A second chance at prevention: could provider training shield cancer survivors from HPV-Related cancers?

NCT ID NCT04469569

First seen Aug 03, 2026 · Last updated Aug 04, 2026 · Updated 1 time

Summary

This trial tests whether a program that trains pediatric oncology providers—called HPV-PROTECT—can increase HPV vaccination among young cancer survivors aged 9 to 17 who are at least one year past treatment. These survivors face a higher risk of new cancers caused by HPV, yet vaccination rates are low. The program includes communication training, peer feedback, and a toolkit to help providers make strong vaccine recommendations. The study will compare clinics using the program to those providing usual care, measuring how many survivors start the HPV vaccine series.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
HPV-PROTECT, a provider-focused behavioral intervention including communication training, peer feedback, and a toolkit
What this could lead to
If effective, this approach could increase HPV vaccination among young cancer survivors, potentially preventing HPV-related cancers in this high-risk group.
What could go wrong
The trial's success depends on provider behavior change and may not generalize beyond participating clinics. Vaccine uptake could remain low due to other barriers.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Baylor College of Medicine

    Houston, Texas, 77030-3411, United States

  • Emory University

    Atlanta, Georgia, 30322, United States

  • Oregon Health and Science University

    Portland, Oregon, 97239-3098, United States

  • University of Alabama at Birmingham

    Birmingham, Alabama, 35233, United States

  • University of Minnesota

    Minneapolis, Minnesota, 55455-0341, United States

  • Wake Forest University Health Sciences

    Winston-Salem, North Carolina, 27157-0001, United States

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