New drug shows promise for Hard-to-Treat cancers with specific gene changes

NCT ID NCT04174716

First seen Apr 21, 2026 · Last updated May 12, 2026 · Updated 5 times

Summary

This study tested an experimental drug called IDX-1197 in 108 adults with solid tumors that have a specific gene mutation (HRR). Participants had already tried standard treatments without success. The goal was to find the safest and most effective dose and see if the drug could shrink tumors.

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Contacts and locations

Locations

  • Ajou University Hospital

    Suwon, Gyeonggi-do, 16499, South Korea

  • Asan Medical Center

    Seoul, 05505, South Korea

  • Cha University Bundang Medical Center

    Seongnam-si, 13496, South Korea

  • Chonnam National University Hwasun Hospital

    Hwasun, Jeollanam-do, 58128, South Korea

  • Dong-a University Hospital

    Busan, 49201, South Korea

  • Gachon University Gil Medical Center

    Incheon, 21565, South Korea

  • Gyeongsang National University Hospital

    Jinju, Gyeongsangnam-do, 52727, South Korea

  • Inje University Haeundae Hospital

    Busan, 48108, South Korea

  • Kangbuk Samsung Hospital

    Seoul, 03181, South Korea

  • Korea University Anam Hospital

    Seoul, 02841, South Korea

  • Korea University Guro Hospital

    Seoul, 08308, South Korea

  • National Cancer Centre

    Goyang, Gyeongggi-do, 10408, South Korea

  • Pusan National University Yangsan Hospital

    Busan, 50612, South Korea

  • Samsung Medical Center

    Seoul, 06351, South Korea

  • Seoul Metropolitan Government Seoul National University Boramae Medical Center

    Seoul, 07061, South Korea

  • Seoul National University Bundang Hospital

    Seongnam-si, Gyeonggi-do, 13620, South Korea

  • Seoul National University Hospital

    Seoul, 03080, South Korea

  • Severance Hospital, Yonsei University Health System

    Seoul, 03722, South Korea

  • The Catholic University of Korea, Seoul St. Mary's Hospital

    Seoul, 06591, South Korea

Conditions

Explore the condition pages connected to this study.