New Four-Drug cocktail aims to crush resistant myeloma
NCT ID NCT05896228
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial is testing whether a combination of four drugs—iberdomide, daratumumab, carfilzomib, and dexamethasone—can shrink or prevent the return of multiple myeloma in patients whose cancer has relapsed or stopped responding to prior treatments. About 30 participants will receive the therapy in cycles, and researchers will measure how many achieve a very low level of cancer cells (MRD-negativity) after eight cycles. The study also tracks side effects to see if the combination is safe and tolerable.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
iberdomide, daratumumab, carfilzomib, and dexamethasone
What this could lead to
If successful, this combination could offer a new treatment option for patients with multiple myeloma that has returned or not responded to prior therapy, potentially leading to deeper remission.
What could go wrong
This is a small, early-phase trial with only 30 participants, so results may not apply to all patients. The drug combination may cause side effects and may not work better than current standard treatments.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University of Miami
RECRUITINGMiami, Florida, 33136, United States
Contact
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••