Could antibody infusions replace daily HIV pills?
NCT ID NCT03526848
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase study tested whether two lab-made antibodies (3BNC117 and 10-1074) could help people with HIV control the virus after stopping their daily antiretroviral therapy (ART). Twenty-six participants on stable ART received seven infusions of the antibodies, then paused their regular HIV medications. Researchers monitored how long it took for the virus to come back and checked for side effects. The goal was to see if these antibodies could keep the virus in check without daily pills.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- 3BNC117 and 10-1074 (monoclonal antibodies)
- What this could lead to
- If successful, this could point toward a way for people with HIV to control the virus without needing daily antiretroviral therapy.
- What could go wrong
- This is a very early, small phase 1 trial with only 26 participants. The antibodies may not prevent viral rebound, and the effects may not last. There is also a risk of infusion reactions or other side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Ragon Institute of MGH, MIT, and Harvard
Boston, Massachusetts, 02114, United States
-
The Rockefeller University
New York, New York, 10065, United States
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