Can a drink beat water for rehydration? a new trial puts electrolyte formulas to the test
NCT ID NCT06063655
First seen Aug 19, 2026 · Last updated Aug 20, 2026 · Updated 1 time
Summary
This study tests whether two electrolyte drink mixes help adults rehydrate faster than plain water after exercise. Healthy adults will cycle in the heat to lose fluids, then drink one of the three beverages on separate visits. Researchers will measure body weight, urine output, and blood markers to see how well each drink restores hydration.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Two novel hydration beverage formulas (Liquid IV hydration multiplier and sugar-free version) compared with water
- What this could lead to
- If effective, these drinks could offer a better way to rehydrate after exercise, potentially improving recovery and performance for athletes and active people.
- What could go wrong
- This is a very small early-stage trial (7 participants), so results may not apply broadly. The drinks are supplements, not medicines, and any benefit over water is uncertain.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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7 people
The number who actually took part.
- Started
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Sep 2023
- Finished
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May 2024
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 49 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Body mass index (BMI) between 17.0-29.9 kg/m2 (not obese) * Resting heart rate less than 90 beats per minute; although, if less than 40 beats per minute subject must get clearance from a medical professional * Not hypertensive (Systolic \<140 mmHg and Diastolic \<90 mmHg) * Have not had in the 3 months prior to screening or planning to have a major surgery during study period * Physically capable and willing to ingest the assigned amount of fluid while cycling and at rest for visits 3, 4, and 5 * Must be moderately trained; engage in moderate intensity, intermittent, or steady-state exercise at least 3 days per week for at least one hour at a time. * Willing to maintain the same level of physical activity throughout the study period, except during the 24 hour period prior to each study visit. * Achieve a peak maximal oxygen consumption at screening that is at least 60% of their age and gender matched normative value per American College of Sports Medicine recommendations. * Capable of completing 90 minutes of self-paced stationary cycling (\~70-80% max heart rate) in a heated environmental chamber (\~30-32°C (86-89°F) with \~50% RH). * Can drink a minimum of 2.0 L fluid (if female) or 2.5 L fluid (if male) the day prior to test visits * For visits 3-5, subjects must have a urine specific gravity less than 1.020. * For visit 3-5, subject must not have exercised within 24 hours of visit * Consume no more than two standard alcoholic drinks per day on a regular basis and during study period. * Maintain diet, exercise, BMI, medication, and dietary supplements throughout study period as changes may alter hydration and electrolyte levels and result in changes to outcome measures. Exclusion Criteria: * If female, lactating, pregnant or planning to become pregnant during the study. * Have a known sensitivity or allergy to any of the study products * Have a history of diabetes * Have a history of known cardiovascular disease * Have a history of a diagnosis of celiac disease, chronic pancreatitis, steatorrhea, unstable thyroid disease, immune disorder (i.e., HIV/AIDS), cancer (except localized skin cancer without metastases or in situ cervical cancer within 5 years prior to screening visit). * Have an active or uncontrolled diseases or conditions * Have had a current or previous Corona virus disease 2019 diagnosis in the three months prior to screening. * Have any medical conditions that may impact ability to exercise or ability to ingest prescribed fluid volume as determined by the study nurse, including infection or illness * Weighing less than 80 lbs at any visit; although very unlikely, we need to maintain this cut off, as too low a body mass is unhealthy. * Has taken within 30 days or within seven half-lives (whichever is longer) of first test visit: selective serotonin uptake inhibitors (SSRI), Apremilast, caffeine-containing drugs, Corticosteroids (systemic use), Decongestants, Diuretics, Laxatives, Muscle relaxants, Opioid painkillers, Statins, Oral antibiotics * Has taken within 30 days of first test visit: Calcium, Dandelion, Lithium orotate, Potassium citrate, Watercress, Inhalables smokables, or the like cigarettes, vaporizers, water pipes, or cannabis * Has taken within 24 hours prior to test visit: Alcohol, Caffeine (including coffee, tea, energy drinks, etc. prohibited in the 12hrs prior to each dose of the study product), Laxatives, Diuretics, or Sports drinks (electrolyte drinks) * received or use test product(s) in another research study in the 28 days prior to baseline visit (Familiarization, Visit/Visit 2), or longer if the previous test product is deemed by the investigator to have lasting effects that might influence the eligibility criteria or outcomes of the current study. * have any other active or unstable medical conditions or use medications, supplements, or therapies that, in the opinion of the investigator, may adversely affect the participant's ability to complete the study or its measures or pose a significant risk to the participant.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Center for Nutraceutical and Dietary Supplement Research
Memphis, Tennessee, 38152, United States
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