New heart procedure aims to tame racing heartbeat without drugs

NCT ID NCT05280093

Ongoing Symptom relief Sponsor: AtriCure, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a hybrid surgical ablation procedure for people with inappropriate sinus tachycardia (IST), a condition where the heart beats too fast without a clear cause. The procedure uses a device to carefully target heart tissue while sparing the sinus node. Researchers want to see if it safely reduces heart rate and improves symptoms like breathlessness and fatigue in 142 patients who haven't responded to medications.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Hybrid sinus node sparing ablation procedure using the AtriCure ISOLATOR Synergy Surgical Ablation System

What this could lead to

If successful, this could offer a new treatment option for people with inappropriate sinus tachycardia who don't get relief from medications.

What could go wrong

This is an early-stage study with no control group, so results may not be definitive. The procedure is invasive and carries risks like any heart surgery.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INAPPROPRIATE SINUS TACHYCARDIA

Contacts and locations

Show contact details

Locations

Amsterdam University Medical Center

Amsterdam, Netherlands
Baptist Health

Miami, Florida, 33143, United States
Central Clinic Hospital

Warsaw, Poland
Intermountain Healthcare

Salt Lake City, Utah, 84111, United States
Kansas City Cardiac Arrhythmia Research LLC

Overland Park, Kansas, 66211, United States
Loma Linda University Health

Loma Linda, California, 92354, United States
Maastricht University Medical Center

Maastricht, Netherlands
Mayo Clinic

Rochester, Minnesota, 55905, United States
Medstar Washington Hospital Center

Washington D.C., District of Columbia, 20010, United States
Memorial Health University Medical Center

Savannah, Georgia, 31404, United States
Northern General Hospital

Sheffield, S5 7AU, United Kingdom
Saint Alphonsus Regional Medical Center

Boise, Idaho, 83706, United States
Saint Vincent's Medical Center

Bridgeport, Connecticut, 06606, United States
San Raffaele Hospital

Milan, Italy
Sarasota Memorial Hospital

Sarasota, Florida, 34239, United States
Sequoia Hospital

Redwood City, California, 94062, United States
St. Bernard

Jonesboro, Arkansas, 72401, United States
St. Joseph's Hospital / Baycare Health System

Tampa, Florida, 33607, United States
Stanford University

Redwood City, California, 94063, United States
Swedish Medical Center

Seattle, Washington, 98122, United States
Texas Cardiac Arrhythmia Research Foundation

Austin, Texas, 78705, United States
The Christ Hospital

Cincinnati, Ohio, 45219, United States
TriHealth, Inc.

Cincinnati, Ohio, 45202, United States
UZ Brussels

Brussels, Belgium
University of Florida

Gainesville, Florida, 32610, United States
Virginia Commonwealth University

Richmond, Virginia, 23219, United States
Wake Forest University Health Sciences

Winston-Salem, North Carolina, 27157, United States