Genetically modified virus takes on tough melanoma

NCT ID NCT06264180

Recruiting now Disease control Sponsor: Replimune, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 16, 2026 · Updated 3 times

Summary

This Phase 3 trial tests whether a genetically modified herpes virus (vusolimogene oderparepvec) combined with the immunotherapy drug nivolumab can help people with advanced melanoma that has stopped responding to prior treatments. About 400 participants will receive either the virus-immunotherapy combo or a standard treatment chosen by their doctor. The main goal is to see if the combination helps people live longer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Vusolimogene oderparepvec (a genetically modified herpes virus) combined with nivolumab (an immunotherapy drug)
What this could lead to: If successful, this combination could offer a new treatment option for people with advanced melanoma that no longer responds to standard immunotherapies.
What could go wrong: This is a large Phase 3 trial, but the virus-based therapy is still experimental. It may not improve survival or could cause side effects like flu-like symptoms or injection-site reactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cutaneous melanoma melanoma metastatic melanoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED MELANOMA

Contacts and locations

Locations

Advocate Lutheran General Hospital
WITHDRAWN

Park Ridge, Illinois, 60068, United States
Banner MD Anderson Cancer Center
RECRUITING

Gilbert, Arizona, 85234, United States
Baptist MD Anderson Cancer Center
RECRUITING

Jacksonville, Florida, 32207, United States
CHU Nice
RECRUITING

Nice, 06200, France
CHU de Bordeaux, Hôpital Saint-André
RECRUITING

Bordeaux, 33075, France
CHU de Lille
RECRUITING

Lille, 59000, France
Charité - Universitätsmedizin Berlin
RECRUITING

Berlin, 10117, Germany
Clatterbridge Cancer Centre NHS Foundation Trust
RECRUITING

Liverpool, L7 8YA, United Kingdom
Clinica Universidad de Navarra - Madrid
RECRUITING

Madrid, 28027, Spain
Clinica Universidad de Navarra - Pamplona
RECRUITING

Pamplona, 31008, Spain
Corewell Health
RECRUITING

Grand Rapids, Michigan, 49503, United States
Dartmouth Hitchcock Cancer Center
RECRUITING

Lebanon, New Hampshire, 03756, United States
Duke Cancer Center
RECRUITING

Durham, North Carolina, 27710, United States
Fox Chase Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19111, United States
Guy's & St. Thomas' NHS Foundation Trust
RECRUITING

London, SE1 9RT, United Kingdom
Hackensack University Medical Center
RECRUITING

Hackensack, New Jersey, 07601, United States
Helios Klinik
RECRUITING

Erfurt, 99089, Germany
Henry Ford Cancer - Detroit (Brigitte Harris Cancer Pavilion)
WITHDRAWN

Detroit, Michigan, 48202, United States
Hopital de La Timone
RECRUITING

Marseille, 13005, France
Hospices Civils de Lyon (HCL) - Centre Hospitalier Lyon-Sud
RECRUITING

Pierre-Bénite, 69495, France
Hospital Clinic de Barcelona
RECRUITING

Barcelona, 08036, Spain
Hospital Clínico Universitario Virgen de la Arrixaca
RECRUITING

El Palmar, 30120, Spain
Hospital Universitari Vall d'Hebron
RECRUITING

Barcelona, 08035, Spain
Hospital Universitario 12 de Octubre
RECRUITING

Madrid, 28041, Spain
Huntsman Cancer Institute
RECRUITING

Salt Lake City, Utah, 84112, United States
Hôpital Saint Louis - AP-HP
RECRUITING

Paris, 75010, France
Institut Gustave Roussy
RECRUITING

Villejuif, 94800, France
Intermountain Health
RECRUITING

Murray, Utah, 84107, United States
LMU München - Klinik and Poliklinik für Dermatologie und Allergologie, Dermatoonkologie
RECRUITING

München, 80337, Germany
MD Anderson Cancer Center at Cooper
WITHDRAWN

Camden, New Jersey, 08103, United States
Maria Sklodowska-Curie National Research Institute of Oncology
RECRUITING

Warsaw, 02-781, Poland
MedStar Washington Hospital Center
RECRUITING

Washington D.C., District of Columbia, 20010, United States
Memorial Cancer Institute at Memorial Regional Hospital
RECRUITING

Hollywood, Florida, 33021, United States
Moffitt Cancer Center
RECRUITING

Tampa, Florida, 33612, United States
Montefiore Medical Center
RECRUITING

The Bronx, New York, 10461, United States
Morristown Medical Center - Atlantic Health System
RECRUITING

Morristown, New Jersey, 07960, United States
National and Kapodistrian University of Athens, General Hospital of Athens "Laiko"
RECRUITING

Athens, 11527, Greece
Northwell Health, R.J. Zuckerberg Cancer Center
RECRUITING

Lake Success, New York, 11042, United States
Northwestern Memorial Hospital
RECRUITING

Chicago, Illinois, 60611, United States
Rhode Island Hospital
RECRUITING

Providence, Rhode Island, 02903, United States
Roswell Park Cancer Institute
RECRUITING

Buffalo, New York, 14263, United States
Royal Free London NHS Foundation Trust - Royal Free Hospital
RECRUITING

London, NW3 2QG, United Kingdom
San Francisco Oncology Associates
RECRUITING

San Francisco, California, 94115, United States
St. George Regional Hospital
WITHDRAWN

St. George, Utah, 84790, United States
Stanford Cancer Institute
RECRUITING

Palo Alto, California, 94304, United States
Stony Brook University Cancer Center
WITHDRAWN

Stony Brook, New York, 11794, United States
Sutter Medical Group
WITHDRAWN

Sacramento, California, 95816, United States
Texas Oncology
RECRUITING

Dallas, Texas, 75246, United States
The Angeles Clinic and Research Institute
RECRUITING

Los Angeles, California, 90025, United States
The Christie NHS Foundation Trust
RECRUITING

Manchester, M20 4BX, United Kingdom
The Melanoma and Skin Cancer Institute
RECRUITING

Englewood, Colorado, 80113, United States
The Ohio State University- Martha Morehouse Tower
RECRUITING

Columbus, Ohio, 43210, United States
The Royal Marsden NHS Foundation Trust
RECRUITING

London, SW3 6JJ, United Kingdom
The University of Texas MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Thomas Jefferson University
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
UC Irvine Health, Chao Family Comprehensive Cancer Center
RECRUITING

Orange, California, 92868, United States
UC San Diego Moores Cancer Center
RECRUITING

La Jolla, California, 92037, United States
UCLA Department of Medicine - Hematology/Oncology
RECRUITING

Los Angeles, California, 90095, United States
UCSF Helen Diller Family Comprehensive Cancer Center
RECRUITING

San Francisco, California, 94143, United States
UPMC
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
USC Norris Comprehensive Cancer Center
RECRUITING

Los Angeles, California, 90033, United States
Universitatsklinikum Mainz Hautklinik und Poliklinik
RECRUITING

Mainz, 55131, Germany
University Hospital Carl Gustav Carus Dresden
RECRUITING

Dresden, 01307, Germany
University of Colorado Hospital - Anschutz Cancer Pavilion
RECRUITING

Aurora, Colorado, 80045, United States
University of Iowa
RECRUITING

Iowa City, Iowa, 52242, United States
University of Kansas Cancer Center
RECRUITING

Westwood, Kansas, 66205, United States
University of Kiel
RECRUITING

Kiel, 24105, Germany
University of Louisville Brown Cancer Center
RECRUITING

Louisville, Kentucky, 40202, United States
University of Minnesota
RECRUITING

Minneapolis, Minnesota, 55455, United States
University of North Carolina at Chapel Hill
RECRUITING

Chapel Hill, North Carolina, 27514, United States
University of Tennessee
RECRUITING

Knoxville, Tennessee, 37920, United States
University of Texas Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States
University of Vermont Medical Center
RECRUITING

Burlington, Vermont, 05401, United States
Universitätsklinikum Essen
RECRUITING

Essen, 45147, Germany
Universitätsklinikum Hospital Heidelberg
RECRUITING

Heidelberg, 69120, Germany
Universitätsklinikum Medical Center
RECRUITING

Hamburg, 20246, Germany
Universitätsklinikum of Tübingen
RECRUITING

Tübingen, 72076, Germany
Uniwersyteckie Centrum Kliniczne
RECRUITING

Gdansk, 80-214, Poland
West Cancer Center and Research Institute
RECRUITING

Germantown, Tennessee, 38138, United States
West Virginia University
RECRUITING

Morgantown, West Virginia, 26506, United States
Winship Cancer Institute, Emory University
RECRUITING

Atlanta, Georgia, 30322, United States

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