Race for new lung scarring treatment hits clinical trial hurdle

NCT ID NCT05032066

Terminated Disease control Sponsor: Amgen Source: ClinicalTrials.gov ↗

Summary

This study tested an experimental oral drug called HZN-825 to see if it could slow the progression of lung scarring in people with idiopathic pulmonary fibrosis (IPF). About 153 participants were randomly assigned to receive either the drug at one of two doses or a placebo for one year, with an option for a second year of open-label treatment. The main goal was to see if the drug could better preserve lung function, measured by a breathing test, compared to a placebo. The trial was terminated by the sponsor.

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Contacts and locations

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Locations

Asan Medical Center-PPDS

Seoul, 05505, South Korea
Athens Medical Center

Marousi, Attica, 151 25, Greece
Azienda Ospedaliera Universitaria Senese

Siena, 53100, Italy
Box Hill Hospital

Box Hill, Victoria, 3128, Australia
CICUM San Miguel

Guadalajara, Jalisco, 44160, Mexico
Central Florida Pulmonary Group PA

Orlando, Florida, 32803, United States
Centro Medico Dra de Salvo

Ciudad de Buenos Aires, C1426ABP, Argentina
Centro Respiratorio Integral LTDA. (CENRESIN)

Quillota, Región de Valparaíso, 2260000, Chile
Centro de Investigacion del Maule

Talca, 3465586, Chile
Centro de Investigación Curico

Curicó, Maule Region, 3440000, Chile
China Medical University Hospital - PPDS

Taichung, 404, Taiwan
Clinical Research Chile SpA

Valdivia, 8330033, Chile
Clinical Research of Gastonia

Gastonia, North Carolina, 28054, United States
Clinical Research of Rock Hill

Rock Hill, South Carolina, 29732, United States
Clinical Trials Center of Middle Tennessee

Franklin, Tennessee, 37067, United States
Connolly Hospital Blanchardstown

Liverpool, L9 7AL, United Kingdom
DBC Research Corp.

Tamarac, Florida, 33321, United States
Dartmouth Hitchcock Medical Center

Lebanon, New Hampshire, 03756-1000, United States
Dr. Ismail Abdullah Private Practice

Cape Town, Western Cape, 7764, South Africa
Dynamic Drug Advancement Ltd.

Ajax, Ontario, L1S 2J5, Canada
El Paso Pulmonary Association - Elligo

El Paso, Texas, 79902-1124, United States
Enroll SpA

Providencia, Región-MetropolitanadeSantiago, 7500587, Chile
Erasmus MC

Rotterdam, 3015 GD, Netherlands
Evangelismos General Hospital of Athens

Athens, Attica, 10676, Greece
Far Eastern Memorial Hospital

Taipei, 220, Taiwan
GCP Clinical Research

Tampa, Florida, 33609, United States
Hiroshima Prefectural Hospital

Hiroshima, 734-0004, Japan
Hopital Haut Leveque

Pessac, Gironde, 33604, France
Hopital Nord AP-HM

Marseille, Bouches-du-Rhône, 13915, France
Hospital Universitario 12 de Octubre

Madrid, 28041, Spain
Hospital Universitario Dr. Jose Eleuterio González

Monterrey, Nuevo León, 64460, Mexico
Hospital Universitario Quironsalud Madrid

Pozuelo de Alarcón, Madrid, 28223, Spain
Hospital Universitario de Bellvitge

L'Hospitalet de Llobregat, Barcelona, 08907, Spain
Hôpital Bretonneau

Tours, Indre-et-Loire, 37044, France
Instituto Ave Pulmo

Mar del Plata, Buenos Aires, 7600, Argentina
Instituto De Enfermedades Respiratorias E Investigacion Medica

San Juan Bautista, Buenos Aires, 1888, Argentina
Instituto De Patologías Respiratorias

San Miguel de Tucumán, Tucumán Province, 4000, Argentina
Instituto Del Buen Aire

Santa Fe, 3000, Argentina
Kanagawa Cardiovascular and Respiratory Center

Yokohama, Kanagawa, 235-0041, Japan
Kaohsiung Medical University - Chung-Ho Memorial Hospital

Kaohsiung City, 807, Taiwan
Kocaeli University Hospital

Kocaeli, 41380, Turkey (Türkiye)
Korea University Anam Hospital

Seoul, 02841, South Korea
KwaPhila Health Solutions

Durban, KwaZulu-Natal, 4091, South Africa
Lungenklinik Hemer

Hemer, North Rhine-Westphalia, 58675, Germany
MCM Krakow - PRATIA - PPDS

Krakow, 30-510, Poland
MIRES/MYF estudios cli-nicos

Ñuñoa, Región-MetropolitanadeSantiago, 7750495, Chile
Medical Hospital of Tokyo Medical and Dental University

Tokyo, 113-8519, Japan
Meditek Ltda

Santiago, Región-MetropolitanadeSantiago, 8330008, Chile
Metroplex Pulmonary and Sleep Medicine Center

McKinney, Texas, 75069, United States
National Hospital Organization Himeji Medical Center

Himeji-Shi, Hyôgo, 670-8520, Japan
National Hospital Organization Ibarakihigashi National Hospital

Naka-Gun, Ibaraki, 319-1113, Japan
National Hospital Organization Kinki-Chuo Chest Medical Center

Sakaishi, Ôsaka, 591-8025, Japan
Nebraska Pulmonary Specialties LLC

Lincoln, Nebraska, 68510, United States
Northwestern Memorial Hospital

Milwaukee, Wisconsin, 53226-3522, United States
Oaxaca Site management Organization (OSMO)

Centro, Oaxaca, 68000, Mexico
PULMAG Grzegorz Gasior Marzena Kociolek Spolka Cywilna

Katowice, Silesian Voivodeship, 40-752, Poland
Palmtree Clinical Research

Palm Springs, California, 92262, United States
Presidio Ospedaliero GB Morgagni L Pierantoni

Forlì, Emilia-Romagna, 47121, Italy
Royal Adelaide Hospital

Adelaide, South Australia, 5000, Australia
STAT Research S.A.

Ciudad Autónoma de Buenos Aires, Buenos Aires, C1013AAB, Argentina
Samsung Medical Center

Seoul, South Korea
Seoul National University Bundang Hospital

Seongnam-si, Gyeonggido, 13620, South Korea
Shelby Clinical Research

Shelby, North Carolina, 28150, United States
Southeastern Research Center

Winston-Salem, North Carolina, 27103, United States
St. Francis Medical Institute

Clearwater, Florida, 33765, United States
St. Joseph's Healthcare Hamilton

Hamilton, Ontario, L8N 4A6, Canada
Stony Brook Medicine Advanced Specialty Care

Commack, New York, 11725, United States
Taipei Veterans General Hospital

Taipei, Taiwan
Temple University Hospital

Philadelphia, Pennsylvania, 19140-5103, United States
The Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States
Thomas Jefferson University

Philadelphia, Pennsylvania, 19107, United States
Unidad de Investigación Clínica En Medicina SC

Monterrey, Nuevo León, 64718, Mexico
Universidad de Los Andes

Las Condes, Región-MetropolitanadeSantiago, 7550000, Chile
University General Hospital of Heraklion

Heraklion, 711 10, Greece
University General Hospital of Ioannina

Ioannina, 455 00, Greece
University General Hospital of Larissa

Larissa, 411 10, Greece
University General Hospital of Patras

Pátrai, Achaïa, 265 04, Greece
University of Alabama at Birmingham

Birmingham, Alabama, 35233, United States
University of Cape Town Lung Institute (UCTLI)

Cape Town, Western Cape, 7700, South Africa
University of Kansas Medical Center

Kansas City, Kansas, 66160, United States
Uniwersyteckie Centrum Kliniczne

Gdansk, Pomeranian Voivodeship, Poland
Vanderbilt University Medical Center

Nashville, Tennessee, 37204, United States

Conditions

Explore the condition pages connected to this study.

IDIOPATHIC PULMONARY FIBROSIS