Heart failure drug entresto: scientists uncover how it works
NCT ID NCT04649229
First seen Dec 10, 2025 · Last updated Jun 19, 2026 · Updated 22 times
Summary
This completed Phase 4 study at Yale University looked at how the heart failure drug Entresto (LCZ696) lowers blood pressure and affects sodium excretion. 46 stable heart failure patients with reduced ejection fraction participated. The goal was to understand the body's response to the drug, not to test a new treatment.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Yale New Haven Hospital
New Haven, Connecticut, 06520, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Entresto (LCZ696)
What this could lead to
If successful, this could help doctors understand how Entresto lowers blood pressure in heart failure patients, potentially leading to better use of the drug.
What could go wrong
This is a small, completed study focused on understanding mechanisms, not testing a new treatment. Results may not change current practice or apply to all patients.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.