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Can a platelet gel boost gum healing without surgery?

NCT ID NCT07787949

Disease control Sponsor: October 6 University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 26, 2026 · Last updated Aug 27, 2026 · Updated 1 time

Summary

This trial tests whether adding injectable platelet-rich fibrin (i-PRF) to a minimally invasive non-surgical gum treatment helps heal grade II furcation defects—areas where bone loss has occurred between tooth roots. Adults with stage III, grade B periodontitis and such defects will receive either the non-surgical technique alone or with i-PRF injections. The study measures changes in bone fill and gum attachment over six months to see if the combination improves healing.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Injectable platelet-rich fibrin (i-PRF) combined with minimally invasive non-surgical technique (MINST)
What this could lead to
If effective, this combination could improve bone and gum attachment healing in furcation defects, potentially reducing the need for surgery.
What could go wrong
This is a small early-stage trial, and the added benefit of i-PRF over MINST alone is uncertain. Results may not apply to all patients or defect types.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2026

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients of both genders \>18 years old, medically free of systemic diseases affecting periodontal regeneration. * Diagnosis of stage III, grade B periodontitis (according to the AAP/EFP classification 2018) with the presence of class II furcation defect in either the maxillary (buccal) or mandibular arch (buccal or lingual) as determined by clinical evaluation and confirmed by radiographic evaluation. * Gingival margin and interdental bone positioned coronally to the furcation entrance. * Commitment to maintenance visits and follow-up. * Absence of primary endodontic lesions. Exclusion Criteria: * Patients suffering from any systemic diseases that may affect the outcome of periodontal therapy, including diabetes, immune deficiencies, etc; * Patients that received periodontal surgical treatments in the past 12 months. * Smoking (current or in past 5 years) * Prolonged treatment with antibiotics or anti-inflammatory agents within 6 months prior to periodontal therapy. * Pregnant and lactating females. * Teeth with hopeless prognosis * Third molars

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Conditions

The condition(s) this trial relates to.

chronic periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Grade II furcation defects Injectable platelet-rich fibrin Minimally invasive Non-surgical technique

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • October 6 University (Faculty of Dentistry)

    RECRUITING

    Giza, Giza Governorate, 12511, Egypt

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