Could a shot every 6 months replace daily HIV pills?

NCT ID NCT05729568

NEW Ongoing Disease control Sponsor: Gilead Sciences Source: ClinicalTrials.gov ↗

First seen May 09, 2026 · Last updated May 09, 2026

Summary

This study tests a new combination of two broadly neutralizing antibodies and the drug lenacapavir as a long-acting HIV treatment given every 6 months. It involves 83 adults whose HIV is already well-controlled by daily pills. The goal is to see if this new regimen can keep the virus suppressed as effectively as continuing daily oral therapy.

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Contacts and locations

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Locations

AIDS Arms, Inc. DBA Prism Health North Texas

Dallas, Texas, 75208, United States
AXCES Research Group, LLC

Albuquerque, New Mexico, 87109, United States
AXCES Research Group, LLC

El Paso, Texas, 79902, United States
Alfred Hospital

Melbourne, Victoria, 3004, Australia
Can Community Health Care

Fort Lauderdale, Florida, 33316, United States
Central Texas Clinical Research

Austin, Texas, 78705, United States
Clinical Alliance for Research & Education, Infectious Diseases LLC (CARE-ID)

Annandale, Virginia, 22003, United States
Clinical Research Puerto Rico

San Juan, 909, Puerto Rico
Duke University Health Center

Durham, North Carolina, 27710, United States
East Sydney Doctors

Darlinghurst, New South Wales, 2010, Australia
Emory University Hospital Midtown Infectious Disease Clinic

Atlanta, Georgia, 30308, United States
Georgetown University Medical Center

Washington D.C., District of Columbia, 20007, United States
Holdsworth House Medical Practice

Sydney, New South Wales, 2010 NSW, Australia
Infectious Disease Specialists of Atlanta

Decatur, Georgia, 30033, United States
Maple Leaf Research/Maple Leaf Medical Clinic

Toronto, M5G 1K2, Canada
Midland Florida Clinical Research Center, LLC

DeLand, Florida, 32720, United States
Midway Immunology and Research Center

Ft. Pierce, Florida, 34982, United States
Mills Clinical Research

Los Angeles, California, 90069, United States
Montefiore Medical Center

The Bronx, New York, 10467, United States
NC TraCS Institute - CTRC; University of North Carolina at Chapel Hill

Chapel Hill, North Carolina, 27514, United States
Optimus Medical Group

San Francisco, California, 94102, United States
Orlando Immunology Center

Orlando, Florida, 32803, United States
Prisma Health - Clinical Research Unit

Columbia, South Carolina, 29203, United States
Regional Center for Infectious Disease Research

Greensboro, North Carolina, 27401, United States
Rosedale Health and Wellness

Huntersville, North Carolina, 28078, United States
Ruane Clinical Research Group, Inc.

Los Angeles, California, 90036, United States
Southhampton Healthcare, Inc

St Louis, Missouri, 63139, United States
St Jude Children's Research Hospital

Memphis, Tennessee, 38105, United States
The Brody School of Medicine at East Carolina University

Greenville, North Carolina, 27858, United States
The Crofoot Research Center, INC

Houston, Texas, 77098, United States
Triple O Research Institute, P.A.

West Palm Beach, Florida, 33407, United States
UC San Diego (UCSD) AntiViral Research Center (AVRC)

San Diego, California, 92103, United States
University of Colorado Clinical and Translational Research Center

Aurora, Colorado, 80045, United States
Yale University; School of Medicine; AIDS Program

New Haven, Connecticut, 06510, United States

Conditions

Explore the condition pages connected to this study.

HIV-1 INFECTION