Second dose of experimental drug may help when first fails

NCT ID NCT07039422

Recruiting now Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests whether a second course of ianalumab can help adults with two rare blood disorders—immune thrombocytopenia (ITP) and warm-antibody autoimmune hemolytic anemia (wAIHA)—who previously responded to the drug but then stopped responding. About 60 participants will receive ianalumab by IV infusion. The goal is to see if it can control the disease again without major side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

ianalumab (a biologic drug given by IV infusion)

What this could lead to

If successful, this could show that a second course of ianalumab helps control ITP or wAIHA when the first course stops working.

What could go wrong

This is a small, early-phase study (60 people) with no placebo group, so results may not be definitive. Risks include infusion reactions and infections.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

autoimmune hemolytic anemia, warm type autoimmune thrombocytopenic purpura primary thrombocytopenia Purpura, Thrombocytopenic, Idiopathic

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PRIMARY IMMUNE THROMBOCYTOPENIA WARM AUTOIMMUNE HEMOLYTIC ANEMIA

Contacts and locations

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Study contacts

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Locations

Novartis Investigative Site
RECRUITING

Roeselare, West-Vlaanderen, 8800, Belgium
Novartis Investigative Site
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Guangzhou, Guangdong, 510515, China
Novartis Investigative Site
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Dalian, Liaoning, 116023, China
Novartis Investigative Site
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Tianjin, 300020, China
Novartis Investigative Site
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Ostrava, Poruba, 708 52, Czechia
Novartis Investigative Site
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Caen, 14033, France
Novartis Investigative Site
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Rennes, 35033, France
Novartis Investigative Site
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Jena, Thuringia, 07740, Germany
Novartis Investigative Site
RECRUITING

Debrecen, Hajdu Bihar Megye, 4032, Hungary
Novartis Investigative Site
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Florence, FI, 50134, Italy
Novartis Investigative Site
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Roma, RM, 00168, Italy
Novartis Investigative Site
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Trieste, TS, 34129, Italy
Novartis Investigative Site
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Vicenza, VI, 36100, Italy
Novartis Investigative Site
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George Town, 10050, Malaysia
Novartis Investigative Site
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Kuala Selangor, 68000, Malaysia
Novartis Investigative Site
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Singapore, 119074, Singapore
Novartis Investigative Site
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Barcelona, 08035, Spain
Novartis Investigative Site
RECRUITING

Madrid, 28009, Spain
Novartis Investigative Site
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Murcia, 30008, Spain
Novartis Investigative Site
RECRUITING

Samsun, Atakum, 55200, Turkey (Türkiye)
Novartis Investigative Site
RECRUITING

Ankara, Bilkent Cankaya, 06800, Turkey (Türkiye)
Novartis Investigative Site
RECRUITING

London, W12 0HS, United Kingdom