New radiation technique may spare bowel in cervical cancer treatment
NCT ID NCT01279135
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 3 trial tested whether a newer, more precise type of radiation (image-guided intensity modulated radiotherapy) could reduce long-term bowel problems compared to standard radiation in 300 women who had surgery for cervical cancer. The study focused on lowering severe bowel side effects that can occur months or years after treatment. Results could help doctors choose the best radiation approach to improve quality of life.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Radiation therapy (image-guided intensity modulated radiotherapy vs conventional radiotherapy)
- What this could lead to
- If successful, this could establish a new standard of care that reduces long-term bowel damage for women receiving radiation after cervical cancer surgery.
- What could go wrong
- This trial is completed, but results may not apply to all patients or settings. The benefit may be modest, and some side effects may still occur.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
-
300 people
The number who actually took part.
- Started
-
Jan 2011
- Finished
-
May 2020
- Lead sponsor
-
A government agency
The lead sponsor is a government body.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 years and older
- Sex
-
Female participants only
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Histopathological diagnosis of carcinoma cervix with postoperative intermediate or high risk features. * Age \>18 years. * Planned for Wertheim's hysterectomy or has already undergone Wertheim's hysterectomy OR has undergone Simple Hysterectomy with no evidence of residual nodes on MRI/PET imaging+/- confirmatory nodal biopsy. * No evidence of paraaortic nodal metastasis. Exclusion Criteria: * History of multiple previous abdominal surgeries placing patient at baseline high risk of bowel toxicity or any other medical condition with baseline bowel movement disorder. * Rectal Polyps or extensive hemorrhoids.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Cancer cervix are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre
Navi Mumbai, Maharashtra, 410210, India
More trials for these conditions
Other studies related to the condition(s) this trial covers.