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Chilling donors: can cooling Brain-Dead organ donors make kidney transplants work better?

NCT ID NCT03098706

Disease control Sponsor: Nantes University Hospital Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 14, 2026 · Last updated Sep 15, 2026 · Updated 1 time

Summary

This trial tests whether cooling brain-dead organ donors to 34-35°C, called therapeutic hypothermia, helps the kidneys they donate work better in recipients. Researchers compare two groups of kidney transplant recipients: those who receive a kidney from a donor kept cool and those from a donor kept at normal body temperature. The main goal is to see if cooling reduces delayed graft function, which is when a recipient needs dialysis in the first week after transplant. The study includes 532 participants and takes place at multiple hospitals.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
therapeutic hypothermia (controlled cooling of the organ donor to 34-35°C)
What this could lead to
If cooling donors helps, it could mean more donated kidneys work right away and fewer transplant recipients need dialysis in the first week.
What could go wrong
Cooling a donor may not improve kidney function, and it carries a risk of heart rhythm problems in the donor. The trial may not show a clear benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

532 people

The number who actually took part.

Started

Nov 2017

Finished

Mar 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * For donors: legal determination of death by neurologic criteria/deceased organ donor/no medical contre-indication to donation/Information given to the authorizing surrogate/ Pregnant women. * For transplant recipients : age 18 years or greater /information given and no opposition signed by recipients. Exclusion Criteria: * For donors: no legal determination of death by neurologic criteria/not a deceased organ donor/ medical contre-indication to donation/ no Information given to the authorizing surrogate. * For transplant recipients: age \<18 years / no information given and/or opposition signed by recipients.

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Conditions

The condition(s) this trial relates to.

Brain Death Critical Illness Hypothermia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Brain death Critical illness Hypothermia Kidney transplant; complications Organ donor

Contacts and locations

Locations

  • CH Angouleme

    Angoulême, 16959, France

  • CH Annecy Genevois

    Pringy, 74374, France

  • CH Avignon

    Avignon, 84000, France

  • CH Bourges

    Bourges, 18020, France

  • CH Cornouaille

    Quimper, 29107, France

  • CH La Roche sur Yon

    La Roche-sur-Yon, 85925, France

  • CH La Rochelle

    La Rochelle, 17019, France

  • CH Laval

    Laval, 53000, France

  • CH Le Mans

    Le Mans, 72037, France

  • CH Lorient

    Lorient, 56322, France

  • CH Marne la Vallée (GHEF)

    Jossigny, 77600, France

  • CH Morlaix

    Morlaix, 29672, France

  • CH Orléans

    Orléans, 45067, France

  • CH Saint Brieuc

    Saint-Brieuc, 22027, France

  • CH Saint Malo

    St-Malo, 35403, France

  • CH Saint Nazaire

    Saint-Nazaire, 44606, France

  • CH Saintes

    Saintes, 17108, France

  • CH Vannes

    Vannes, 56000, France

  • CH de Blois

    Blois, 41016, France

  • CH de Dreux

    Dreux, 28100, France

  • CH de Meaux (GHEF)

    Meaux, France

  • CHRU Lille

    Lille, 59000, France

  • CHRU Nancy

    Vandœuvre-lès-Nancy, 54511, France

  • CHRU Saint-Etienne

    Saint-Etienne, 42055, France

  • CHU Amiens-Picardie

    Amiens, 80054, France

  • CHU Brest

    Brest, 29200, France

  • CHU Caen

    Caen, 14000, France

  • CHU Foch

    Suresnes, 92150, France

  • CHU Grenoble

    Grenoble, France

  • CHU Limoges

    Limoges, 87042, France

  • CHU Montpellier

    Montpellier, France

  • CHU Nice

    Nice, 06000, France

  • CHU Poitiers

    Poitiers, 86000, France

  • CHU Reims

    Reims, 51100, France

  • CHU Rennes

    Rennes, 35000, France

  • CHU Rouen

    Rouen, 76000, France

  • CHU Strasbourg

    Strasbourg, 67091, France

  • CHU Tenon

    Paris, 75020, France

  • CHU Toulouse

    Toulouse, 31403, France

  • CHU Tours

    Tours, 37044, France

  • CHU d'Angers

    Angers, 49000, France

  • CHU de Bordeaux

    Bordeaux, 33076, France

  • CHU de Dijon

    Dijon, 21079, France

  • CHU de Lyon

    Lyon, France

  • Ch Cholet

    Cholet, 49325, France

  • Chu Clermont Ferrand

    Clermont-Ferrand, France

  • Hopital Bicetre

    Le Kremlin-Bicêtre, 94270, France

  • Hopital Henri Mondor

    Créteil, 94000, France

  • Hopital Necker

    Paris, 75015, France

  • Hopital Saint Louis

    Paris, 75010, France

  • Hopital de la Conception

    Marseille, 13005, France

  • Hopital de la Pitié Salpetriere

    Paris, 75013, France

  • Hopital de la Timone

    Marseille, 13005, France

  • Nantes University Hospital

    Nantes, 44093, France

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