New drug combo aims to boost stem cell transplant success against tough lymphoma

NCT ID NCT02443077

Ongoing Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

Summary

This study is testing whether adding the drug ibrutinib to a stem cell transplant helps patients with a specific aggressive lymphoma that has returned or not responded to prior treatment. Patients receive either ibrutinib or a placebo (inactive pill) before and for a year after their transplant. The main goal is to see if the drug helps keep the cancer from returning for a longer period after the transplant.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Locations

Alaska Breast Care and Surgery LLC

Anchorage, Alaska, 99508, United States
Alaska Oncology and Hematology LLC

Anchorage, Alaska, 99508, United States
Alaska Women's Cancer Care

Anchorage, Alaska, 99508, United States
American Fork Hospital / Huntsman Intermountain Cancer Center

American Fork, Utah, 84003, United States
Anchorage Associates in Radiation Medicine

Anchorage, Alaska, 98508, United States
Anchorage Oncology Centre

Anchorage, Alaska, 99508, United States
Anchorage Radiation Therapy Center

Anchorage, Alaska, 99504, United States
Ascension Via Christi Hospitals Wichita

Wichita, Kansas, 67214, United States
Associates In Womens Health

Wichita, Kansas, 67208, United States
Augusta University Medical Center

Augusta, Georgia, 30912, United States
Aurora Bay Area Medical Group-Marinette

Marinette, Wisconsin, 54143, United States
Aurora BayCare Medical Center

Green Bay, Wisconsin, 54311, United States
Aurora Cancer Care-Grafton

Grafton, Wisconsin, 53024, United States
Aurora Cancer Care-Kenosha South

Kenosha, Wisconsin, 53142, United States
Aurora Cancer Care-Milwaukee

Milwaukee, Wisconsin, 53209, United States
Aurora Cancer Care-Milwaukee West

Wauwatosa, Wisconsin, 53226, United States
Aurora Cancer Care-Racine

Racine, Wisconsin, 53406, United States
Aurora Cancer Care-Southern Lakes VLCC

Burlington, Wisconsin, 53105, United States
Aurora Health Care Germantown Health Center

Germantown, Wisconsin, 53022, United States
Aurora Health Center-Fond du Lac

Fond du Lac, Wisconsin, 54937, United States
Aurora Medical Center in Summit

Summit, Wisconsin, 53066, United States
Aurora Saint Luke's Medical Center

Milwaukee, Wisconsin, 53215, United States
Aurora Sinai Medical Center

Milwaukee, Wisconsin, 53233, United States
Aurora West Allis Medical Center

West Allis, Wisconsin, 53227, United States
Avera Cancer Institute

Sioux Falls, South Dakota, 57105, United States
Banner North Colorado Medical Center

Greeley, Colorado, 80631, United States
Banner North Colorado Medical Center - Loveland Campus

Loveland, Colorado, 80539, United States
Banner University Medical Center - Tucson

Tucson, Arizona, 85719, United States
Baptist Memorial Hospital and Cancer Center-Memphis

Memphis, Tennessee, 38120, United States
Baton Rouge General Medical Center

Baton Rouge, Louisiana, 70806, United States
Bay Area Hospital

Coos Bay, Oregon, 97420, United States
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

Houston, Texas, 77030, United States
Beacon Kalamazoo

Kalamazoo, Michigan, 49048, United States
Beacon Kalamazoo Cancer Center

Kalamazoo, Michigan, 49009, United States
Beebe Health Campus

Rehoboth Beach, Delaware, 19971, United States
Beebe Medical Center

Lewes, Delaware, 19958, United States
Benefis Sletten Cancer Institute

Great Falls, Montana, 59405, United States
Billings Clinic Cancer Center

Billings, Montana, 59101, United States
Billings Clinic-Cody

Cody, Wyoming, 82414, United States
Boulder Community Foothills Hospital

Boulder, Colorado, 80303, United States
Bozeman Health Deaconess Hospital

Bozeman, Montana, 59715, United States
Bronson Battle Creek

Battle Creek, Michigan, 49017, United States
Bronson Methodist Hospital

Kalamazoo, Michigan, 49007, United States
Cancer Care Center at Island Hospital

Anacortes, Washington, 98221, United States
Cancer Center of Kansas - Chanute

Chanute, Kansas, 66720, United States
Cancer Center of Kansas - Dodge City

Dodge City, Kansas, 67801, United States
Cancer Center of Kansas - El Dorado

El Dorado, Kansas, 67042, United States
Cancer Center of Kansas - Fort Scott

Fort Scott, Kansas, 66701, United States
Cancer Center of Kansas - McPherson

McPherson, Kansas, 67460, United States
Cancer Center of Kansas - Newton

Newton, Kansas, 67114, United States
Cancer Center of Kansas - Parsons

Parsons, Kansas, 67357, United States
Cancer Center of Kansas - Pratt

Pratt, Kansas, 67124, United States
Cancer Center of Kansas - Salina

Salina, Kansas, 67401, United States
Cancer Center of Kansas - Wellington

Wellington, Kansas, 67152, United States
Cancer Center of Kansas - Wichita

Wichita, Kansas, 67214, United States
Cancer Center of Kansas - Winfield

Winfield, Kansas, 67156, United States
Cancer Center of Kansas-Independence

Independence, Kansas, 67301, United States
Cancer Center of Kansas-Kingman

Kingman, Kansas, 67068, United States
Cancer Center of Kansas-Liberal

Liberal, Kansas, 67905, United States
Cancer Center of Kansas-Manhattan

Manhattan, Kansas, 66502, United States
Cancer Center of Kansas-Wichita Medical Arts Tower

Wichita, Kansas, 67208, United States
Cancer and Hematology Centers of Western Michigan - Norton Shores

Norton Shores, Michigan, 49444, United States
Case Western Reserve University

Cleveland, Ohio, 44106, United States
Cedars Sinai Medical Center

Los Angeles, California, 90048, United States
Cheyenne Regional Medical Center-West

Cheyenne, Wyoming, 82001, United States
Children's Hospital at Montefiore

The Bronx, New York, 10467, United States
Christiana Care Health System-Christiana Hospital

Newark, Delaware, 19718, United States
Christiana Care Health System-Concord Health Center

Chadds Ford, Pennsylvania, 19317, United States
Christiana Care Health System-Wilmington Hospital

Wilmington, Delaware, 19801, United States
City of Hope Comprehensive Cancer Center

Duarte, California, 91010, United States
Clackamas Radiation Oncology Center

Clackamas, Oregon, 97015, United States
Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States
Colorado Blood Cancer Institute

Denver, Colorado, 80218, United States
Community Hospital of Anaconda

Anaconda, Montana, 59711, United States
Community Medical Center

Missoula, Montana, 59804, United States
Community Medical Center

Scranton, Pennsylvania, 18510, United States
Corewell Health Grand Rapids Hospitals - Butterworth Hospital

Grand Rapids, Michigan, 49503, United States
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center

Saint Joseph, Michigan, 49085, United States
Corewell Health Lakeland Hospitals - Niles Hospital

Niles, Michigan, 49120, United States
Corewell Health Lakeland Hospitals - Saint Joseph Hospital

Saint Joseph, Michigan, 49085, United States
Corewell Health Reed City Hospital

Reed City, Michigan, 49677, United States
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

Lebanon, New Hampshire, 03756, United States
Delaware Clinical and Laboratory Physicians PA

Newark, Delaware, 19713, United States
Denver Health Medical Center

Denver, Colorado, 80204, United States
Duke University Medical Center

Durham, North Carolina, 27710, United States
Emory University Hospital/Winship Cancer Institute

Atlanta, Georgia, 30322, United States
Fairbanks Memorial Hospital

Fairbanks, Alaska, 99701, United States
Farmington Health Center

Farmington, Utah, 84025, United States
Fox Chase Cancer Center

Philadelphia, Pennsylvania, 19111, United States
Fred Hutchinson Cancer Center

Seattle, Washington, 98109, United States
Geisinger Cancer Services-Pottsville

Pottsville, Pennsylvania, 17901, United States
Geisinger Medical Center

Danville, Pennsylvania, 17822, United States
Geisinger Medical Center-Cancer Center Hazleton

Hazleton, Pennsylvania, 18201, United States
Geisinger Medical Group

State College, Pennsylvania, 16801, United States
Geisinger Medical Oncology-Lewisburg

Lewisburg, Pennsylvania, 17837, United States
Geisinger Medical Oncology-Selinsgrove

Selinsgrove, Pennsylvania, 17870, United States
Geisinger Wyoming Valley/Henry Cancer Center

Wilkes-Barre, Pennsylvania, 18711, United States
Good Samaritan Hospital - Cancer Centers of Colorado

Lafayette, Colorado, 80026, United States
Grand Valley Oncology

Grand Junction, Colorado, 81505, United States
Great Falls Clinic

Great Falls, Montana, 59405, United States
Helen F Graham Cancer Center

Newark, Delaware, 19713, United States
Hematology/Oncology Clinic PLLC

Baton Rouge, Louisiana, 70809, United States
Huntsman Cancer Institute/University of Utah

Salt Lake City, Utah, 84112, United States
Intermountain Health Lutheran Hospital

Wheat Ridge, Colorado, 80401, United States
Intermountain Medical Center

Murray, Utah, 84107, United States
Johns Hopkins University/Sidney Kimmel Cancer Center

Baltimore, Maryland, 21287, United States
Kadlec Clinic Hematology and Oncology

Kennewick, Washington, 99336, United States
Kaiser Permanente Washington

Seattle, Washington, 98112, United States
Katmai Oncology Group

Anchorage, Alaska, 99508, United States
King Faisal Specialist Hospital and Research Centre

Riyadh, 11211, Saudi Arabia
Kootenai Clinic Cancer Services - Post Falls

Post Falls, Idaho, 83854, United States
Kootenai Clinic Cancer Services - Sandpoint

Sandpoint, Idaho, 83864, United States
Kootenai Health - Coeur d'Alene

Coeur d'Alene, Idaho, 83814, United States
LDS Hospital

Salt Lake City, Utah, 84143, United States
LSU Health Sciences Center at Shreveport

Shreveport, Louisiana, 71103, United States
Lawrence Memorial Hospital

Lawrence, Kansas, 66044, United States
Legacy Good Samaritan Hospital and Medical Center

Portland, Oregon, 97210, United States
Lewistown Hospital

Lewistown, Pennsylvania, 17044, United States
Logan Health Medical Center

Kalispell, Montana, 59901, United States
Logan Regional Hospital

Logan, Utah, 84321, United States
Loma Linda University Medical Center

Loma Linda, California, 92354, United States
Loyola University Medical Center

Maywood, Illinois, 60153, United States
Marshfield Clinic - Wisconsin Rapids Center

Wisconsin Rapids, Wisconsin, 54494, United States
Marshfield Clinic Cancer Center at Sacred Heart

Eau Claire, Wisconsin, 54701, United States
Marshfield Clinic-Chippewa Center

Chippewa Falls, Wisconsin, 54729, United States
Marshfield Clinic-Wausau Center

Wausau, Wisconsin, 54401, United States
Marshfield Medical Center

Marshfield, Wisconsin, 54449, United States
Marshfield Medical Center - Ladysmith

Ladysmith, Wisconsin, 54848, United States
Marshfield Medical Center - Minocqua

Minocqua, Wisconsin, 54548, United States
Marshfield Medical Center - Weston

Weston, Wisconsin, 54476, United States
Marshfield Medical Center-EC Cancer Center

Eau Claire, Wisconsin, 54701, United States
Marshfield Medical Center-Marshfield

Marshfield, Wisconsin, 54449, United States
Marshfield Medical Center-Rice Lake

Rice Lake, Wisconsin, 54868, United States
Marshfield Medical Center-River Region at Stevens Point

Stevens Point, Wisconsin, 54482, United States
Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States
McKay-Dee Hospital Center

Ogden, Utah, 84403, United States
Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Medical Oncology Hematology Consultants PA

Newark, Delaware, 19713, United States
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
Moffitt Cancer Center

Tampa, Florida, 33612, United States
Montefiore Medical Center - Moses Campus

The Bronx, New York, 10467, United States
Montefiore Medical Center-Einstein Campus

The Bronx, New York, 10461, United States
Montefiore Medical Center-Weiler Hospital

The Bronx, New York, 10461, United States
Mountain Blue Cancer Care Center - Swedish

Englewood, Colorado, 80113, United States
MultiCare Deaconess Cancer and Blood Specialty Center - Downtown

Spokane, Washington, 99204, United States
MultiCare Deaconess Cancer and Blood Specialty Center - North

Spokane, Washington, 99218, United States
MultiCare Deaconess Cancer and Blood Specialty Center - Valley

Spokane Valley, Washington, 99216, United States
Munson Medical Center

Traverse City, Michigan, 49684, United States
NYP/Weill Cornell Medical Center

New York, New York, 10065, United States
National Jewish Health-Main Campus

Denver, Colorado, 80206, United States
National Jewish Health-Western Hematology Oncology

Golden, Colorado, 80401, United States
Nebraska Medicine-Bellevue

Bellevue, Nebraska, 68123, United States
Nebraska Medicine-Village Pointe

Omaha, Nebraska, 68118, United States
Northside Hospital

Atlanta, Georgia, 30342, United States
Northwestern University

Chicago, Illinois, 60611, United States
Ochsner Medical Center Jefferson

New Orleans, Louisiana, 70121, United States
Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210, United States
Oregon Health and Science University

Portland, Oregon, 97239, United States
Pacific Gynecology Specialists

Seattle, Washington, 98104, United States
PeaceHealth Saint John Medical Center

Longview, Washington, 98632, United States
PeaceHealth Saint Joseph Medical Center

Bellingham, Washington, 98225, United States
PeaceHealth Southwest Medical Center

Vancouver, Washington, 98664, United States
Poudre Valley Hospital

Fort Collins, Colorado, 80524, United States
Presbyterian - Saint Lukes Medical Center - Health One

Denver, Colorado, 80218, United States
Prisma Health Cancer Institute - Butternut

Greenville, South Carolina, 29605, United States
Prisma Health Cancer Institute - Easley

Easley, South Carolina, 29640, United States
Prisma Health Cancer Institute - Eastside

Greenville, South Carolina, 29615, United States
Prisma Health Cancer Institute - Faris

Greenville, South Carolina, 29605, United States
Prisma Health Cancer Institute - Greer

Greer, South Carolina, 29650, United States
Prisma Health Cancer Institute - Laurens

Clinton, South Carolina, 29325, United States
Prisma Health Cancer Institute - Seneca

Seneca, South Carolina, 29672, United States
Prisma Health Cancer Institute - Spartanburg

Boiling Springs, South Carolina, 29316, United States
Prisma Health Greenville Memorial Hospital

Greenville, South Carolina, 29605, United States
Providence Alaska Medical Center

Anchorage, Alaska, 99508, United States
Providence Cancer Institute Clackamas Clinic

Clackamas, Oregon, 97015, United States
Providence Newberg Medical Center

Newberg, Oregon, 97132, United States
Providence Portland Medical Center

Portland, Oregon, 97213, United States
Providence Regional Cancer Partnership

Everett, Washington, 98201, United States
Providence Regional Cancer System-Aberdeen

Aberdeen, Washington, 98520, United States
Providence Regional Cancer System-Centralia

Centralia, Washington, 98531, United States
Providence Regional Cancer System-Lacey

Lacey, Washington, 98503, United States
Providence Regional Cancer System-Shelton

Shelton, Washington, 98584, United States
Providence Regional Cancer System-Yelm

Yelm, Washington, 98597, United States
Providence Saint Joseph Medical Center/Disney Family Cancer Center

Burbank, California, 91505, United States
Providence Saint Mary Regional Cancer Center

Walla Walla, Washington, 99362, United States
Providence Saint Vincent Medical Center

Portland, Oregon, 97225, United States
Providence Willamette Falls Medical Center

Oregon City, Oregon, 97045, United States
Riverton Hospital

Riverton, Utah, 84065, United States
Rocky Mountain Cancer Centers-Aurora

Aurora, Colorado, 80012, United States
Rocky Mountain Cancer Centers-Boulder

Boulder, Colorado, 80304, United States
Rocky Mountain Cancer Centers-Littleton

Littleton, Colorado, 80120, United States
Rocky Mountain Cancer Centers-Midtown

Denver, Colorado, 80218, United States
Rocky Mountain Cancer Centers-Rose

Denver, Colorado, 80220, United States
Rocky Mountain Cancer Centers-Sky Ridge

Lone Tree, Colorado, 80124, United States
Roswell Park Cancer Institute

Buffalo, New York, 14263, United States
Rush MD Anderson Cancer Center

Chicago, Illinois, 60612, United States
SSM Health Saint Louis University Hospital

St Louis, Missouri, 63104, United States
Saint Alphonsus Cancer Care Center-Boise

Boise, Idaho, 83706, United States
Saint Alphonsus Cancer Care Center-Caldwell

Caldwell, Idaho, 83605, United States
Saint Alphonsus Cancer Care Center-Nampa

Nampa, Idaho, 83687, United States
Saint Alphonsus Cancer Care Center-Ontario

Ontario, Oregon, 97914, United States
Saint Charles Health System

Bend, Oregon, 97701, United States
Saint Francis Cancer Center

Greenville, South Carolina, 29607, United States
Saint Francis Hospital

Greenville, South Carolina, 29601, United States
Saint George Regional Medical Center

St. George, Utah, 84770, United States
Saint Joseph Hospital - Cancer Centers of Colorado

Denver, Colorado, 80218, United States
Saint Luke's Cancer Institute - Boise

Boise, Idaho, 83712, United States
Saint Luke's Cancer Institute - Fruitland

Fruitland, Idaho, 83619, United States
Saint Luke's Cancer Institute - Meridian

Meridian, Idaho, 83642, United States
Saint Luke's Cancer Institute - Nampa

Nampa, Idaho, 83687, United States
Saint Luke's Cancer Institute - Twin Falls

Twin Falls, Idaho, 83301, United States
Saint Mary's Hospital and Regional Medical Center

Grand Junction, Colorado, 81501, United States
Saint Patrick Hospital - Community Hospital

Missoula, Montana, 59802, United States
Saint Peter's Community Hospital

Helena, Montana, 59601, United States
Saint Vincent Frontier Cancer Center

Billings, Montana, 59102, United States
Saint Vincent Healthcare

Billings, Montana, 59101, United States
Sandra L Maxwell Cancer Center

Cedar City, Utah, 84720, United States
Simonds-Sinon Regional Cancer Center

Fitchburg, Massachusetts, 01420, United States
Siteman Cancer Center at West County Hospital

Creve Coeur, Missouri, 63141, United States
Siteman Cancer Center-South County

St Louis, Missouri, 63129, United States
Smilow Cancer Center/Yale-New Haven Hospital

New Haven, Connecticut, 06510, United States
South Jordan Health Center

South Jordan, Utah, 84009, United States
State University of New York Upstate Medical University

Syracuse, New York, 13210, United States
Swedish Cancer Institute-Edmonds

Edmonds, Washington, 98026, United States
Swedish Cancer Institute-Issaquah

Issaquah, Washington, 98029, United States
Swedish Medical Center

Englewood, Colorado, 80113, United States
Swedish Medical Center-Ballard Campus

Seattle, Washington, 98107, United States
Swedish Medical Center-Cherry Hill

Seattle, Washington, 98122-5711, United States
Swedish Medical Center-First Hill

Seattle, Washington, 98122, United States
The James Graham Brown Cancer Center at University of Louisville

Louisville, Kentucky, 40202, United States
The Medical Center of Aurora

Aurora, Colorado, 80012, United States
The Women's Imaging Center

Denver, Colorado, 80209, United States
TidalHealth Nanticoke / Allen Cancer Center

Seaford, Delaware, 19973, United States
Trinity Health Grand Rapids Hospital

Grand Rapids, Michigan, 49503, United States
Trinity Health Muskegon Hospital

Muskegon, Michigan, 49444, United States
Tulane University School of Medicine

New Orleans, Louisiana, 70112, United States
UC Comprehensive Cancer Center at Silver Cross

New Lenox, Illinois, 60451, United States
UC Irvine Health/Chao Family Comprehensive Cancer Center

Orange, California, 92868, United States
UC San Diego Moores Cancer Center

La Jolla, California, 92093, United States
UCHealth Memorial Hospital Central

Colorado Springs, Colorado, 80909, United States
UCHealth University of Colorado Hospital

Aurora, Colorado, 80045, United States
UCSF Medical Center-Parnassus

San Francisco, California, 94143, United States
UF Health Cancer Institute - Gainesville

Gainesville, Florida, 32610, United States
UM Sylvester Comprehensive Cancer Center at Deerfield Beach

Deerfield Beach, Florida, 33442, United States
UM Sylvester Comprehensive Cancer Center at Plantation

Plantation, Florida, 33324, United States
UMass Memorial Medical Center - University Campus

Worcester, Massachusetts, 01655, United States
UNC Lineberger Comprehensive Cancer Center

Chapel Hill, North Carolina, 27599, United States
University of Arizona Cancer Center-North Campus

Tucson, Arizona, 85719, United States
University of California Davis Comprehensive Cancer Center

Sacramento, California, 95817, United States
University of Chicago Comprehensive Cancer Center

Chicago, Illinois, 60637, United States
University of Cincinnati Cancer Center-UC Medical Center

Cincinnati, Ohio, 45219, United States
University of Cincinnati Cancer Center-West Chester

West Chester, Ohio, 45069, United States
University of Illinois

Chicago, Illinois, 60612, United States
University of Kansas Cancer Center

Kansas City, Kansas, 66160, United States
University of Kansas Hospital-Westwood Cancer Center

Westwood, Kansas, 66205, United States
University of Miami Miller School of Medicine-Sylvester Cancer Center

Miami, Florida, 33136, United States
University of Michigan Health - West

Wyoming, Michigan, 49519, United States
University of Michigan Rogel Cancer Center

Ann Arbor, Michigan, 48109, United States
University of Minnesota/Masonic Cancer Center

Minneapolis, Minnesota, 55455, United States
University of Nebraska Medical Center

Omaha, Nebraska, 68198, United States
University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104, United States
University of Pittsburgh Cancer Institute (UPCI)

Pittsburgh, Pennsylvania, 15232, United States
University of Rochester

Rochester, New York, 14642, United States
University of Virginia Cancer Center

Charlottesville, Virginia, 22908, United States
University of Washington Medical Center - Montlake

Seattle, Washington, 98195, United States
University of Wisconsin Carbone Cancer Center - University Hospital

Madison, Wisconsin, 53792, United States
Upstate Cancer Center at Oswego

Oswego, New York, 13126, United States
Utah Cancer Specialists-Salt Lake City

Salt Lake City, Utah, 84106, United States
Utah Valley Regional Medical Center

Provo, Utah, 84604, United States
VCU Massey Comprehensive Cancer Center

Richmond, Virginia, 23298, United States
Vanderbilt Breast Center at One Hundred Oaks

Nashville, Tennessee, 37204, United States
Vanderbilt University/Ingram Cancer Center

Nashville, Tennessee, 37232, United States
Vanderbilt-Ingram Cancer Center Cool Springs

Franklin, Tennessee, 37067, United States
Vince Lombardi Cancer Clinic - Oshkosh

Oshkosh, Wisconsin, 54904, United States
Vince Lombardi Cancer Clinic-Sheboygan

Sheboygan, Wisconsin, 53081, United States
Vince Lombardi Cancer Clinic-Two Rivers

Two Rivers, Wisconsin, 54241, United States
Wake Forest University Health Sciences

Winston-Salem, North Carolina, 27157, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States
Wayne State University/Karmanos Cancer Institute

Detroit, Michigan, 48201, United States
West Michigan Cancer Center

Kalamazoo, Michigan, 49007, United States
Yale University

New Haven, Connecticut, 06520, United States

Conditions

Explore the condition pages connected to this study.

RECURRENT DIFFUSE LARGE B-CELL LYMPHOMA ACTIVATED B-CELL TYPE REFRACTORY DIFFUSE LARGE B-CELL LYMPHOMA ACTIVATED B-CELL TYPE