer Institute (NCIS)

    Singapore, Central Singapore, 119074, Singapore

  • Nilratan Sircar Medical College

    Kolkata, West Bengal, 700014, India

  • Nirmal Hospital - Hematology

    Surat, Gujarat, 395002, India

  • Northwest Medical Specialties PLLC

    Seattle, Washington, 98405, United States

  • Norton Cancer Institute

    Louisville, Kentucky, 40207, United States

  • Odense University Hospital - Hematology

    Odense, DK-5000 C, Denmark

  • Oncologos del Occidente S.A

    Pereira, Risaralda Department, 660000, Colombia

  • Ospedale Civile S.Maria delle Croci, AUSL Ravenna

    Ravenna, Ravenna, 48121, Italy

  • Ospedale S.Bortolo, AULSS n.6

    Vicenza, Vicenza, 36100, Italy

  • Ospedale di Circolo, PO Varese

    Varese, Varese, 21100, Italy

  • Oxford University Hospitals

    Oxford, OX3 9DS, United Kingdom

  • PO Civile SS.Antonio e Biagio

    Alessandria, Alessandria, 15121, Italy

  • Policlinico Universitario Agostino Gemelli

    Roma, Roma, 00168, Italy

  • Prairie Lakes Health Care System, Inc.

    Watertown, South Dakota, 57201, United States

  • Pratia Onkologia Katowice

    Katowice, Silesian Voivodeship, 40-519, Poland

  • Presidio Ospedaliero Garibaldi

    Catania, 95122, Italy

  • Royal Brisbane and Women's Hospital

    Herston, Queensland, 4011, Australia

  • Royal Hobart Hospital

    Hobart, Tasmania, 7000, Australia

  • Royal North Shore Hospital

    St Leonards, New South Wales, 2065, Australia

  • Sahyadri Specialty Hospital

    Pune, India

  • Sakarya Research and Training Hospital - Medical Oncology

    Adapazarı, 54100, Turkey (Türkiye)

  • Sanatorio Allende

    Córdoba, X5000JHQ, Argentina

  • Sanatorio de la Mujer

    Rosario, Santa Fe Province, S2000ORE, Argentina

  • Sarawak General Hospital

    Kuching, Sarawak, 93586, Malaysia

  • Seoul National University Hospital - Department of Internal

    Seoul, Seoul Teugbyeolsi [Seoul-T'Ukp, 03080, South Korea

  • Severance Hospital, Yonsei Uni

    Seoul, 3722, South Korea

  • Shamir Medical Center (Assaf Harofeh)

    Ẕerifin, Central District, 7030000, Israel

  • Singapore General Hospital

    Singapore, Central Singapore, 169608, Singapore

  • Sir Ganga Ram Hospital

    New Delhi, National Capital Territory of Delhi, 110060, India

  • Smilow Cancer Center at YNHH

    New Haven, Connecticut, 06511, United States

  • Soroka Medical Center - Hematology Institute

    Beersheba, 84101, Israel

  • Specialized Hospital for Active Therapy of Hematological dis

    Sofia, Sofia, 1756, Bulgaria

  • St Bartholomew's Hospital

    London, EC1A 7BE, United Kingdom

  • St. John's Medical College Hospital

    Bangalore, Karnataka, 560 034, India

  • Szabolcs-Szatmár-Bereg Megyei Önkormányzat Jósa András

    Nyíregyháza, 4400, Hungary

  • The Catholic University of Korea

    Seongdong, 6591, South Korea

  • The University of Texas MD

    Houston, Texas, 77030-4000, United States

  • UCLA David Geffen School of Medicine

    Los Angeles, California, 90096, United States

  • UMBAL Sveti Georgi

    Plovdiv, Plovdiv, 4002, Bulgaria

  • UZ Antwerpen

    Edegem, Antwerpen, 2650, Belgium

  • Universitair Ziekenhuis Brussel - Myeloom Centrum Brussel (MCB)

    Jette, Belgium

  • Universitair Ziekenhuis Gent

    Ghent, Oost-Vlaanderen, 9000, Belgium

  • University of California-San Diego/Moores UCSD Cancer Center

    La Jolla, California, 92093-1503, United States

  • University of South Florida

    Tampa, Florida, 33612, United States

  • Universitätsklinikum Carl Gust

    Dresden, Free and Hanseatic City of Hamburg, 1307, Germany

  • Universitätsklinikum Leipzig AöR

    Leipzig, Saxony, 04103, Germany

  • Universitätsklinikum Mannheim - University of Heidelberg

    Mannheim, Baden-Wurttemberg, 68167, Germany

  • Universitätsklinikum Tübingen

    Tübingen, Baden-Wurttemberg, 72076, Germany

  • Wojewodzki Szpital Specjalistyczny

    Biała Podlaska, 21-500, Poland

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