New triple therapy shows promise for rare, Hard-to-Treat biliary cancers

NCT ID NCT06178445

First seen Apr 17, 2026 · Last updated Apr 28, 2026 · Updated 2 times

Summary

This study tests a combination of chemotherapy (gemcitabine/cisplatin) plus two targeted drugs (trastuzumab and pembrolizumab) as a first treatment for people with HER2-positive bile duct or gallbladder cancer that cannot be removed by surgery. The goal is to see if this triple therapy can shrink tumors and improve outcomes. The trial includes 24 participants and is currently active but not recruiting.

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Contacts and locations

Locations

  • Charité Universitätsmedizin

    Berlin, Germany

  • Hämatologisch-Onkologische Praxis Eppendorf (HOPE)

    Hamburg, Germany

  • Krankenhaus Nordwest (KHNW)

    Frankfurt, Germany

  • LMU München

    München, Germany

  • Medizinische Hochschule Hannover

    Hanover, Germany

  • Universitätsklinikum Augsburg

    Augsburg, Germany

  • Universitätsklinikum Freiburg

    Freiburg im Breisgau, Germany

  • Universitätsklinikum Göttingen

    Göttingen, Germany

Conditions

Explore the condition pages connected to this study.