New pill could help adults with low platelet disorder

NCT ID NCT05029635

Completed Disease control Sponsor: Hutchmed Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 3 trial tested an oral drug called HMPL-523 (sovleplenib) in 272 adults with chronic immune thrombocytopenia (ITP), a condition where the immune system destroys platelets, causing bleeding risks. Participants who had not responded well to prior treatments received either the drug or a placebo daily for 24 weeks. The study measured whether platelet counts could be raised and maintained at safe levels.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: HMPL-523 (sovleplenib)
What this could lead to: If successful, this could provide a new oral treatment option for adults with chronic ITP who have not responded well to standard therapies.
What could go wrong: This is a completed Phase 3 trial, but results are not yet published. The drug may not prove significantly better than placebo, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

autoimmune thrombocytopenic purpura primary thrombocytopenia Purpura, Thrombocytopenic, Idiopathic

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PRIMARY IMMUNE THROMBOCYTOPENIA (ITP)

Contacts and locations

Locations

Affiliated Hospital of North China University of Technology

Tangshan, Hebei, China
Beijing Chaoyang Hospital of Capital Medical University

Beijing, Beijing Municipality, China
Blood Institute of the Chinese Academy of Medical Sciences

Tianjin, Tianjin Municipality, China
First Affiliated Hospital of Zhengzhou University

Zhengzhou, Henan, China
Fujian Medical University Union Hospital

Fuzhou, Fujian, China
Guangdong General Hospital

Guangzhou, Guangdong, China
Henan Cancer Hospital

Zhengzhou, Henan, China
Heping Hospital Affiliated to Changzhi Medical College

Changzhi, Shanxi, China
Jinan Central Hospital Affilated to Sandong University

Jinan, Shandong, China
Jinshan Hospital Affiliated To Fudan University

Shanghai, Shanghai Municipality, China
Lanzhou University Second Hospital

Lanzhou, Gansu, China
LiaoCheng People's Hospital

Liaocheng, Shandong, China
Peking Union Medical College Hospital

Beijing, Beijing Municipality, China
People's Hospital of Peking University

Beijing, Beijing Municipality, China
Qinghai province people's hospital

Xining, Qinghai, China
Ruijin Hospital, Shanghai Jiaotong University School of Medicine

Shanghai, Shanghai Municipality, China
Shanxi Provincial People's Hospital

Xi’an, Shanxi, China
Shengjing Hospital of China Medical University

Shenyang, Liaoning, China
Southern Hospital of Southern Medical University

Guangzhou, Guangdong, China
The Affiliated Hospital of Qingdao University

Qingdao, Shandong, China
The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University

Huai'an, Nanjing Province, China
The First Affiliated Hospital Of GuangXi Medical University

Nanning, Guangxi, China
The First Affiliated Hospital of Anhui Medical University

Hefei, Anhui, China
The First Affiliated Hospital of Nanchang University

Nanchang, Jiangxi, China
The First Affiliated Hospital of Soochow University

Suzhou, Jiangsu, China
The First Affiliated hospital of USTC

Hefei, Anhui, China
The First Affilicated Hospital of Xinjiang Medical University

Ürümqi, The Xinjiang Uygur Autonomous Region, China
The First Hospital of Hebei Medical University

Shijiazhuang, Hebei, China
The Second People's Hospital Of Shenzhen

Shenzhen, Guangdong, China
The Third Xiangya Hospital of Central South University

Changsha, Hunan, China
The second Affiliated Hospital of Kunming Medical University

Kunming, Yunnan, China
The second hospital of Shanxi Medical University

Taiyuan, Shanxi, China
Union Hospital affiliated to Tongji Medical College, Huazhong University of Science and Technology

Wuhan, Hubei, China
West China Hospital，Sichuan University

Chengdu, Sichuan, China
Xiangya Hospital Central South University

Changsha, Hunan, China
Xiangyang Central Hospital

Xiangyang, Hubei, China
Zhejiang Provincial Hospital of Chinese Medicine

Hangzhou, Zejiang Province, China

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