New radiation combo aims to boost transplant success in tough leukemias

NCT ID NCT03494569

First seen Nov 10, 2025 · Last updated May 14, 2026 · Updated 23 times

Summary

This early-stage study tests a new way to prepare the body for a donor stem cell transplant in people with high-risk leukemia or myelodysplastic syndrome (MDS). It combines targeted radiation (TMLI) with two chemotherapy drugs to kill cancer cells and make room for healthy donor cells. The main goal is to find the safest dose of radiation and check for side effects. The study is currently on hold.

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Contacts and locations

Locations

  • City of Hope Medical Center

    Duarte, California, 91010, United States

Conditions

Explore the condition pages connected to this study.