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Could a stronger dose of an old drug protect children with sickle cell from organ damage?

NCT ID NCT07708714

Recruiting now Disease control Sponsor: Children's Hospital Medical Center, Cincinnati Source: ClinicalTrials.gov ↗

First seen Jul 16, 2026 · Last updated Jul 17, 2026 · Updated 1 time

Summary

This study tests whether a higher, personalized dose of hydroxyurea is safe and works better than a fixed low dose for children with sickle cell anemia who live in regions where malaria is common. The trial includes children who were already taking a fixed dose and compares them to a group not taking hydroxyurea. Researchers will check for organ damage in the brain, kidneys, and bones to see if the optimized dose offers more protection.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
hydroxyurea at an optimized dose
What this could lead to
If successful, this could show that a higher, personalized dose of hydroxyurea is safe and reduces organ damage in children with sickle cell anemia living in malaria-endemic regions.
What could go wrong
This is an early-phase extension study, so results are preliminary. The higher dose may increase risks of infections or malaria, and the benefits seen may not apply to all children.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

sickle cell disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SICKLE CELL ANEMIA IN CHILDREN SICKLE CELL DISEASE

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Mulago Hospital Sickle Cell Clinic

    RECRUITING

    Kampala, Uganda

    Contact

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