Major cancer trial tests gentler treatment for HPV-Linked throat cancer

NCT ID NCT01302834

Completed Disease control Sponsor: Radiation Therapy Oncology Group Source: ClinicalTrials.gov ↗

Summary

This large, completed study aimed to find the best way to treat throat cancer caused by the human papillomavirus (HPV). It compared the standard treatment of radiation plus a chemotherapy drug (cisplatin) against radiation plus a different, targeted drug (cetuximab). The main goal was to see if the newer combination was just as good at helping patients live longer, while also comparing side effects and quality of life.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Study site

Santa Clara, California, 95051, United States
Adams Cancer Center

Gettysburg, Pennsylvania, 17325, United States
Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210-1240, United States
Auburn Radiation Oncology

Auburn, California, 95603, United States
Baptist Cancer Institute - Jacksonville

Jacksonville, Florida, 32207, United States
Baptist Medical Center South

Jacksonville, Florida, 32258, United States
Barberton Citizens Hospital

Barberton, Ohio, 44203, United States
Barnes-Jewish West County Hospital

St Louis, Missouri, 63141, United States
Battle Creek Health System Cancer Care Center

Battle Creek, Michigan, 49017, United States
Bay Area Cancer Care Center at Bay Area Medical Center

Marinette, Wisconsin, 54143, United States
Billings Clinic - Downtown

Billings, Montana, 59107-7000, United States
Blumenthal Cancer Center at Carolinas Medical Center

Charlotte, North Carolina, 28232-2861, United States
Boulder Community Hospital

Boulder, Colorado, 80301-9019, United States
Butterworth Hospital at Spectrum Health

Grand Rapids, Michigan, 49503, United States
CCOP - Christiana Care Health Services

Newark, Delaware, 19713, United States
CCOP - Greenville

Greenville, South Carolina, 29615, United States
CCOP - Kansas City

Prairie Village, Kansas, 66208, United States
CCOP - Ochsner

New Orleans, Louisiana, 70121, United States
CCOP - St. Louis-Cape Girardeau

St Louis, Missouri, 63141, United States
CCOP - Virginia Mason Research Center

Seattle, Washington, 98101, United States
Cancer Center at Ball Memorial Hospital

Muncie, Indiana, 47303-3499, United States
Cancer Centers of the Carolinas - Faris Road

Greenville, South Carolina, 29605, United States
Cancer Centers of the Carolinas - Spartanburg

Spartanburg, South Carolina, 29307, United States
Cancer Institute at St. John's Hospital

Springfield, Illinois, 62702, United States
Cancer Institute of Cape Girardeau, LLC

Cape Girardeau, Missouri, 63703, United States
Cancer Institute of New Jersey at Cooper - Voorhees

Voorhees Township, New Jersey, 08043, United States
Cancer Treatment Center

Wooster, Ohio, 44691, United States
CancerCare Manitoba

Winnipeg, Manitoba, R3E 0V9, Canada
Cardinal Bernardin Cancer Center at Loyola University Medical Center

Maywood, Illinois, 60153, United States
Case Comprehensive Cancer Center

Cleveland, Ohio, 44106-5065, United States
Center for Cancer Care at Goshen General Hospital

Goshen, Indiana, 46526, United States
Charles M. Barrett Cancer Center at University Hospital

Cincinnati, Ohio, 45267, United States
Cherry Tree Cancer Center

Hanover, Pennsylvania, 17331, United States
City of Hope Comprehensive Cancer Center

Duarte, California, 91010-3000, United States
Clackamas Radiation Oncology Center

Clackamas, Oregon, 97015, United States
Cleveland Clinic Cancer Center at Fairview Hospital

Cleveland, Ohio, 44111, United States
Cleveland Clinic Taussig Cancer Center

Cleveland, Ohio, 44195, United States
Coastal Cancer Center at Sentara Virginia Beach General Hospital

Virginia Beach, Virginia, 23454, United States
Community Regional Cancer Care at Community Hospital East

Indianapolis, Indiana, 46219, United States
Community Regional Cancer Care at Community Hospital North

Indianapolis, Indiana, 46256, United States
Creticos Cancer Center at Advocate Illinois Masonic Medical Center

Chicago, Illinois, 60657, United States
Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center

Savannah, Georgia, 31403-3089, United States
Dale and Frances Hughes Cancer Center at Pocono Medical Center

East Stroudsburg, Pennsylvania, 18301, United States
David C. Pratt Cancer Center at St. John's Mercy

St Louis, Missouri, 63141, United States
Decatur Memorial Hospital Cancer Care Institute

Decatur, Illinois, 62526, United States
Dubs Cancer Center at Rogue Valley Medical Center

Medford, Oregon, 97504, United States
Edwards Comprehensive Cancer Center at Cabell Huntington Hospital

Huntington, West Virginia, 25701, United States
Elkhart General Hospital

Elkhart, Indiana, 46515, United States
Enloe Cancer Center at Enloe Medical Center

Chico, California, 95926, United States
Evanston Hospital

Evanston, Illinois, 60201-1781, United States
Fairview Southdale Hospital

Edina, Minnesota, 55435, United States
FirstHealth Moore Regional Community Hospital Comprehensive Cancer Center

Pinehurst, North Carolina, 28374, United States
Flagler Cancer Center

Saint Augustine, Florida, 32086, United States
Florida Cancer Center - Palatka

Palatka, Florida, 32177, United States
Florida Hospital Cancer Institute at Florida Hospital Orlando

Orlando, Florida, 32803-1273, United States
Flower Hospital Cancer Center

Sylvania, Ohio, 43560, United States
Fox Chase Cancer Center - Philadelphia

Philadelphia, Pennsylvania, 19111-2497, United States
Frederick R. and Betty M. Smith Cancer Treatment Center

Sparta, New Jersey, 07871, United States
Genesys Hurley Cancer Institute

Flint, Michigan, 48503, United States
George Bray Cancer Center at the Hospital of Central Connecticut - New Britain Campus

New Britain, Connecticut, 06050, United States
Georgia Cancer Center for Excellence at Grady Memorial Hospital

Atlanta, Georgia, 30303, United States
Gibbs Regional Cancer Center at Spartanburg Regional Medical Center

Spartanburg, South Carolina, 29303, United States
Greenebaum Cancer Center at University of Maryland Medical Center

Baltimore, Maryland, 21201, United States
Gundersen Lutheran Center for Cancer and Blood

La Crosse, Wisconsin, 54601, United States
H. Lee Moffitt Cancer Center and Research Institute at University of South Florida

Tampa, Florida, 33612-9497, United States
Highland Hospital of Rochester

Rochester, New York, 14620, United States
Hillcrest Cancer Center at Hillcrest Hospital

Mayfield Heights, Ohio, 44124, United States
Hollings Cancer Center at Medical University of South Carolina

Charleston, South Carolina, 29425, United States
Hudner Oncology Center at Saint Anne's Hospital - Fall River

Fall River, Massachusetts, 02721, United States
Hulston Cancer Center at Cox Medical Center South

Springfield, Missouri, 65807, United States
Huntsman Cancer Institute at University of Utah

Salt Lake City, Utah, 84112, United States
Integrated Community Oncology Network

Jacksonville Beach, Florida, 32250, United States
Integrated Community Oncology Network - Orange Park

Orange Park, Florida, 32073, United States
Integrated Community Oncology Network at Southside Cancer Center

Jacksonville, Florida, 32207, United States
James Graham Brown Cancer Center at University of Louisville

Louisville, Kentucky, 40202, United States
James P. Wilmot Cancer Center at University of Rochester Medical Center

Rochester, New York, 14642, United States
John H. Stroger, Jr. Hospital of Cook County

Chicago, Illinois, 60612-3785, United States
John Stoddard Cancer Center at Iowa Methodist Medical Center

Des Moines, Iowa, 50309, United States
Jon and Karen Huntsman Cancer Center at Intermountain Medical Center

Murray, Utah, 84157, United States
Josephine Ford Cancer Center at Henry Ford Hospital

Detroit, Michigan, 48202, United States
Kaiser Permanente - Division of Research - Oakland

Oakland, California, 94611, United States
Kaiser Permanente Medical Center - South San Francisco

South San Francisco, California, 94080, United States
Kansas City Cancer Centers - North

Kansas City, Missouri, 64154, United States
Kansas City Cancer Centers - South

Kansas City, Missouri, 64131, United States
Kansas City Cancer Centers - Southwest

Overland Park, Kansas, 66210, United States
Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center

Kansas City, Kansas, 66160-7357, United States
Kingsbury Center for Cancer Care at Cheshire Medical Center

Keene, New Hampshire, 03431, United States
Kinston Medical Specialists

Kinston, North Carolina, 28501, United States
Knight Cancer Institute at Oregon Health and Science University

Portland, Oregon, 97239-3098, United States
Lacks Cancer Center at Saint Mary's Health Care

Grand Rapids, Michigan, 49503, United States
Lahey Clinic Medical Center - Burlington

Burlington, Massachusetts, 01805, United States
Lake/University Ireland Cancer Center

Mentor, Ohio, 44060, United States
Lourdes Regional Cancer Center

Binghamton, New York, 13905, United States
Lucille P. Markey Cancer Center at University of Kentucky

Lexington, Kentucky, 40536-0093, United States
M. D. Anderson Cancer Center at University of Texas

Houston, Texas, 77030-4009, United States
M.D. Anderson Cancer Center at Orlando

Orlando, Florida, 32806, United States
Maine Center for Cancer Medicine and Blood Disorders - Scarborough

Scarborough, Maine, 04074, United States
Mary Bird Perkins Cancer Center - Baton Rouge

Baton Rouge, Louisiana, 70809, United States
McFarland Clinic, PC

Ames, Iowa, 50010, United States
McGill Cancer Centre at McGill University

Montreal, Quebec, H2W 1S6, Canada
McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center

Reading, Pennsylvania, 19612-6052, United States
McKee Medical Center

Loveland, Colorado, 80539, United States
Medical College of Wisconsin Cancer Center

Milwaukee, Wisconsin, 53226, United States
Memorial Hospital of South Bend

South Bend, Indiana, 46601, United States
Mercy Cancer Center at Mercy San Juan Medical Center

Carmichael, California, 95608, United States
Mercy General Hospital

Sacramento, California, 95819, United States
Mercy and Unity Cancer Center at Mercy Hospital

Coon Rapids, Minnesota, 55433, United States
Mercy and Unity Cancer Center at Unity Hospital

Fridley, Minnesota, 55432, United States
Methodist Estabrook Cancer Center

Omaha, Nebraska, 68114, United States
Michiana Hematology-Oncology, PC - South Bend

Mishawaka, Indiana, 46545-1470, United States
Mission Hospitals - Memorial Campus

Asheville, North Carolina, 28801, United States
Monmouth Medical Center

Long Branch, New Jersey, 07740-6395, United States
Moses Cone Regional Cancer Center at Wesley Long Community Hospital

Greensboro, North Carolina, 27403-1198, United States
NSMC Cancer Center - Peabody

Danvers, Massachusetts, 01923, United States
Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler

Savannah, Georgia, 31405, United States
Natalie Warren Bryant Cancer Center at St. Francis Hospital

Tulsa, Oklahoma, 74136, United States
Nebraska Medical Center

Omaha, Nebraska, 68198, United States
Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center

Lebanon, New Hampshire, 03756-0002, United States
North Broward Medical Center

Deerfield Beach, Florida, 33064-3596, United States
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital

Yakima, Washington, 98902, United States
North Suburban Medical Center

Thornton, Colorado, 80229, United States
Northeast Georgia Medical Center

Gainesville, Georgia, 30501, United States
Northwest Cancer Specialists at Vancouver Cancer Center

Vancouver, Washington, 98684, United States
Northwest Community Hospital

Arlington Heights, Illinois, 60005, United States
Northwest Ohio Oncology Center

Maumee, Ohio, 43537-1839, United States
Oklahoma University Cancer Institute

Oklahoma City, Oklahoma, 73104, United States
Park Nicollet Cancer Center

Saint Louis Park, Minnesota, 55416, United States
Parkview Regional Cancer Center at Parkview Health

Fort Wayne, Indiana, 46805, United States
Payson Center for Cancer Care at Concord Hospital

Concord, New Hampshire, 03301, United States
Penrose Cancer Center at Penrose Hospital

Colorado Springs, Colorado, 80933, United States
Porter Adventist Hospital

Denver, Colorado, 80210, United States
Precision Radiotherapy at University Pointe

West Chester, Ohio, 45069, United States
Providence Cancer Center

Anchorage, Alaska, 99508, United States
Providence Cancer Center at PMCC

Medford, Oregon, 97504, United States
Providence Cancer Center at Providence Portland Medical Center

Portland, Oregon, 97213-2967, United States
Providence St. Vincent Medical Center

Portland, Oregon, 97225, United States
Radiation Oncology Center - Roseville

Roseville, California, 95661, United States
Radiation Oncology Centers - Cameron Park

Cameron Park, California, 95682, United States
Radiological Associates of Sacramento Medical Group, Incorporated

Sacramento, California, 95815, United States
Rapid City Regional Hospital

Rapid City, South Dakota, 57701, United States
Rebecca and John Moores UCSD Cancer Center

La Jolla, California, 92093-0658, United States
Regional Cancer Center at Memorial Medical Center

Springfield, Illinois, 62781-0001, United States
Regional Cancer Center at Singing River Hospital

Pascagoula, Mississippi, 39581, United States
Regions Hospital Cancer Care Center

Saint Paul, Minnesota, 55101, United States
Renown Institute for Cancer at Renown Regional Medical Center

Reno, Nevada, 89502, United States
Robert H. Lurie Comprehensive Cancer Center at Northwestern University

Chicago, Illinois, 60611-3013, United States
Rocky Mountain Cancer Centers - Aurora

Aurora, Colorado, 80012, United States
Rohnert Park Cancer Center

Rohnert Park, California, 94928, United States
Rosenfeld Cancer Center at Abington Memorial Hospital

Abington, Pennsylvania, 19001, United States
Roy and Patricia Disney Family Cancer Center at Providence Saint Joseph Medical Center

Burbank, California, 91505, United States
Sacred Heart Cancer Center at Sacred Heart Hospital

Pensacola, Florida, 32504, United States
Saint Joseph Mercy Cancer Center

Ann Arbor, Michigan, 48106-0995, United States
Schiffler Cancer Center at Wheeling Hospital

Wheeling, West Virginia, 26003, United States
Seacoast Cancer Center at Wentworth - Douglass Hospital

Dover, New Hampshire, 03820, United States
Sentara Cancer Institute at Sentara Norfolk General Hospital

Norfolk, Virginia, 23507, United States
Siouxland Hematology-Oncology Associates, LLP

Sioux City, Iowa, 51101, United States
Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis

St Louis, Missouri, 63110, United States
Solano Radiation Oncology Center

Vacaville, California, 95687, United States
Southwest General Health Center

Middleburg Heights, Ohio, 44130, United States
St. Agnes Hospital Cancer Center

Baltimore, Maryland, 21229, United States
St. Anne Mercy Hospital

Toledo, Ohio, 43623, United States
St. Charles Mercy Hospital

Oregon, Ohio, 43616, United States
St. Francis Hospital and Health Centers - Beech Grove Campus

Beech Grove, Indiana, 46107, United States
St. Joseph Cancer Center

Bellingham, Washington, 98225, United States
St. Mary Regional Cancer Center

Langhorne, Pennsylvania, 19047, United States
St. Mary's Hospital Medical Center - Green Bay

Green Bay, Wisconsin, 54303, United States
St. Vincent Hospital Regional Cancer Center

Green Bay, Wisconsin, 54307-3508, United States
Summa Center for Cancer Care at Akron City Hospital

Akron, Ohio, 44309-2090, United States
Swedish Medical Center

Englewood, Colorado, 80110, United States
Theda Care Cancer Institute

Appleton, Wisconsin, 54911, United States
UCSF Helen Diller Family Comprehensive Cancer Center

San Francisco, California, 94115, United States
UHHS Westlake Medical Center

Westlake, Ohio, 44145, United States
University of Chicago Cancer Research Center

Chicago, Illinois, 60637-1470, United States
University of Miami Sylvester Comprehensive Cancer Center - Miami

Miami, Florida, 33136, United States
University of New Mexico Cancer Center

Albuquerque, New Mexico, 87131-5636, United States
University of Texas Medical Branch

Galveston, Texas, 77555-0361, United States
University of Wisconcin Cancer Center at Aspirus Wausau Hospital

Wausau, Wisconsin, 54401, United States
University of Wisconsin Paul P. Carbone Comprehensive Cancer Center

Madison, Wisconsin, 53792-6164, United States
Utah Cancer Specialists at UCS Cancer Center

Salt Lake City, Utah, 84106, United States
Utah Valley Regional Medical Center - Provo

Provo, Utah, 84604, United States
Val and Ann Browning Cancer Center at McKay-Dee Hospital Center

Ogden, Utah, 84403, United States
Vanderbilt-Ingram Cancer Center

Nashville, Tennessee, 37232-6838, United States
Veterans Affairs Medical Center - Milwaukee

Milwaukee, Wisconsin, 53295, United States
Winship Cancer Institute of Emory University

Atlanta, Georgia, 30322, United States
York Cancer Center at Apple Hill Medical Center

York, Pennsylvania, 17405, United States

Conditions

Explore the condition pages connected to this study.

HEAD AND NECK CANCER PRECANCEROUS CONDITION