HIV drug switch may protect hearts: small study hints at benefit

NCT ID NCT04820933

First seen Nov 01, 2025 · Last updated May 15, 2026 · Updated 35 times

Summary

This early-phase study tested whether switching HIV medications to doravirine (with emtricitabine/tenofovir alafenamide) could improve cholesterol and reduce early signs of heart disease in 26 people with well-controlled HIV. Participants had stable HIV and high cholesterol. The study measured how the change affected HDL function and other markers of artery health. Results may guide safer long-term HIV treatment.

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Contacts and locations

Locations

  • University of Texas Southwestern

    Dallas, Texas, 75219, United States

  • University of Texas Southwestern Medical Center

    Dallas, Texas, 75219, United States

Conditions

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