New monthly shot aims to put the brakes on a hardening heart valve

NCT ID NCT05646381

Recruiting now Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

Summary

This study is testing whether a monthly injection called pelacarsen can slow down the worsening of a narrowed and hardened heart valve (aortic stenosis). It will involve about 502 adults aged 50-80 who have mild-to-moderate valve disease and a specific high blood marker. Participants will receive either the active drug or a placebo (dummy injection) for 3 years to see which one better slows the valve's progression.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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AA Medical Research Center
RECRUITING

Flint, Michigan, 48504, United States

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Advanced Research for Health Improvement LLC
ACTIVE_NOT_RECRUITING

Naples, Florida, 34102, United States
Brigham and Womens Hosp Harvard Med School
RECRUITING

Boston, Massachusetts, 02115, United States
Brigham and Womens Hosp Harvard Med School
RECRUITING

Boston, Massachusetts, 02115, United States

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Capital Cardiology Associates
RECRUITING

Albany, New York, 12211, United States

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Cardiovascular Res Found
RECRUITING

Beverly Hills, California, 90210, United States

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Carient Heart and Vascular
RECRUITING

Manassas, Virginia, 20109, United States

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Excel Medical Clinical Trials LLC
WITHDRAWN

Boca Raton, Florida, 33434, United States
Flourish Clinical Resrch Covin
RECRUITING

Covina, California, 91723, United States

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Flourish Res Acq LLC North Miami
RECRUITING

Miami, Florida, 33138, United States

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Heart Center Research Llc
RECRUITING

Huntsville, Alabama, 35801, United States

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Henry Ford Hospital
RECRUITING

Detroit, Michigan, 48202, United States
Henry Ford Hospital
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Detroit, Michigan, 48202, United States

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Icahn School of Med at Mt Sinai
RECRUITING

New York, New York, 10029, United States

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Inpatient Research Clinical LLC
RECRUITING

Miami Lakes, Florida, 33014, United States

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Lindner Ctr At The Christ Hosp
RECRUITING

Cincinnati, Ohio, 45219, United States

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Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States

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Midwest Heart and Vascular Spec
RECRUITING

Overland Park, Kansas, 66211, United States

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Minneapolis Heart Institute
WITHDRAWN

Minneapolis, Minnesota, 55407, United States
National Heart Institute
RECRUITING

Beverly Hills, California, 90211, United States

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New York Presbyterian Hospital
ACTIVE_NOT_RECRUITING

New York, New York, 10021, United States
Nova Clinical Research LLC
RECRUITING

Bradenton, Florida, 34209, United States

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Novartis Investigative Site
RECRUITING

Innsbruck, Tyrol, 6020, Austria
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WITHDRAWN

Linz, 4021, Austria
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Vienna, 1190, Austria
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Vienna, A 1090, Austria
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Genk, Limburg, 3600, Belgium
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Yvoir, Namur, 5530, Belgium
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Aalst, Oost Vlaanderen, 9300, Belgium
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Kortrijk, West-Vlaanderen, 8500, Belgium
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Roeselare, West-Vlaanderen, 8800, Belgium
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Cambridge, Ontario, N1R 6V6, Canada
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North York, Ontario, M6B 3H7, Canada
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Ottawa, Ontario, K1Y 4W7, Canada
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Montreal, Quebec, H1T 1C8, Canada
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Montreal, Quebec, H3T 1E2, Canada
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Montreal, Quebec, H4A 3J1, Canada
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Québec, Quebec, G1V 4G5, Canada
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Hradec Králové, 500 02, Czechia
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Jaroměř, 551 01, Czechia
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Prague, 128 08, Czechia
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Prague, 14021, Czechia
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Prague, 150 06, Czechia
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Esbjerg, 6700, Denmark
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Hvidovre, 2650, Denmark
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Roskilde, 4000, Denmark
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Viborg, 8800, Denmark
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Paris, 75012, France
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Paris, 75013, France
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Paris, 75015, France
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Pessac, 33604, France
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Poitiers, 86021, France
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Rennes, 35033, France
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Frankfurt am Main, Hesse, 60594, Germany
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Kaiserslautern, Rhineland-Palatinate, 67655, Germany
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Dresden, Saxony, 01099, Germany
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Leipzig, Saxony, 04289, Germany
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Ahaus, 48683, Germany
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Berlin, 13353, Germany
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Bonn, 53105, Germany
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Essen, 45147, Germany
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Hamburg, 20246, Germany
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Hamburg, 22763, Germany
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WITHDRAWN

Lüneburg, 21339, Germany
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Mannheim, 68165, Germany
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München, 80636, Germany
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Münster, 48149, Germany
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Oldenburg, 26133, Germany
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Beersheba, 8457108, Israel
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Haifa, 3104802, Israel
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Haifa, 3109601, Israel
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Jerusalem, 9103102, Israel
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Jerusalem, 9112001, Israel
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Nahariya, 2210001, Israel
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Petah Tikva, 4941492, Israel
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Ramat Gan, 5265601, Israel
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Tel Aviv, 6423906, Israel
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Ancona, AN, 60126, Italy
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Bergamo, BG, 24127, Italy
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Bologna, BO, 40138, Italy
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Brescia, BS, 25123, Italy
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Caserta, CE, 81100, Italy
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Cona, FE, 44124, Italy
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Pozzilli, IS, 86077, Italy
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Milan, MI, 20138, Italy
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Milan, MI, 20157, Italy
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Milan, MI, 20162, Italy
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Padua, PD, 35128, Italy
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Pordenone, PN, 33170, Italy
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Amsterdam, North Holland, 1090 HM, Netherlands
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Amsterdam, North Holland, 1105 AZ, Netherlands
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Rotterdam, South Holland, 3015 GD, Netherlands
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Rotterdam, South Holland, 3079 DZ, Netherlands
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Nieuwegein, Utrecht, 3435 CM, Netherlands
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Alcabideche, 2755-009, Portugal
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Braga, 4710243, Portugal
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Coimbra, 3004-561, Portugal
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Vila Nova de Gaia, 4434 502, Portugal
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Cáceres, Extremadura, 10003, Spain
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Córdoba, 14004, Spain
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Madrid, 28034, Spain
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WITHDRAWN

Madrid, 28040, Spain
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Madrid, 28041, Spain
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Madrid, 28046, Spain
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Salamanca, 37007, Spain
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Valencia, 46010, Spain
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Basel, 4031, Switzerland
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Geneva, 1211, Switzerland
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Lausanne, 1011, Switzerland
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Lugano, 6900, Switzerland
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Zurich, 8091, Switzerland
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Portadown, Nothern Ireland, BT63 5QQ, United Kingdom
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Edinburgh, ED16 4SA, United Kingdom
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Leicester, LE3 9QP, United Kingdom
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Liverpool, L14 3PE, United Kingdom
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London, EC1A 7BE, United Kingdom
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London, SE1 7EH, United Kingdom
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Londonderry, BT47 6SB, United Kingdom
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Manchester, M23 9LT, United Kingdom
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Middlesbrough, TS4 3BW, United Kingdom
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RECRUITING

Tyne and Wear, NE29 8NH, United Kingdom
Ohio State University
ACTIVE_NOT_RECRUITING

Columbus, Ohio, 43210, United States
Orion Medical
RECRUITING

Houston, Texas, 77034, United States

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Overlook Medical Center
RECRUITING

Summit, New Jersey, 07901, United States

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Perelman School of Medicine
RECRUITING

Philadelphia, Pennsylvania, 19104, United States

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Stanford University Medical Center
RECRUITING

Palo Alto, California, 94304, United States

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Strong Memorial Hospital
RECRUITING

Rochester, New York, 14642, United States

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Tufts Medical Center
RECRUITING

Boston, Massachusetts, 02111, United States

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UC San Francisco Medical Center
RECRUITING

San Francisco, California, 94143, United States

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University Of California San Diego
RECRUITING

San Diego, California, 92103-8415, United States

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University Of Minnesota
RECRUITING

Minneapolis, Minnesota, 55455, United States

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Valley Clinical Trials
RECRUITING

Northridge, California, 91325, United States

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Virginia Heart
RECRUITING

Falls Church, Virginia, 22042, United States

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Wake Forest University Baptist Medical Center
RECRUITING

Winston-Salem, North Carolina, 27157, United States

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William Beaumont Hospital
RECRUITING

Royal Oak, Michigan, 48073-4192, United States

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Conditions

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AORTIC STENOSIS