Heart valve showdown: which mini valve works best?

NCT ID NCT04722250

Ongoing Disease control Sponsor: Medtronic Cardiovascular Source: ClinicalTrials.gov ↗

Summary

This trial is comparing two different types of replacement heart valves for people with a severely narrowed aortic valve and a small aortic root. Over 1,100 participants were randomly assigned to receive either a self-expanding valve or a balloon-expandable valve. The main goal is to see which valve is safer and performs better over five years, especially during physical activity for some participants.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

AOU Integrata Verona

Verona, Italy
Advocate Christ Medical Center

Oak Lawn, Illinois, 60453, United States
Allegheny General Hospital

Pittsburgh, Pennsylvania, 15212, United States
Ascension St. John Hospital

Detroit, Michigan, 48236, United States
AscensionVia Christi St. Francis Hospital

Wichita, Kansas, 67226, United States
Azienda Ospedaliero-Universitaria Pisana - Stabilimento di Cisanello

Pisa, Italy
Baylor Jack and Jane Hamilton Heart and Vascular Hospital

Dallas, Texas, 75226, United States
Baylor Saint Luke's Hospital

Houston, Texas, 77030, United States
Buffalo General Medical Center

Buffalo, New York, 14203, United States
CHU Bordeaux

Pessac, France
Catharina Ziekenhuis

Eindhoven, Netherlands
Cedars Sinai Medical Center

Los Angeles, California, 90048, United States
Centre Hospitalier Universitaire de Clermont-Ferrand

Clermont-Ferrand, France
Centro Hospitalar de Lisboa Ocidental, E.P.E. Hospital de Santa Cruz

Carnaxide, Portugal
Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States
Clinique Pasteur

Toulouse, France
Deutsches Herzzentrum Berlin

Berlin, Germany
Deutsches Herzzentrum Munchen

München, Germany
Emory Structural Heart Clinic and Emory University Midtown

Atlanta, Georgia, 30308, United States
HagaZiekenhuis - Locatie Leyweg

The Hague, Netherlands
HealthPark Medical Center

Fort Myers, Florida, 33908, United States
Helios Health Institute GmbH

Leipzig, Germany
Helsinki University Hospital

Helsinki, Finland
Hers-und Diabeteszentrum NRW - Ruhr -Universitati Bochum

Bad Oeynhausen, Germany
Hillcrest Medical Center

Tulsa, Oklahoma, 74104, United States
Hospital Vall d'Hebron

Barcelona, Spain
Hospital of the University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States
Houston Methodist Hospital

Houston, Texas, 77030, United States
Inova Fairfax Hospital

Falls Church, Virginia, 22042, United States
Inselspital - Universitätsspital Bern

Bern, Switzerland
Intermountain Medical Center

Murray, Utah, 84107, United States
J.W. Ruby Memorial Hospital/West Virginia University

Morgantown, West Virginia, 26506, United States
Kath. St.-Johannes-Gesellschaft Dortmund gGmbH - St. Johannes-Hospital Dortmund

Dortmund, Germany
Lankenau Medical Center

Wynnewood, Pennsylvania, 19096, United States
Los Robles Hospital and Medical Center

Thousand Oaks, California, 91360, United States
Maastricht Universitair Medisch Centrum (MUMC)

Maastricht, Netherlands
Mayo Clinic

Rochester, Minnesota, 55905, United States
Mission Hospital

Asheville, North Carolina, 28801, United States
Missouri Baptist Medical Center

St Louis, Missouri, 63131, United States
Montreal Heart Institute

Montreal, Quebec, H1T 1C8, Canada
Morristown Medical Center

Morristown, New Jersey, 07960, United States
Morton Plant Hospital

Clearwater, Florida, 33756, United States
Mount Sinai Medical Center

Miami Beach, Florida, 33140, United States
NYU Langone Medical Center

New York, New York, 10016, United States
NorthShore Health Systems

Evanston, Illinois, 60201, United States
Penn Presbyterian Medical Center

Philadelphia, Pennsylvania, 19104, United States
Piedmont Atlanta Hospital

Atlanta, Georgia, 30309, United States
Policlinico Sant' Orsala - Malpighi

Bologna, Italy
Providence Health-St. Paul's Hospital

Vancouver, British Columbia, V6Z 1Y6, Canada
Rigshospitalet

Copenhagen, Denmark
Royal Infirmary of Edinburgh

Edinburgh, United Kingdom
Saint George Regional Hospital

St. George, Utah, 84770, United States
Saint Vincent Heart Center of Indiana

Carmel, Indiana, 46290, United States
Scripps Memorial Hospital

La Jolla, California, 92037, United States
Sentara Norfolk General Hospital

Norfolk, Virginia, 23507, United States
Seton Heart Institute

Austin, Texas, 78705, United States
Sheba Medical Center

Ramat Gan, Israel
Spectrum Health

Grand Rapids, Michigan, 49503, United States
St. Cloud Hospital

Saint Cloud, Minnesota, 56303, United States
St. Michaels Hospital/Unity Health Toronto

Toronto, Ontario, Canada
St. Thomas West Hospital

Nashville, Tennessee, 37205, United States
Sutter Health

San Francisco, California, 94109, United States
Tel Aviv Sourasky Medical Center

Tel Aviv, Israel
Texas Health Presbyterian Hospital/Dallas

Dallas, Texas, 76231, United States
The Heart Hospital Baylor Plano

Plano, Texas, 75093, United States
The Icahn School of Medicine at Mount Sinai

New York, New York, 10029, United States
The Leeds Teaching Hospitals NHS Trust - Leeds General Infirmary

Leeds, United Kingdom
The University of Texas Health Science Center at Houston

Houston, Texas, 77030, United States
Toronto General Hospital

Toronto, Ontario, M5G 2C4, Canada
TriHealth / Bethesda North Hospital

Cincinnati, Ohio, 45220, United States
TriStar Centennial Medical Center

Nashville, Tennessee, 37203, United States
Tufts Medical Center

Boston, Massachusetts, 02111, United States
UNC Memorial Hospital

Chapel Hill, North Carolina, 27599, United States
UPMC Pinnacle Harrisburg

Harrisburg, Pennsylvania, 17110, United States
UPMC Presbyterian

Pittsburgh, Pennsylvania, 15213, United States
University Hospitals Cleveland Medical Center

Cleveland, Ohio, 44106, United States
University of Colorado

Aurora, Colorado, 80045, United States
University of Florida

Gainesville, Florida, 32608, United States
University of Iowa Hospitals and Clinics

Iowa City, Iowa, 52242, United States
University of Kansas Medical Center

Kansas City, Kansas, 66160, United States
University of Michigan

Ann Arbor, Michigan, 48109, United States
University of Texas Health Sciences Center at Houston - Center for Advanced Heart Failure

Houston, Texas, 77030, United States
University of Virginia

Charlottesville, Virginia, 22903, United States
Universitätsklinikum Düsseldorf

Düsseldorf, Germany
Universitätsklinikum Schleswig-Holstein - Campus Kiel

Kiel, Germany
Universitätsklinikum Schleswig-Holstein - Campus Lübeck

Lübeck, Germany
Victoria Heart Institute Foundation/Royal Jubilee Hospital

Victoria, British Columbia, Canada
WHC Washington MedStar

Washington D.C., District of Columbia, 20010, United States
Weill Cornell Medical Center

New York, New York, 10065, United States
Wellstar Kennestone Hospital

Marietta, Georgia, 30060, United States
Yale New Haven Hospital

New Haven, Connecticut, 06510, United States
York Hospital

York, Pennsylvania, 17403, United States

Conditions

Explore the condition pages connected to this study.

AORTIC VALVE REPLACEMENT AORTIC VALVE STENOSIS SYMPTOMATIC AORTIC STENOSIS