New hope for kids battling transplant complications

NCT ID NCT03790332

Completed Disease control Sponsor: Pharmacyclics LLC. Source: ClinicalTrials.gov ↗

Summary

This study aimed to find a safe and effective dose of the drug ibrutinib for children and young adults with chronic graft-versus-host disease (cGVHD), a serious complication that can occur after a stem cell transplant. It involved 59 participants aged 1 to 22 years who had moderate to severe cGVHD that did not fully respond to prior treatments. The main goals were to understand how the drug behaves in the body and to check its safety and side effects.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Ann & Robert H Lurie Children's Hospital of Chicago

Chicago, Illinois, 60611, United States
Asan Medical Center

Seoul, 05505, South Korea
CHU Nantes - Hopital Enfant Adolescent

Nantes, 44093, France
CHU Sainte-Justine

Montreal, Quebec, H3T1C5, Canada
Cancer Center for Children. The Children's Hospital at Westmead

Westmead, New South Wales, 2145, Australia
Charite-Universitaetsmedizin Berlin

Berlin, 13353, Germany
Children's Hospital

Aurora, Colorado, 80045, United States
Children's National Medical Center

Washington D.C., District of Columbia, 20010, United States
Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, 45229, United States
City of Hope

Duarte, California, 91010, United States
Dana-Farber Cancer Institute

Boston, Massachusetts, 02215, United States
Dipartimento di Onco-Ematologia e Terapia Cellulare e Genica

Roma, 00165, Italy
Federal State Budgetary Educational Institution of Higher Professional Education "LP.Pavlov First Saint Petersburg State Medical

Saint Petersburg, 197022, Russia
Federal State Budgetary Institution "Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology

Moscow, 117997, Russia
Fondazione MBBM-Clinica Pediatrica

Monza, 20900, Italy
Fred Hutchinson Cancer Research Center

Seattle, Washington, 98109, United States
Hackensack University Medical Center

Hackensack, New Jersey, 07601, United States
Hadassah Medical Centre

Jerusalem, 9112001, Israel
Hospital Infantil Universitario Nino Jesus

Madrid, 28009, Spain
Hospital Universitario Universitario La Paz

Madrid, 28046, Spain
Hospital Universitario Vall d'Hebron

Barcelona, 08035, Spain
Hôpital Robert-Debré Ap-Hp

Paris, 75019, France
Johns Hopkins All Children's Hospital

St. Petersburg, Florida, 33701, United States
Johns Hopkins University

Baltimore, Maryland, 21287, United States
Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Oregon Health and Science University

Portland, Oregon, 97239, United States
Primary Children's Hospital

Salt Lake City, Utah, 84113, United States
Princess Maxima Center

Utrecht, 3584 CS, Netherlands
Queensland Children's Hospital

South Brisbane, Queensland, 4101, Australia
Rady Children's Hospital

San Diego, California, 92123, United States
S.C. Farmacia Pediatrica - Presidio Ospedaliero Infantile Regina Margherita

Turin, 10126, Italy
Safari Day Care, Great Ormond Street Hospital

London, Greater London, WC1N 3JH, United Kingdom
Samsung Medical Center

Seoul, 06351, South Korea
Schneider Children's Medical Center in Israel

Petah Tikva, 4920235, Israel
Seoul National University Hospital

Seoul, 03080, South Korea
Seoul Saint Mary's Hospital

Seoul, 06591, South Korea
St. Anna Kinderspital

Vienna, 1090, Austria
St. Jude Children's Research Hospital

Memphis, Tennessee, 38105-2729, United States
Sydney Children's Hospital

Randwick, 2031, Australia
The Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, 19104, United States
The Edmond and Lily Safra Children's Hospital

Ramat Gan, 5262100, Israel
The Royal Children's Hospital

Parkville, Victoria, 3052, Australia
U.O.C. Ematologia Oncoematologia Pediatrica

Pavia, PV, 27100, Italy
University of California

San Francisco, California, 94158, United States
University of Minnesota Masonic Children's Hospital

Minneapolis, Minnesota, 55454, United States
Washington University

St Louis, Missouri, 63110, United States
children's and Women's Health Centre of British Columbia

Vancouver, British Columbia, V6H 3V4, Canada

Conditions

Explore the condition pages connected to this study.

CHRONIC GRAFT VERSUS HOST DISEASE