Study of therapeutic plasma exchange, rituximab and intravenous immunoglobulin for acute exacerbations of idiopathic pulmonary fibrosis (STRIVE-IPF)
NCT ID NCT03286556
Summary
Acute exacerbations (AE) are a dreaded manifestation of idiopathic pulmonary fibrosis (IPF) that presents with rapidly worsening respiratory function over days to weeks. AE account for about 1/2 the deaths in IPF patients, and are refractory to all medical therapies attempted to date. Considerable preliminary data shows pathological B-cell abnormalities and autoantibodies are present in AE-IPF and associated with disease severity. The experimental therapy here (therapeutic plasma exchange plus rituximab plus intravenous immunoglobulin) is mechanistically targeted to ameliorate autoantibody-mediated pulmonary injury. Anecdotal pilot studies indicate these treatments have significant benefit for a disease syndrome that has, until now, been almost invariably inexorable. This clinical trial has the potential to profoundly affect current paradigms and treatment approaches to patients with AE-IPF.
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Contacts and locations
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Locations
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Baylor University Medical Center
Houston, Texas, 77030, United States
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Dan Dilling
Chicago, Illinois, 60611, United States
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Temple University Hospital
Philadelphia, Pennsylvania, 19140, United States
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Thomas Jefferson University Medical Center
Philadelphia, Pennsylvania, 19107, United States
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University of Alabama at Birmingham
Birmingham, Alabama, 35233, United States
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University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, 15213, United States
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University of Utah Medical Center
Salt Lake City, Utah, 84112, United States
Conditions
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