Can engineered immune cells tame autoimmune anemia?
NCT ID NCT07748533
First seen Aug 05, 2026 · Last updated Aug 06, 2026 · Updated 1 time
Summary
This early-stage trial is testing an experimental treatment called HY001N, a type of CAR-T cell therapy, in adults with autoimmune hemolytic anemia (AIHA) who have not improved after three or more standard treatments. The goal is to see if the therapy is safe and tolerable, and whether it can help restore normal red blood cell levels and reduce the disease's symptoms. Participants will receive the cell infusion and be monitored closely for side effects and response.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- HY001N cell injection (CAR-T cell therapy)
- What this could lead to
- If successful, this could lead to a new treatment option for people with autoimmune hemolytic anemia who have not responded to standard therapies, potentially offering a durable remission.
- What could go wrong
- This is an early-phase trial with only 9 participants, so results may not apply broadly. CAR-T therapy carries risks of severe side effects, and the treatment may not work for everyone.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Institute of Hematology & Blood Diseases Hospital
RECRUITINGTianjin, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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